Journal of Pineal Research,
Journal Year:
2020,
Volume and Issue:
69(3)
Published: July 13, 2020
Abstract
Almost
all
living
organisms
have
evolved
autoregulatory
transcriptional‐translational
feedback
loops
that
produce
oscillations
with
a
period
of
approximately
24‐h.
These
endogenous
time
keeping
mechanisms
are
called
circadian
clocks.
The
main
function
these
clocks
is
to
drive
overt
rhythms
in
the
physiology
ensure
physiological
functions
synchrony
external
environment.
Disruption
caused
by
genetic
or
environmental
factors
has
long‐term
consequences
for
metabolic
health.
Of
relevance,
host
rhythmicity
and
lipid
metabolism
increasingly
recognized
cross‐regulate
clock‐lipid
interplay
may
involve
development
obesity.
Multiple
systemic
molecular
mechanisms,
such
as
hormones
(ie,
melatonin,
leptin,
glucocorticoid),
gut
microbiome,
energy
metabolism,
link
clock
predictably,
deregulation
can
increase
risk
obesity,
which
turn
exacerbate
disorganization.
Feeding
dietary
nutrients
two
key
Zeitgebers
affecting
rhythm‐lipid
interplay,
influencing
obesity
highlighted
this
review.
Together,
characterization
machinery
aimed
at
producing
healthy
lifestyle
improve
care.
Animal nutrition,
Journal Year:
2020,
Volume and Issue:
6(2), P. 115 - 123
Published: Jan. 23, 2020
Tea
trees
have
a
long
history
of
cultivation
and
utilization.
People
in
many
countries
the
habit
drinking
tea
choosing
green
tea,
oolong
or
black
according
to
different
regions
personal
tastes.
polyphenols
are
general
term
for
polyphenol
compounds
has
been
shown
good
effects
on
antioxidant,
anti-inflammatory,
cancer
prevention
regulation
lipid
metabolism.
widely
used
as
antioxidants
disease
treatment
animal
husbandry,
but
their
specific
mechanism
action
needs
be
further
clarified
revealed.
This
review
focuses
definition,
classification,
antioxidant
activity
signaling
pathways
polyphenols.
paper
also
aims
examine
application
human
health,
providing
scientific
basis
this
addition
proposing
future
directions
development
resource.
Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(9), P. 1211 - 1211
Published: Aug. 20, 2020
There
is
a
growing
consensus
that
the
antioxidant
and
anti-inflammatory
properties
of
melatonin
are
great
importance
in
preserving
body
functions
homeostasis,
with
impact
peripartum
period
adult
life.
Melatonin
promotes
adaptation
through
allostasis
stands
out
as
an
endogenous,
dietary,
therapeutic
molecule
important
health
benefits.
The
effects
intertwined
exerted
throughout
pregnancy
later
during
development
aging.
supplementation
can
reduce
ischemia-induced
oxidative
damage
fetal
brain,
increase
offspring
survival
inflammatory
states,
blood
pressure
offspring.
In
adulthood,
disturbances
production
negatively
progression
cardiovascular
risk
factors
promote
neurodegenerative
diseases.
most
studied
linked
to
hypertension
myocardial
ischemia/reperfusion
injury,
while
promising
ones
regaining
control
metabolic
syndrome
components.
addition,
there
might
be
emerging
role
for
adjuvant
treating
coronavirus
disease
2019
(COVID
19).
present
review
summarizes
comments
on
data
regarding
roles
by
homeostasis
stress
inflammation
related
pathologies.
Microbiome,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: July 20, 2021
Feelings
of
hunger
and
satiety
are
the
key
determinants
for
maintaining
life
humans
animals.
Disturbed
appetite
control
may
disrupt
metabolic
health
host
cause
various
disorders.
A
variety
factors
have
been
implicated
in
control,
including
gut
microbiota,
which
develop
intricate
interactions
to
manipulate
requirements
hedonic
feelings.
Gut
microbial
metabolites
components
act
as
appetite-related
signaling
molecules
regulate
hormone
secretion
immune
system,
or
directly
on
hypothalamic
neurons.
Herein,
we
summarize
effects
microbiota
consider
potential
molecular
mechanisms.
Furthermore,
propose
that
manipulation
represents
a
clinical
therapeutic
lessening
development
consequence
Video
abstract.
Frontiers in Pharmacology,
Journal Year:
2020,
Volume and Issue:
11
Published: March 13, 2020
Atherosclerosis
and
its
associated
cardiovascular
diseases
(CVDs)
are
serious
threats
to
human
health
have
been
reported
be
with
the
gut
microbiota.
Recently,
role
of
berberine
(BBR)
in
atherosclerosis
microbiota
has
begun
appreciated.
The
purposes
this
study
were
observe
effects
high
or
low
doses
BBR
on
modulation,
explore
their
correlation
ApoE
AJP Endocrinology and Metabolism,
Journal Year:
2022,
Volume and Issue:
324(1), P. E24 - E41
Published: Nov. 16, 2022
The
prevalence
of
obesity
has
increased
dramatically
during
the
past
decades,
which
been
a
major
health
problem.
Since
1975,
number
people
with
worldwide
nearly
tripled.
An
increasing
studies
find
as
driver
chronic
kidney
disease
(CKD)
progression,
and
mechanisms
are
complex
include
hemodynamic
changes,
inflammation,
oxidative
stress,
activation
renin-angiotensin-aldosterone
system
(RAAS).
Obesity-related
is
characterized
by
glomerulomegaly,
often
accompanied
localized
segmental
glomerulosclerosis
lesions.
In
these
patients,
early
symptoms
atypical,
microproteinuria
being
main
clinical
manifestation
nephrotic
syndrome
rare.
Weight
loss
RAAS
blockers
have
protective
effect
on
obesity-related
CKD,
but
even
so,
significant
proportion
patients
eventually
progress
to
end-stage
renal
despite
treatment.
Thus,
it
critical
comprehend
underlying
CKD
create
new
tactics
for
slowing
or
stopping
progression.
this
review,
we
summarize
current
knowledge
disease,
its
pathological
future
perspectives
Frontiers in Microbiology,
Journal Year:
2020,
Volume and Issue:
11
Published: March 26, 2020
The
global
prevalence
of
obesity
is
rising
year
by
year,
which
has
become
a
public
health
problem
worldwide.
In
recent
years,
animal
studies
and
clinical
have
shown
that
some
lactic
acid
bacteria
possess
an
anti-obesity
effect.
our
previous
study,
mixed
lactobacilli
(
Microbial Biotechnology,
Journal Year:
2020,
Volume and Issue:
13(3), P. 637 - 656
Published: Jan. 26, 2020
The
intestine
is
colonized
by
a
considerable
community
of
microorganisms
that
cohabits
within
the
host
and
plays
critical
role
in
maintaining
homeostasis.
Recently,
accumulating
evidence
has
revealed
gut
microbial
ecology
pivotal
occurrence
development
cardiovascular
disease
(CVD).
Moreover,
effects
imbalances
microbe-host
interactions
on
homeostasis
can
lead
to
progression
CVD.
Alterations
composition
flora
disruptions
metabolism
are
implicated
pathogenesis
Furthermore,
microbiota
functions
like
an
endocrine
organ
produces
bioactive
metabolites,
including
trimethylamine/trimethylamine
N-oxide,
short-chain
fatty
acids
bile
acids,
which
also
involved
health
via
numerous
pathways.
Thus,
its
metabolic
pathways
have
attracted
growing
attention
as
therapeutic
target
for
CVD
treatment.
fundamental
purpose
this
review
was
summarize
recent
studies
illustrated
complex
between
microbiota,
their
metabolites
common
CVD,
well
dysbiosis
risk
factors.
we
systematically
discuss
normal
physiology
potential
strategies
targeting
prevent
treat
