Effectiveness of virtual simulation and jaw model for undergraduate periodontal teaching

BMC Medical Education, Journal Year: 2021, Volume and Issue: 21(1)

Published: Dec. 1, 2021

Language: Английский

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Multiple Brain Abscesses of Odontogenic Origin. May Oral Microbiota Affect Their Development? A Review of the Current Literature

Applied Sciences, Journal Year: 2021, Volume and Issue: 11(8), P. 3316 - 3316

Published: April 7, 2021

In the last few years, role of oral microbiota in setting diseases such as caries, periodontal disease, cancer and systemic infections, including rheumatoid arthritis, cardiovascular disease brain abscess (BA), has attracted attention physicians researchers. Approximately 5–7% all BAs have an odontogenic origin, representing important pathological condition with a high morbidity mortality. A systematic search two databases (Pubmed Ovid EMBASE) was performed for studies published up to 5 January 2021, reporting multiple attributed origin. According PRISMA guidelines, we included total 16 papers due infections. The aim this review is investigate treatment modality clinical outcome patients well identify most common pathogens involved status their role, microbiota, onset multidisciplinary approach essential management BAs. Further are required understand better development

Language: Английский

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Circulating MicroRNA Expression, Vitamin D, and Hypercortisolism as Predictors of Osteoporosis in Elderly Postmenopausal Women

Disease Markers, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 12

Published: Dec. 13, 2021

Background. MicroRNAs (miRNA) identified as critical molecular regulators for bone development, function, and modeling/remodeling process could be predictable osteoporotic fractures in postmenopausal elderly women. Aim. The potential diagnostic role of circulating miRNAs, miR-148a miR-122-5p, the pathogenesis osteoporosis its association with markers, hypercortisolism, vitamin D deficiency were explored women osteoporosis. Methods. A total 120 aged 50–80 years old recruited this study, which only 100 eligible amenorrhea at least 12 consecutive months or surgical menopause participated study. Based upon mineral density (BMD) measurements, participants classified according into two groups: normal ( n=45 ; T score ≥-1.0) n=55 T score: ≤-2.5). Circulating estimated by real-time RT-PCR analysis. In addition, colorimetrically ELISA immune assay estimated. miR-148a, cortisol, diagnosis was predicted using analysis respective area under receiver operating characteristic curve (AUC-ROC). Results. expressed level significantly increased miR-122-5p decreased serum patients compared to healthy controls. a significant increase levels s-BAP, CTx decrease T-BMD, OC, s-Ca also identified. All parameters correlated fracture risk parameters; BMD, T lumbar spine (L2-L4). Thus, data showed AUC cut off values (miR-148a; 0.876, miR-122-5p; 0.761) best evaluated clinical that 0.748 cortisol 0.635 values, respectively, reported prediction diagnosis. Conclusion. miRNAs changes both status are associated loss circulation alone combination might considered biomarkers women; however, more studies recommended.

Language: Английский

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Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of patients with chronic periodontitis: a randomized controlled clinical trial

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 19, 2023

To evaluate the effect of curcumin gel combined with scaling and root planing (SRP) on salivary procalcitonin in periodontitis treatment.

Language: Английский

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A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis

Journal of Inflammation Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 5337 - 5347

Published: Oct. 1, 2021

Purpose: Clinically, it is challenging to manage diabetic patients with periodontitis. Biochemically, both involve a wide range of inflammatory/collagenolytic conditions which exacerbate each other in "bi-directional manner." However, standard treatments for this type periodontitis rely on reducing the bacterial burden and less controlling hyper-inflammation/excessive-collagenolysis. Thus, there crucial need new therapeutic strategies modulate excessive host response promote enhanced resolution inflammation. The aim current study evaluate impact novel chemically-modified curcumin 2.24 (CMC2.24) inflammatory rats. Methods: Type I diabetes was induced by streptozotocin injection; periodontal breakdown then results as complication uncontrolled hyperglycemia. Non-diabetic rats served controls. CMC2.24, or vehicle-alone, administered oral gavage daily 3 weeks diabetics. Micro-CT used analyze morphometric changes quantify bone loss. MMPs were analyzed gelatin zymography. Cell function examined cell migration assay, cytokines resolvins measured ELISA. Results: In severe disease model, administration pleiotropic CMC2.24 found normalize accumulation impaired chemotactic activity macrophages peritoneal exudates, significantly decrease MMP-9 pro-inflammatory near normal levels, markedly increase resolvin D 1 (RvD ) levels thioglycolate-elicited exudates (tPE). Similar effects RvD observed non-elicited resident washes (rPW). Regarding clinical relevance, inhibited loss alveolar height, volume mineral density (ie, diabetes-induced osteoporosis). Conclusion: conclusion, treating hyperglycemic (a tri-ketonic phenylaminocarbonyl curcumin) promotes local systemic inflammation, reduces loss, addition suppressing collagenolytic cytokines, suggesting strategy complicated chronic diseases. Keywords: hyperglycemia, periodontitis, matrix metalloproteinases, resolvins, host-modulatory therapy

Language: Английский

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