Research Society and Development,
Journal Year:
2022,
Volume and Issue:
11(1), P. e17711124185 - e17711124185
Published: Jan. 4, 2022
Objective:
This
study
evaluated
clinical,
glucose,
and
immunological
parameters
in
patients
with
type
2
diabetes
mellitus
(DM)
compared
to
those
without
systemic
alterations
(NDM),
both
generalized
chronic
periodontitis.
Methodology:
Twenty-one
were
selected
indications
of
tooth
loss.
Surgeries
performed
using
the
Widman
flap
modified
obtain
a
gingival
collar
at
1
mm
from
margin.
Before
surgical
procedure,
following
clinical
evaluated:
pocket
probing
depth
(PPD),
recession
(GR),
attachment
level
(CAL),
bleeding
on
(BOP).
Fasting
glucose
levels
(FGL)
glycosylated
hemoglobin
Hba1c
(HbA1c)
also
assessed.
During
surgery,
tissue
samples
collected
frozen
for
later
laboratorial
analysis.
The
processed
mRNA,
cDNA
determine
gene
expression
immune
IL-1-β,
IL-6,
TNF-α,
IL-10
NF-kB
by
real-time
polymerase
chain
reaction
(RT-PCR).
Data
analyzed
statistically
considering
p<0.05.
Results:
BOP,
FGL,
HbA1c
higher
DM
group.
RNAm
IL-1β,
group
(p<0.05).
Conclusion:
presence
hyperglycemic
status
increase
pro-inflammatory
factors
severity
periodontal
disease.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 16, 2023
Diabetes
mellitus
is
a
main
risk
factor
for
periodontitis,
but
until
now,
the
underlying
molecular
mechanisms
remain
unclear.
can
increase
pathogenicity
of
periodontal
microbiota
and
inflammatory/host
immune
response
periodontium.
Hyperglycemia
induces
reactive
oxygen
species
(ROS)
production
enhances
oxidative
stress
(OS),
exacerbating
tissue
destruction.
Furthermore,
alveolar
bone
resorption
damage
epigenetic
changes
in
induced
by
diabetes
may
also
contribute
to
periodontitis.
We
will
review
latest
clinical
data
on
evidence
promoting
susceptibility
periodontitis
from
epidemiological,
mechanistic,
potential
therapeutic
targets
discuss
possible
mechanistic
targets,
focusing
particular
novel
OS.
Understanding
intertwined
pathogenesis
explain
cross-interference
between
endocrine
metabolic
inflammatory
diseases
better,
provide
theoretical
basis
new
systemic
holistic
treatment,
promote
interprofessional
collaboration
physicians
dentists.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 23, 2022
Diabetes
mellitus
is
a
common
systematic
chronic
disease
amongst
dental
patients.
The
elevated
glucose
microenvironment
can
prolong
the
healing
of
tooth
extraction
sockets.
Therefore,
promotion
up
sockets
great
clinical
importance
to
patients
with
diabetes
mellitus.
current
evidence
indicates
mechanism
recovery
period
in
hyperglycaemia
conditions
from
physiological,
inflammation,
immune,
endocrine
and
neural
aspects.
New
advancements
have
been
made
varied
curative
approaches
drugs
management
wound
diabetes.
However,
most
interventions
are
still
stage
animal
experiments,
whether
it
be
put
into
application
needs
further
explorations.
Specifically,
our
work
showed
topical
administration
plasma-rich
growth
factor,
advanced
platelet-rich
fibrin,
leukocyte-
fibrin
hyaluronic
acid
as
well
maxillary
immediate
complete
denture
regarded
promising
approach
for
diabetic
requiring
extractions.
Overall,
recent
studies
present
blueprint
new
advances
novel
effective
this
worldwide
health
ailment
healing.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 18, 2023
Osteoporosis
(OP)
is
one
of
the
most
common
metabolic
skeletal
disorders
and
commonly
seen
in
elderly
population
postmenopausal
women.
It
mainly
associated
with
progressive
loss
bone
mineral
density,
persistent
deterioration
microarchitecture,
increased
fracture
risk.
To
date,
drug
therapy
primary
method
used
to
prevent
treat
osteoporosis.
However,
long-term
inevitably
leads
resistance
specific
side
effects.
Therefore,
researchers
are
constantly
searching
for
new
monomer
compounds
from
natural
plants.
As
a
candidate
treatment
osteoporosis,
curcumin
(CUR)
phenolic
compound
various
pharmacological
biological
activities,
including
antioxidant,
anti-apoptotic,
anti-inflammatory.
This
has
gained
research
attention
maintaining
health
osteoporosis
models.
We
reviewed
preclinical
clinical
studies
preventing
alleviating
These
results
suggest
that
if
subjected
rigorous
trials,
naturally-derived
could
be
as
complementary
alternative
medicine
by
targeting
osteoporosis-related
mechanistic
pathways.
review
summarizes
mechanisms
action
potential
therapeutic
applications
prevention
mitigation
provides
reference
further
development
curcumin.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Nov. 30, 2021
Osteoporosis
is
a
prevalent
bone
disorder
characterized
by
mass
reduction
and
deterioration
of
microarchitecture
leading
to
fragility
fracture
risk.
In
recent
decades,
knowledge
regarding
the
etiological
mechanisms
emphasizes
that
inflammation,
oxidative
stress
senescence
cells
contribute
development
osteoporosis.
Studies
have
demonstrated
heme
oxygenase
1
(HO-1),
an
inducible
enzyme
catalyzing
degradation,
exhibits
anti-inflammatory,
anti-oxidative
anti-apoptosis
properties.
Emerging
evidence
has
revealed
HO-1
critical
in
maintenance
homeostasis,
making
potential
target
for
osteoporosis
treatment.
this
Review,
we
aim
provide
introduction
current
biology
its
regulation,
focusing
specifically
on
roles
homeostasis
We
also
examine
HO-1-based
pharmacological
therapeutics
issues
faced
during
clinical
translation.
Journal Of Clinical Periodontology,
Journal Year:
2024,
Volume and Issue:
51(6), P. 742 - 753
Published: Jan. 24, 2024
Abstract
Aim
To
investigate
the
specific
role
of
arrestin
beta‐2
(ARRB2)
in
progression
periodontitis
and
underlying
mechanisms.
Materials
Methods
Single‐cell
RNA
sequencing
data
were
used
to
analyse
gene
expression
periodontal
tissues
from
healthy
controls
patients
with
periodontitis.
Real‐time
quantitative
polymerase
chain
reaction,
Western
blotting
immunohistochemical
staining
performed
detect
ARRB2.
Furthermore,
a
ligature‐induced
model
was
created.
Using
radiographic
histological
methods,
luciferase
assay,
ARRB2
mechanisms
explored.
Finally,
therapeutic
effect
melatonin,
an
inhibitor
activating
transcription
factor
6
(ATF6),
on
mice
assessed
both
vivo
vitro
experiments.
Results
up‐regulated
inflammatory
tissue.
In
mouse
model,
Arrb2
knockout
exacerbated
alveolar
bone
loss
(ABL)
extracellular
matrix
(ECM)
degradation.
exerted
negative
regulatory
ATF6
,
essential
targeted
gene.
Melatonin
ameliorated
ABL
imbalance
ECM
remodelling
‐deficient
mice.
Conclusions
mediates
via
inhibition
signalling
pathway,
which
ultimately
exerts
protective
tissues.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 116995 - 116995
Published: June 24, 2024
Osteoporosis
is
a
prevalent
bone
metabolic
disease
that
poses
significant
challenge
to
global
human
health.
Jaw
osteoporosis,
characterized
by
microstructural
damage
of
the
jaw
resulting
from
various
factors,
one
common
manifestations
this
condition.
Recent
studies
have
demonstrated
osteoporosis
has
multifaceted
effects
on
oral
health
and
can
negatively
impact
conditions
such
as
periodontitis,
implantation,
orthodontic
treatment,
wound
healing.
However,
there
are
still
some
limitations
in
conventional
treatment
osteoporosis.
For
instance,
while
bisphosphonates
enhance
quality,
they
may
also
lead
osteonecrosis
jaw,
which
potential
safety
hazard
diagnosis
treatment.
In
recent
years,
considerable
attention
been
focused
improving
pathological
condition
Treatment
strategies
gut
microbial
regulation,
extracellular
vesicles,
molecular
targeted
therapy,
herbal
medicine,
mechanical
stimulation
expected
efficacy
minimize
adverse
reactions.
Therefore,
understanding
these
exploring
novel
treatments
for
provide
new
insights
maintenance
This
article
reviews
describes
associated
with
current
methods.
It
discusses
emerging
perspectives
offering
comprehensive
overview
challenges
future
directions
managing
Biomedical Journal,
Journal Year:
2023,
Volume and Issue:
47(1), P. 100605 - 100605
Published: May 11, 2023
Curcumin
ameliorates
bone
loss
by
inhibiting
osteoclastogenesis.
inhibits
RANKL-promoted
autophagy
in
osteoclast
precursors
(OCPs),
which
mediates
its
anti-osteoclastogenic
effect.
But
the
role
of
RANKL
signaling
curcumin-regulated
OCP
is
unknown.
This
study
aimed
to
explore
relationship
between
curcumin,
signaling,
and
during
We
investigated
curcumin
RANKL-related
molecular
OCPs,
identified
significance
RANK-TRAF6
curcumin-treated
osteoclastogenesis
using
flow
sorting
lentiviral
transduction.
Tg-hRANKL
mice
were
used
observe
vivo
effects
on
RANKL-regulated
loss,
osteoclastogenesis,
autophagy.
The
JNK-BCL2-Beclin1
pathway
with
was
explored
via
rescue
assays
BCL2
phosphorylation
detection.
inhibited
repressed
differentiation
sorted
RANK+
OCPs
but
did
not
affect
those
RANK−
OCPs.
Curcumin-inhibited
recovered
TRAF6
overexpression.
lost
these
under
knockdown.
Furthermore,
prevented
decrease
mass
increase
trabecular
formation
mice.
Additionally,
curcumin-inhibited
reversed
JNK
activator
anisomycin
TAT-Beclin1
overexpressing
Beclin1.
at
Ser70
enhanced
protein
interaction
Beclin1
suppresses
downstream
RANKL,
contributing
Moreover,
plays
an
important
Frontiers in Clinical Diabetes and Healthcare,
Journal Year:
2025,
Volume and Issue:
6
Published: March 3, 2025
Diabetes
mellitus
is
a
much-studied
disorder,
characterized
by
hyperglycemia
and
numerous
oral
medical
complications.
The
latter
includes
(above
all)
decreased
life-span
—
these
are
widely
discussed
in
the
dental
literature.
complications
include
impaired
wound
healing;
increased
severity
of
periodontal
disease
peri-implantitis;
dry
mouth
(xerostomia);
caries.
relationship
between
diabetes
health
bi-directional:
Optimal
management
local
can
profoundly
affect
systemic
metabolic
control
diabetic
patient,
strict
patient’s
reduce
its
impact
on
disease.
only
host
modulation
therapy
(HMT),
approved
U.S.
Food
Drug
Administration
(FDA)
to
treat
disease,
novel
NON-antimicrobial
(low-dose)
formulation
doxycycline
(Periostat
®
;
20
mg
b.i.d).
A
publication
Scientific
Reports
(2017),
which
supported
clinical
rationale
efficacy
safety
low-dose
diabetics,
stated:
“doxycycline
not
ameliorated
insulin
resistance,
fasting
blood
glucose,
levels,
lipid
profiles
circulation
liver,
but
also
improved
islet
morphology
glucose-stimulated
secretion.”
Additional
developments
biphenolic
chemically-modified
curcumins,
as
HMT
for
managing
diseases.
lead
compound,
curcumin
2.24
(CMC2.24),
has
demonstrated
vitro
,
cell
culture,
vivo
using
mouse,
rat,
rabbit,
dog
models
In
conclusion,
host-modulation
compounds
have
shown
significant
promise
adjuncts
traditional
other
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2853 - 2853
Published: March 21, 2025
Periodontitis
is
unanimously
accepted
to
be
the
sixth
complication
of
diabetes
mellitus
(DM),
while
inverse
relationship
causality
still
deciphered.
Among
proposed
mechanisms
gut
dysbiosis,
which
responsible
for
systemic
release
proinflammatory
mediators.
In
this
process,
Gram-negative
bacteria
from
oral
cavity
enter
general
circulation,
leading
emergence
bi-hormonal
beta-pancreatic
cells
that
lack
ability
secrete
insulin.
Additionally,
epigenetic
and
adaptive
in
affected
may
play
a
role
reducing
inflammation.
The
reactive
oxygen
species,
cytokines,
adipokines,
such
as
interleukins,
tumor
necrosis
factor
alpha,
leptin,
prostaglandin
E2,
C-reactive
protein,
or
matrix
metalloproteinases,
determine
changes,
methylation
DNA
nucleotides
changes
activity
histone
acetylases/deacetylases.
management
periodontitis
involves
targeting
inflammation,
its
potential
connection
modulation
observed
other
chronic
conditions
help
explain
preventing
DM
patients.
This
review
focuses
on
key
might
contribute
development,
explores
novel
multi-drug
therapies
could
prevent
these
effects.
