Current status and future trends of the global burden of MASLD

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(8), P. 697 - 707

Published: Feb. 29, 2024

Language: Английский

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Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease

Journal of Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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MASLD/MetALD and mortality in individuals with any cardio-metabolic risk factor: A population-based study with 26.7 years of follow-up

Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: May 13, 2024

Background and Aims: A new term, metabolic dysfunction–associated steatotic liver disease (MASLD), has been proposed by a multi-society expert panel. However, it remains unclear whether hepatic steatosis per se in MASLD contributes to an increased risk of mortality individuals with any cardio-metabolic factor (CMRF), which is also significant for mortality. This study aimed compare all-cause cause-specific between the “MASLD/MetALD” “no (SLD)” groups CMRF. Approach Results: population-based cohort was conducted using 10,750 participants Third National Health Nutrition Examination Survey. All-cause (cardiovascular, cancer, diabetes, liver) risks were compared “MASLD,” “MetALD,” SLD” Cox proportional hazards model complex survey design weights, adjusted confounders. Over 26 years, “MASLD” group did not show significantly (adjusted HR 1.04[95% CI: 0.95–1.14], p = 0.413), cardiovascular (0.88 [0.75–1.04], 0.139), or cancer (1.06[0.84–1.33], 0.635) The MetALD associated (1.41 [1.05–1.89], 0.022), (2.35 [1.33–4.16], 0.004), (15.04 [2.96–76.35], 0.002) no SLD group. trend more pronounced advanced fibrosis assessed Fibrosis-4 (FIB-4). Conclusions: In CMRF, presence (MASLD) alone increase mortality, except cases alcohol consumption (MetALD). Therefore controlling factors reducing people will be crucial steps improve long-term health outcomes.

Language: Английский

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Heavy arch: from inflammatory bowel diseases to metabolic disorders

Gut, Journal Year: 2024, Volume and Issue: 73(8), P. 1376 - 1387

Published: May 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Language: Английский

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Liver and cardiovascular outcomes in lean non-alcoholic fatty liver disease: an updated systematic review and meta-analysis of about 1 million individuals

Hepatology International, Journal Year: 2024, Volume and Issue: 18(5), P. 1396 - 1415

Published: Aug. 8, 2024

Language: Английский

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Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Liver International, Journal Year: 2024, Volume and Issue: 44(7), P. 1513 - 1525

Published: April 3, 2024

Abstract Background Recent observational studies examining the association between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease (MASLD) have reported conflicting results. We performed a meta‐analysis to quantify magnitude H. MASLD. Methods systematically searched three large electronic databases identify eligible (published up 30 November 2023) in which biopsy, imaging methods or blood‐based biomarkers/scores were used for diagnosing Data from selected extracted, was using common random‐effects modelling. Statistical heterogeneity among published studies, subgroup analyses, meta‐regression analyses publication bias assessed. Results A total 28 (24 cross‐sectional 4 longitudinal studies) identified, including 231 291 middle‐aged individuals predominantly Asian ethnicity (~95%). Meta‐analysis showed that significantly associated with small increase prevalent MASLD ( n = 24 studies; odds ratio 1.11, 95% CI 1.05–1.18; I 2 63%). data an increased developing incident over mean 5‐year follow‐up 1.20, 95%CI 1.08–1.33; 44%). Sensitivity did not modify these The funnel plot reveal any significant bias. Conclusions is mildly Further well‐designed prospective mechanistic are required better decipher complex link

Language: Английский

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Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 30, 2024

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease. Body mass index (BMI) used obesity but has important limitations. The weight-adjusted waist (WWI) a novel metric and accurately reflects body composition. We explored association of WWI with all-cause cardiovascular (CVD) mortality in MASLD. Methods Adult participants MASLD were included from NHANES 1999-2018. was calculated by dividing circumference (WC) square root weight. diagnosed presence hepatic steatosis at least one cardiometabolic risk factor absence other causes steatosis. A fatty ≥60 suggested Mortality data obtained prospectively linking to National Death Index. Multivariate Cox proportional hazards regression analyses explore these associations multiple adjustment models constructed including crude, partial, fully adjusted models. Results After adjusting for all covariates BMI, remained positively linearly associated CVD (hazard ratios [HR] 1.247 1.218, respectively). Higher significantly increased (both p trend <0.05). There an “obesity paradox” between BMI MASLD, lower those overweight/obesity compared normal (HR 0.625 0.596, respectively, = 0.024), no mortality. Interaction indicated that influenced several demographic variables status. Time-dependent receiver operating characteristic curves predictive value higher than WC, waist-to-height ratio across follow-up durations. Conclusions whereas did not reflect risk. provided optimal traditional indicators. These findings emphasize potential use as indicator assessment, stratification, prevention

Language: Английский

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Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120092 - 120092

Published: Sept. 1, 2024

Language: Английский

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Use of non‐invasive diagnostic tools for metabolic dysfunction‐associated steatohepatitis: A qualitative exploration of challenges and barriers

Liver International, Journal Year: 2024, Volume and Issue: 44(8), P. 1990 - 2001

Published: April 18, 2024

Abstract Background and Aims Non‐invasive tests (NITs) are underutilized for diagnosis risk stratification in metabolic dysfunction‐associated steatotic liver disease (MASLD), despite good accuracy. This study aimed to identify challenges barriers the use of NITs clinical practice. Methods We conducted a qualitative exploratory Germany, Italy, United Kingdom States. Phase 1 participants (primary care physicians, hepatologists, diabetologists, researchers, healthcare administrators, payers patient advocates; n = 29) were interviewed. 2 (experts MASLD; 8) took part group discussion validate expand on findings. Finally, we triangulated perspectives hybrid deductive/inductive thematic analysis. Results Four themes hindering emerged: (1) limited knowledge awareness; (2) unclear referral pathways patients affected by conditions; (3) uncertainty over value monitoring managing diseases; (4) justifying system‐level reimbursement. Through these themes, perceived stigma associated with diseases, primary physicians generally lacked awareness, adequate skills recommended NITs. identified uncertainties results NITs, specifically guide lifestyle intervention or that should be referred specialist. Participants indicated an ongoing need research development improve prognostic communicating their cost‐effectiveness payers. Conclusions suggests MASLD is due several individual barriers. Multi‐level interventions likely required address

Language: Английский

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Gut Microbiota and Sinusoidal Vasoregulation in MASLD: A Portal Perspective

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 324 - 324

Published: June 7, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common condition with heterogeneous outcomes difficult to predict at the individual level. Feared complications of advanced MASLD are linked clinically significant portal hypertension and initiated by functional mechanical changes in unique sinusoidal capillary network liver. Early vasoregulatory lead increased intrahepatic vascular resistance represent beginning hypertension. In addition, composition function gut microbiota distinctly different from healthy state, multiple lines evidence demonstrate association dysbiosis these changes. The involved biotransformation nutrients, production de novo metabolites, release microbial structural components, impairment intestinal barrier impact on innate immune responses, metabolism, inflammation, fibrosis, vasoregulation beyond. gut–liver axis conceptual framework which circulation primary connection between Accordingly, biochemical hemodynamic attributes may hold key better understanding predicting progression MASLD. However, many specific details remain hidden due limited access circulation, indicating major unmet need for development innovative diagnostic tools analyze metabolites explore their effect health disease. We also safely reliably monitor hemodynamics goal providing preventive curative interventions all stages Here, we review recent advances that link metabolomics altered allow new insights into

Language: Английский

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