Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

eLife, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 28, 2023

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Why do sex chromosomes progressively lose recombination? DOI
Paul Jay, Daniel L. Jeffries, Fanny E. Hartmann

et al.

Trends in Genetics, Journal Year: 2024, Volume and Issue: 40(7), P. 564 - 579

Published: April 27, 2024

Language: Английский

Citations

13
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Open Access
Christopher S McAllester, John E. Pool

Published: Jan. 23, 2025

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

eLife, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3 R)K L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
The fitness consequences of genetic divergence between polymorphic gene arrangements DOI Creative Commons
Brian Charlesworth

Genetics, Journal Year: 2023, Volume and Issue: 226(3)

Published: Dec. 26, 2023

Inversions restrict recombination when heterozygous with standard arrangements, but often have few noticeable phenotypic effects. Nevertheless, there are several examples of inversions that can be maintained polymorphic by strong selection under laboratory conditions. A long-standing model for the source such is divergence between arrangements respect to recessive or partially deleterious mutations, resulting in a selective advantage heterokaryotypic individuals over homokaryotypes. This paper uses combination analytical and numerical methods investigate this model, simple case an autosomal inversion multiple independent nucleotide sites subject mildly mutations. complete lack heterokaryotypes assumed, as well constancy frequency space time. It shown significantly higher mutational load will develop less frequent arrangement. only expected two alternative nearly equal frequency, so their loads very similar size. The effects some Drosophila pseudoobscura on fitness traits seem too large explained process, although it may contribute observed Several population genomic statistics provide evidence signatures reduced efficacy associated rarer currently little published data relevant theoretical predictions.

Language: Английский

Citations

7
Evolution of chromosomal inversions across an avian radiation DOI Creative Commons
Ulrich Knief, Ingo A. Müller, Katherine Faust Stryjewski

et al.

Molecular Biology and Evolution, Journal Year: 2024, Volume and Issue: 41(6)

Published: May 14, 2024

Chromosomal inversions are structural mutations that can play a prominent role in adaptation and speciation. Inversions segregating across species boundaries (trans-species inversions) often taken as evidence for ancient balancing selection or adaptive introgression, but also be due to incomplete lineage sorting. Using whole-genome resequencing data from 18 populations of 11 recognized munia the genus Lonchura (N = 176 individuals), we identify four large para- pericentric ranging size 4 20 Mb. All cosegregate multiple predate numerous speciation events associated with rapid radiation this clade prehistoric Sahul (Australia, New Guinea) Bismarck Archipelago. coalescent theory, infer trans-specificity is improbable neutrally variation despite substantial sorting characterizing young radiation. Instead, maintenance all three autosomal (chr1, chr5, chr6) best explained by acting along ecogeographic clines not observed collinear parts genome. In addition, sex chromosome inversion largely aligns shows signatures repeated positive both alleles. This study provides trans-species polymorphisms involved It further highlights importance informing inference using null model neutral evolution derived part

Language: Английский

Citations

2
A sex-linked supergene with large effects on sperm traits has little impact on reproductive traits in female zebra finches DOI Creative Commons
Katherine Assersohn, Oscar Morton, Jon Slate

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 291(2019)

Published: March 27, 2024

Despite constituting an essential component of fitness, reproductive success can vary remarkably between individuals and the causes such variation are not well understood across taxa. In zebra finch-a model songbird, almost all in sperm morphology swimming speed is maintained by a large polymorphic inversion (commonly known as supergene) on Z chromosome. The relationship this polymorphism fully understood, particularly for females. Here, we explore effects female haplotype, combination male genotype, several primary traits captive population finches. polymorphism's traits, find no evidence that haplotype influences egg production females or survival embryos through to hatching. However, our findings do reinforce existing heterozygote advantage fitness. This work provides important step understanding species.

Language: Английский

Citations

1
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Open Access
Christopher S McAllester, John E. Pool

Published: Aug. 27, 2024

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 3, 2023

Abstract Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

eLife, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 28, 2023

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0