The promise of music therapy for Alzheimer's disease: A review

Annals of the New York Academy of Sciences, Journal Year: 2022, Volume and Issue: 1516(1), P. 11 - 17

Published: July 18, 2022

Alzheimer's disease (AD) is a progressive neurodegenerative associated with cognitive decline. Memory problems are typically among the first signs of impairment in AD, and they worsen considerably as progresses. However, musical memory partially spared patients despite severe deficits episodic (and partly semantic) memory. AD can learn new songs, encode novel verbal information, react emotionally to music. These effects music have encouraged use development therapy (MT) for management. MT easy implement well-tolerated by most their caregivers. Effects include improved mood, reduced depressive scores trait anxiety, enhanced autobiographical recall, fluency, cognition. Here, we review therapeutic studies using on potential mechanisms underlying those effects. We argue that, because begins decades before presentation clinical symptoms, interventions might be promising means delay decelerate neurodegeneration individuals at risk such genetic or subjective

Language: Английский

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Current Treatments and New, Tentative Therapies for Parkinson’s Disease

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 770 - 770

Published: Feb. 25, 2023

Parkinson’s disease (PD) is a neurodegenerative pathology, the origin of which associated with death neuronal cells involved in production dopamine. The prevalence PD has increased exponentially. aim this review was to describe novel treatments for that are currently under investigation and study possible therapeutic targets. pathophysiology based on formation alpha-synuclein folds generate Lewy bodies, cytotoxic reduce dopamine levels. Most pharmacological target symptoms. These include aimed at reducing accumulation (epigallocatechin), its clearance via immunotherapy, inhibiting LRRK2, upregulating cerebrosidase (ambroxol). continues be pathology unknown generates significant social cost patients who suffer from it. Although there still no definitive cure present, numerous available symptomatology addition other alternatives investigation. However, approach should combination non-pharmacological strategies maximise outcomes improve symptomatological control these patients. It therefore necessary delve deeper into order quality life

Language: Английский

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Music Training and Nonmusical Abilities

Annual Review of Psychology, Journal Year: 2023, Volume and Issue: 75(1), P. 87 - 128

Published: Sept. 22, 2023

Music training is generally assumed to improve perceptual and cognitive abilities. Although correlational data highlight positive associations, experimental results are inconclusive, raising questions about causality. Does music have far-transfer effects, or do preexisting factors determine who takes lessons? All behavior reflects genetic environmental influences, but differences in emphasis-nature versus nurture-have been a source of tension throughout the history psychology. After reviewing recent literature, we conclude that evidence causes nonmusical benefits weak nonexistent, researchers routinely overemphasize contributions from experience while neglecting those nature. The literature also largely exploratory rather than theory driven. It fails explain mechanistically how music-training effects could occur ignores far transfer rare. Instead focusing on elusive benefits, argue it more fruitful examine social-emotional engaging with music, particularly groups, music-based interventions may be effective mainly for clinical atypical populations.

Language: Английский

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Cognitive Crescendo: How Music Shapes the Brain’s Structure and Function

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(10), P. 1390 - 1390

Published: Sept. 29, 2023

Music is a complex phenomenon with multiple brain areas and neural connections being implicated. Centuries ago, music was discovered as an efficient modality for psychological status enrichment even the treatment of pathologies. Modern research investigations give new avenue perception understanding underlying neurological mechanisms, using neuroimaging, especially magnetic resonance imaging. Multiple were depicted in last decades high value processing, further analyses neuropsychology field uncover implications emotional cognitive activities. listening improves functions such memory, attention span, behavioral augmentation. In rehabilitation, music-based therapies have rate success depression anxiety disorders regaining body integrity after stroke episode. Our review focused on music, well presenting significant clinical relevance music.

Language: Английский

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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 16, 2024

Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired reasoning. It the leading cause of dementia in older adults, marked pathological accumulation amyloid-beta plaques neurofibrillary tangles. These changes lead to widespread neuronal damage, significantly impacting daily functioning quality life.

Language: Английский

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Sensogenomics of music and Alzheimer’s disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Feb. 3, 2023

Introduction The relationship between music and Alzheimer’s disease (AD) has been approached by different disciplines, but most of our outstanding comes from neuroscience. Methods First, we systematically reviewed the state-of-the-art neuroscience cognitive sciences research on AD (>100 studies), progress made therapeutic impact stimuli in memory. Next, meta-analyzed transcriptomic epigenomic data patients to search for commonalities with genes pathways previously connected genome association, epigenetic, gene expression studies. Results Our findings indicate that >93% neuroscience/ studies at least one beneficial effect neurodegenerative diseases, being improvements memory cognition frequent outcomes; other common benefits were social behavior, mood emotion, anxiety agitation, quality life, depression. Out 334 music-related genes, 127 (38%) found be linked epigenome/transcriptome analysis (vs. healthy controls); some them ( SNCA, SLC6A4, ASCC2, FTH1, PLAUR ARHGAP26 ) have reported associated e.g. musical aptitude transcriptome. Other GMPR, SELENBP1 ADIPOR1 neuropsychiatric, diseases performance, emerged as hub consensus co-expression modules detected estimulated transcriptomes. In addition, connections music, dopamine related SCNA remarkable – a learning memory, disorders (e.g., Parkinson’s AD). Discussion present study vast majority neuroscientific unambiguously show health, relevant disease. These illuminate new roadmap genetic neurosciences, interventions conditions.

Language: Английский

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Multifaceted Music Therapy for Depression in Dementia: A Network Meta-Analysis of Randomized Controlled Trials

European Journal of Investigation in Health Psychology and Education, Journal Year: 2024, Volume and Issue: 14(2), P. 351 - 367

Published: Feb. 11, 2024

This study aimed to assess the efficacy of various music therapy interventions in ameliorating depressive symptoms dementia patients, utilizing a network meta-analysis approach. We rigorously selected randomized controlled trials focused on for with from major electronic databases. The primary outcome measured was impact symptoms, secondary evaluating dropout rates across different intervention groups and standard care control groups. research protocol has been duly registered PROSPERO (Registration ID: CRD42023393059). Our incorporated 14 involving total 1080 participants examined range interventions, including active therapy, listening music, rhythmic singing, tailored interventions. analysis revealed that combined singing emerged as most effective intervention, demonstrating significant improvement patients (Standardized Mean Difference [SMD] = −0.89, 95% Confidence Interval [CI]: −1.48 −0.30). In contrast, alone showed smaller effect (SMD −0.26, CI: −0.71 0.20). particularly noteworthy not showing higher compared care, indicating its feasibility acceptability clinical settings. findings our indicate is an approach reducing potentially due enhanced social interaction. These results offer new perspectives suggesting promising direction further application.

Language: Английский

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The impact of group music therapy in ameliorating the depression among patients with dementia in care homes: A randomized control trial

Geriatric Nursing, Journal Year: 2024, Volume and Issue: 56, P. 304 - 311

Published: Feb. 27, 2024

Language: Английский

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Exploring Intervention Techniques for Alzheimer’s Disease: Conventional Methods and the Role of AI in Advancing Care

Artificial Intelligence and Applications, Journal Year: 2024, Volume and Issue: unknown

Published: April 7, 2024

Alzheimer’s disease (AD) is a neurodegenerative condition characterized by cognitive decline and functional impairment. This study compares conventional intervention techniques with emerging artificial intelligence (AI) approaches to AD. Intervention technique refers specific method or approach employed bring about positive change in particular situation. In the context of AD, such are crucial as they aim slow down progression symptoms, alleviate behavioral challenges, support patients their caretakers managing complexities condition. Conventional techniques, stimulation reality orientation, have demonstrated benefits improving function emotional well-being. widely preferred proven track record effectiveness, personalized response, cost-effectiveness, patient-centered care. Despite these benefits, limited individual variability response long-term effectiveness. On other hand, AI-based computer vision deep learning hold potential revolutionize interventions. These technologies offer early detection, care, remote monitoring capabilities. They can provide tailored interventions, assist decision-making, enhance caregiver support. Although interventions face challenges data privacy implementation complexity, transform care significant. research paper approaches. It reveals that while traditional well established novel opportunities for advanced Combining strengths both may lead more comprehensive effective individuals Continued collaboration harness full AI enhancing quality life affected caregivers.

Language: Английский

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Comparative efficacy of seven nonpharmacological interventions on global cognition in older adults with and without mild cognitive impairment: a network meta-analysis of randomized controlled trials

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 10, 2024

Abstract To maintain current cognitive function and access greater reserves, nonpharmacological interventions may be a viable alternative for older adults with or without impairment. This study aimed to compare different enhancing global cognition, including mind–body exercise, physical non-invasive brain stimulation, training intervention (CTI), acutherapy (ACU), meditation, music therapy, by applying network meta-analysis (NMA). Sixty-one randomized controlled trials evaluating the efficacy of on cognition in mild decline were selected. An NMA was conducted interventions. The revealed that exercise (standardized mean difference, 1.384; 95% confidence interval, 0.777–1.992); ACU (1.283; 0.478–2.088); meditation (0.910; 0.097–1.724); stimulation (1.242; 0.254–2.230); CTI (1.269; 0.736–1.802); (0.977; 0.212–1.742), showed positive effects compared passive controls. There no significant differences between efficacies other Nonpharmacological potentially enhance through various pathways, such as memorizing movements plasticity reducing stress adult population. Additional studies are needed clarify impact variables, methods psychological variables.

Language: Английский

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