The Bidirectional Relationship between Periodontal Disease and Diabetes Mellitus—A Review

Diagnostics, Journal Year: 2023, Volume and Issue: 13(4), P. 681 - 681

Published: Feb. 11, 2023

Periodontitis is a chronic inflammatory disease caused by the presence of bacterial biofilm known as dental plaque. This affects supporting apparatus teeth, especially periodontal ligaments and bone surrounding teeth. Periodontal diabetes seem to be interrelated in bidirectional relationship, have been increasingly studied recent decades. For example, mellitus has detrimental effect on disease, increasing its prevalence, extent, severity. In turn, periodontitis negatively glycemic control course diabetes. review aims present most recently discovered factors that contribute pathogenesis, therapy, prophylaxis these two diseases. Specifically, article focuses microvascular complications, oral microbiota, pro- anti-inflammatory diabetes, disease. As presented this review, diseases require specific/ complementary therapeutic solutions when they occur association, with new clinical trials epidemiological research being necessary for better interdependent pathogenic topic.

Language: Английский

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Diabetes mellitus promotes susceptibility to periodontitis—novel insight into the molecular mechanisms

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 16, 2023

Diabetes mellitus is a main risk factor for periodontitis, but until now, the underlying molecular mechanisms remain unclear. can increase pathogenicity of periodontal microbiota and inflammatory/host immune response periodontium. Hyperglycemia induces reactive oxygen species (ROS) production enhances oxidative stress (OS), exacerbating tissue destruction. Furthermore, alveolar bone resorption damage epigenetic changes in induced by diabetes may also contribute to periodontitis. We will review latest clinical data on evidence promoting susceptibility periodontitis from epidemiological, mechanistic, potential therapeutic targets discuss possible mechanistic targets, focusing particular novel OS. Understanding intertwined pathogenesis explain cross-interference between endocrine metabolic inflammatory diseases better, provide theoretical basis new systemic holistic treatment, promote interprofessional collaboration physicians dentists.

Language: Английский

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Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 4, 2023

Diabetes and associated comorbidities are a global health threat on the rise. We conducted six-month dietary intervention in pre-diabetic individuals (NCT03222791), to mitigate hyperglycemia enhance metabolic health. The current work explores early diabetes markers 200 who completed trial. find 166 of 2,803 measured features, including oral gut microbial species pathways, serum metabolites cytokines, show significant change response personalized postprandial glucose-targeting diet or standard care Mediterranean diet. These changes include established as well novel features that can now be investigated potential therapeutic targets. Our results indicate microbiome mediates effect glycemic, immune measurements, with compositional explaining 12.25% variance. Although displays greater compared microbiome, demonstrates more at genetic level, trends dependent environmental richness prevalence population. In conclusion, our study shows interventions affect cardiometabolic profile host, these factors each other, harnessed for new modalities.

Language: Английский

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Distribution and Characteristics of Oral Pathogens According to Blood Glucose Levels in South Korean Health Examinees

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2638 - 2638

Published: March 14, 2025

The distribution of oral pathogens is influenced by genetic background, diet, socioeconomic status, and racial factors. This study aimed to assess the characteristics based on blood glucose levels in a South Korean population. cross-sectional, retrospective included subjects from 17 health promotion centers 13 cities between November 2021 December 2022. Real-time multiplex PCR was used detect 10 periodontitis-related pathogens, 6 dental caries-related 1 caries-protective bacterium. most prevalent were Parvimonas micra (97.6%), Porphyromonas endodontalis (96.8%), Treponema socranskii (95.0%). Among Streptococcus sanguinis Veillonella parvula found all subjects. prevalence higher males, while related periodontitis caries more older individuals. In diabetes group, Aggregatibacter actinomycetemcomitans, red orange complexes, mutans prevalent. relative amount S. lower, V. individuals with mellitus. composition vary sex, age, levels. Diabetic showed pathogenic community structure linked increased risks caries.

Language: Английский

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The bidirectional biological interplay between microbiome and viruses in periodontitis and type-2 diabetes mellitus

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 5, 2022

Periodontitis was an inflammatory disease associated with a dysbiosis of the oral flora characterized by chronic sustained inflammation inducing resorption alveolar bone and leading to tooth loss. Type 2 diabetes mellitus (T2D) metabolic caused impaired insulin action. The microbiome played crucial role in modulating both innate adaptive immune system during trigger exacerbation periodontitis T2D. bidirectional relationship T2D had been focus intensive research, but those were not well explored. In this commentary, in-depth analysis changes bacterial metabolites or without described. promotion might involve factors/receptors, oxidative stress, microRNA so on. effect on adipose factor pathway, AGE/RAGE RANK/RANKL pathway etc. Generally, are closely related microecological-epithelial interaction, soft tissue degradation, coupling disorder, regulation gene transcription. viruses, including HBV, HCV, HSV-1, Coronavirus, HCMV, EBV, HIV, phageome on, important development periodontitis. An understanding between host great significance clarify mechanisms, suggesting that remission will have positive impact other.

Language: Английский

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A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis

Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 315 - 315

Published: Feb. 8, 2024

This mapping review highlights the need for a new paradigm in understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on relationship between biofilm, inflammation, biology. close interactions immune cells are discussed, with multiple stable states likely existing clinically observable definitions peri-implant health peri-implantitis. framework presented aims to explain transition from disease as staged incremental process, where factors contribute distinct steps towards tipping point manifested clinically. These might be reached different ways patients may constitute highly individualised paths. Notably, affecting underlying biology identified pathogenesis peri-implantitis, highlighting that disruptions host–microbe homeostasis at implant–mucosa interface not sole factor. An improved will allow intervention levels personalised treatment approach. Further research areas identified, such use novel biomarkers detect changes macrophage polarisation activation status, turnover.

Language: Английский

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Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population

Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 15, 2024

Objective To investigate the associations of oral microbiome status with diabetes characteristics in elderly patients type 2 mellitus.

Language: Английский

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Oral microbiota in periodontitis patients with and without type 2 diabetes mellitus and their shifts after the nonsurgical periodontal therapy

Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e22110 - e22110

Published: Nov. 1, 2023

ObjectiveTo investigate the shift in oral microbiota of periodontitis patients with and without type 2 diabetes mellitus (T2DM) undergoing nonsurgical periodontal treatment its implications.MethodsEleven chronic eleven from Second Affiliated Hospital Chongqing Medical University received were re-evaluated 3 months later. DNA saliva subgingival plaques was amplified sequenced using 16S ribosomal RNA (16S rRNA) gene sequencing for microbiome profiling. Clinical indexes at onset after therapy recorded compared.ResultsThe species richness dominant T2DM changed significantly both plaques. The condition also effectively improved three therapy. Glycemic control improved. Additionally, could increase microbial diversity proportion health-associated bacteria but a proportional reduction pathogenic T2DM. Network analysis revealed fewer links lower level centralization (CP) group treatment. However, more higher network density networks found CP + group, suggesting stable community treatment.ConclusionsThere significant differences structural composition reaction to between Nonsurgical can improve metabolic control, decrease pathogens conditions, help stabilize communities Furthermore, may be potential supplementary approach managing

Language: Английский

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Bacterial Communities and Their Role in Bacterial Infections

Frontiers in Bioscience-Elite, Journal Year: 2024, Volume and Issue: 16(4)

Published: Dec. 3, 2024

Since infections associated with microbial communities threaten human health, research is increasingly focusing on the development of biofilms and strategies to combat them. Bacterial may include bacteria one or several species. Therefore, examining all microbes identifying individual community responsible for infectious process important. Rapid accurate detection bacterial pathogens paramount in healthcare, food safety, environmental monitoring. Here, we analyze biofilm composition describe main groups whose presence a leads infection (Staphylococcus aureus, Enterococcus spp., Cutibacterium HACEK, etc.). Particular attention paid that can lead device-associated infections, damage, disruption normal functioning medical devices, such as cardiovascular implants, biliary stents, neurological, orthopedic, urological penile etc. Special consideration given tissue-located oral cavity, lungs lower respiratory tract, upper middle ear, system, skeletal wound surface, urogenital system. We also methods used biofilms, microbiologically testing, staining, microcolony formation, cellular extracellular components, other methods. Finally, present ways reduce incidence biofilm-caused infections.

Language: Английский

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Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

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