Association between healthy lifestyle combinations and periodontitis in NHANES

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 4, 2024

Abstract Background Periodontitis is closely associated with chronic systemic diseases. Healthy lifestyle interventions have health-enhancing effects on disorders and periodontitis, but the extent to which healthy combinations are periodontitis unclear. Therefore, this study aimed investigate association between different combinations. Methods 5611 participants were included from National Health Nutrition Examination Survey (NHANES, 2009–2014). Six lifestyles factors defined as fulfilling either: non-smoking, moderate drinking, body mass index (BMI), physical activity, sleep appropriate total energy intake. Then, adjusted logistic regression models performed identify scoring system composed of six (0–6 scale). Finally, scenarios dynamically randomly combined optimal personalized combination mode. Results Higher scores significantly lower prevalence ( p < 0.05). Four (smoking, BMI, sleep) varied groups Smoking was considered a strong independent risk factor for in both former current smokers. further indicated that these four played most essential role determining magnitude occurrence (odds ratio [OR]: 0.33; 95% confidence interval [CI]: 0.21 0.50). In population, majority three outperformed two models, whereas two-combination nonsmoking-drinking (OR: 0.39; CI: 0.27 0.58) had relatively than three-combination drinking-BMI-sleep 0.42; 0.26 0.66). Conclusion This cross-sectional suggests smoking, related smoking principal among them. provides various customized prevention.

Language: Английский

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Nel-like Molecule Type 1 Combined with Gold Nanoparticles Modulates Macrophage Polarization, Osteoclastogenesis, and Oral Microbiota in Periodontitis

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 8442 - 8458

Published: Feb. 9, 2024

The disruption of host–microbe homeostasis and uncontrolled inflammatory response have been considered as vital causes for developing periodontitis, subsequently leading to an imbalance between the bone immune system collapse homeostasis. Consequently, strategies modulate metabolization become a promising approach prevent treat periodontitis. In this study, we investigated cooperative effects Nel-like molecule type 1 (Nell-1) gold nanoparticles (AuNPs) on macrophage polarization, osteoclast differentiation, corresponding functions in experimental model periodontitis rats. Nell-1-combined AuNPs vitro studies were found reduce production factors (TNF-α, p < 0.0001; IL-6, = 0.0012), ratio M2/M1 macrophages by inducing polarization into M2 phenotype, inhibit cell fusion, maturation, activity osteoclasts. Furthermore, local application vivo resulted alleviation damages periodontal tissues, modulation osteoclasts, alteration microbiota, which relative abundance probiotic Bifidobacterium increased (p 0.05). These findings reveal that could be drug candidate prevention treatment However, did not show organ toxicity or impair integrity intestinal epithelium but alter gut dysbiosis microbiota. adverse impact changes microbiota needs further investigated. Nonetheless, study provides novel perspective direction biological safety assessment biomaterials oral clinical applications.

Language: Английский

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Advances in Hydrogels for Periodontitis Treatment

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 2742 - 2761

Published: April 19, 2024

Periodontitis is a common condition characterized by bacterial infection and the disruption of body's immune-inflammatory response, which causes damage to teeth supporting tissues eventually results in tooth loss. Current therapy involves systemic local administration antibiotics. However, existing treatments cannot exert effective, sustained release maintain an effective therapeutic concentration drug at lesion site. Hydrogels are used treat periodontitis due their low cytotoxicity, exceptional water retention capability, controlled profile. can imitate extracellular matrix periodontal cells while offering suitable sites load This article reviews utilization hydrogels for based on pathogenesis clinical manifestations disease. Additionally, latest strategies smart main techniques hydrogel preparation have been discussed. The information will aid designing preparing future treatment.

Language: Английский

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Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111796 - 111796

Published: March 1, 2024

Language: Английский

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Independent and combined effects of smoking, drinking and depression on periodontal disease

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 6, 2024

Abstract Background Periodontitis is a complex chronic inflammatory disease that particularly associated with health-related conditions such as smoking, excessive drinking and depression. This research aimed to investigate the interaction between these lifestyles factors on periodontitis risk. Methods study included participants who participated in National Health Nutrition Examination Survey United States 2009 2014. They had completed oral health-periodontal examination, Smoking-Cigarette Use Questionnaire, Alcohol Patient Questionnaire. Periodontal clinical attachment loss (CAL) of 3 mm or more Questionnaire-9 (PHQ-9) 10 scores were used identify depression, respectively. Daily alcohol consumption past year was classified into three levels: low (1 drink less), moderate (between 1 drinks), heavy (4 drinks more), while smoking defined having smoked at least 100 cigarettes one's lifetime. Then, logistic regression combined models analyze independent effects depression Results The results indicated statistically significant multiplicative relation development periodontitis, both overall population ( P = 0.03) among male 0.03). Furthermore, individuals experiencing found significantly increase prevalence by 129% younger age group compared non-smokers (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.10 4.76). However, only females < 0.05). There dose-dependent relationship frequency prevalence. In population, occasional (OR: 1.70; CI: 1.22 2.37) regular 2.28; 1.68 3.11) increased without two factors. Conclusion These suggested there interactive risk policies healthy behaviours mental health may be beneficial for our health.

Language: Английский

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Correlation between Periodontitis and Gastritis Induced by Helicobacter Pylori: A Comprehensive Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1579 - 1579

Published: Aug. 2, 2024

The goal of this comprehensive review was to verify if the prevalence

Language: Английский

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Periodontitis and COVID-19: Immunological Characteristics, Related Pathways, and Association

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 3012 - 3012

Published: Feb. 3, 2023

Both periodontitis and Coronavirus disease 2019 (COVID-19) pose grave threats to public health social order, endanger human life, place a significant financial strain on the global healthcare system. Since COVID-19 pandemic, mounting research has revealed link between periodontitis. It is critical comprehend immunological mechanisms of two illnesses as well their interaction. Much evidence showed that there are many similar inflammatory pathways COVID-19, such NF-κB pathway, NLRP3/IL-1β IL-6 signaling pathway. Common risk factors gender, lifestyle, comorbidities contribute severity both diseases. Revealing internal relationship diseases conducive treatment in an emergency period. also maintain good oral hygiene positive attitude during treatment. This review covers four main areas: mechanisms, common factors, association diseases, possible interventions potential targets. These will provide ideas for drug development clinical

Language: Английский

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Herpesvirus‐Bacteria pathogenic interaction in juvenile (aggressive) periodontitis. A novel etiologic concept of the disease

Periodontology 2000, Journal Year: 2023, Volume and Issue: 94(1), P. 532 - 538

Published: June 21, 2023

Abstract Localized juvenile (aggressive) periodontitis starts at puberty in otherwise healthy individuals and involves the proximal surfaces of permanent incisors first molars. The disease destroys a sizeable amount periodontal bone within few months despite minimal dental plaque gingival tissue inflammation. Cytomegalovirus Epstein–Barr virus, as well two main periodontopathic bacteria Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis , are linked to periodontitis. Juvenile periodontitis‐affected teeth show cementum hypoplasia. We hypothesize that an active herpesvirus infection, time root formation, hampers formation and, puberty, reactivation triggers upgrowth bacterial pathogens which produce rapid destruction on with defective periodontium. A pathogenic interaction between herpesviruses can potentially explain etiology incisor‐first molar destructive pattern Effective treatment may target herpesvirus‐bacteria co‐infection.

Language: Английский

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Photothermal therapy of copper incorporated nanomaterials for biomedicine

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Studies have reported on the significance of copper incorporated nanomaterials (CINMs) in cancer theranostics and tissue regeneration. Given their unique physicochemical properties tunable nanostructures, CINMs are used photothermal therapy (PTT) photothermal-derived combination therapies. They potential to overcome challenges unsatisfactory efficacy conventional therapies an efficient non-invasive manner. This review summarizes recent advances CINMs-based PTT biomedicine. First, classification structure introduced. tumors guided by multiple imaging modalities then reviewed. Various representative designs bone, skin other organs presented. Furthermore, biosafety is discussed. Finally, this analysis delves into current that researchers face offers optimistic outlook prospects clinical translational research field. aims at elucidating applications derived biomedicine encourage future design translation.

Language: Английский

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Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway

Molecular Medicine Reports, Journal Year: 2023, Volume and Issue: 28(5)

Published: Sept. 22, 2023

Macrophage pyroptosis and related inflammatory responses play an important role in periodontitis. Kynurenic acid (KA) is hypothesized to have anti‑inflammatory potential, but whether KA can inhibit macrophage the underlying mechanisms remain unclear. Lipopolysaccharide (LPS) was used induce THP‑1‑derived macrophages. or ML385 pretreat macrophages, after which, cell viability, NOD‑like receptor protein 3 (NLRP3) inflammasome‑related expression, oxidative stress levels nuclear factor erythroid 2‑related 2 (NRF2) expression were measured. The results showed that improved LPS‑induced decrease viability lactate dehydrogenase release. prevented THP‑1 induced by LPS reducing of NLRP3, Gasdermin‑D, Caspase1, decreased factors. suppressed NLRP3 inflammasome activation inhibiting ROS overproduction increasing Heme Oxygenase 1 glutathione levels. Moreover, promoted NRF2 translocation from cytoplasm nucleus. In addition, anti‑pyroptotic antioxidant effects reversed inhibition NRF2. present study, it found significantly LPS. It further demonstrated mediated pathway.

Language: Английский

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