Relationship between oral microbiota and colorectal cancer: A systematic review

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Abstract This systematic review aims to investigate the microbial basis underlying association between oral microbiota and colorectal cancer. A comprehensive search was conducted across four databases, encompassing potentially relevant studies published up April 2024 related PECO question: “Is there a differentiation in composition adult patients diagnosed with cancer compared healthy patients?”. The Newcastle‐Ottawa Scale used evaluate quality of included. level evidence assessed through GRADE (Grading Recommendations, Assessment, Development Evaluation) tool. Sixteen fulfilled eligibility criteria. Based on low moderate profile, high levels certain subspecies within Firmicutes (such as Streptococcus anginosus , Peptostreptococcus stomatis S. koreensis gallolyticus ), Prevotella intermedia Fusobacterium nucleatum Neisseria oralis were found be associated Conversely, bacteria (e.g., Lachnospiraceae F. periodonticum P. melaninogenica ) could exert symbiotic protective effect against existing evidence, it appears that variations exist among individuals without However, further research is necessary determine mechanisms dysbiosis carcinogenesis.

Language: Английский

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Association between Periodontal Diseases and the Risk of Site-Specific Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

Journal of Dental Research, Journal Year: 2024, Volume and Issue: 103(10), P. 962 - 972

Published: Aug. 26, 2024

The association between periodontal diseases and the risk of gastrointestinal cancers, especially site-specific remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web Science, Google Scholar from inception to April 2024 identify relevant studies. pooled hazard ratios (HRs) 95% confidence intervals (CIs) were calculated with a random-effects model. Subgroup analyses sensitivity conducted confirm robustness main findings in different populations. This study was reported according PRISMA 2020 guidelines. In total, identified 19 studies, including 16.6 million participants. Individuals had an increased overall cancers compared those without (HR 1.31, CI 1.16-1.49). Periodontal significantly esophageal cancer by 39% 1.39, 1.15-1.68), gastric 13% 1.13, 1.01-1.26), colorectal 21% 1.21, 1.05-1.39), pancreatic 35% 1.35, 1.00-1.82), liver 9% 1.09, 1.04-1.13). periodontitis 1.45, 1.14-1.85), gingivitis 1.03, 1.01-1.04), periodontitis/gingivitis 1.27, 1.07-1.51). Furthermore, severe showed 1.79, 1.07-2.99). Results for robust findings. summary, diseases, periodontitis, increase cancers. Interventions prevent manage may reduce developing

Language: Английский

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The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 21, 2025

Background Periodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of teeth triggered by bacterial infection and is recognized promote systemic inflammation, leading dysfunction in specific organs. Adverse pregnancy outcomes (APOs), including preterm birth, small for gestational age infants, diabetes preeclampsia, are linked complications. Recently, correlation between periodontal adverse has garnered global attention. However, bibliometric studies this area remain limited. This study aimed visualize knowledge framework research trends concerning relationship from 2000 2023 through approaches. Methods On September 22, 2024, articles reviews on connection were retrieved Web Science Core Collection (WOSCC). CiteSpace [6.3.R1 (64-bit) Advanced] was used perform mapping studies. Results Over past 23 years, 932 73 countries collected, with U.S. contributing over one-third (355), followed Brazil (85) India (59). The literature field experienced multiple growth phases since 2000, particularly rapid observed after 2019. University North Carolina ( n = 34, 3.65%) institution terms publication output, primarily representing Notably, Journal Periodontology American Obstetrics Gynecology most frequently cited journals fields periodontology obstetrics, respectively. These publications authored 94 researchers, Steven Offenbacher being both productive highly author, making significant contributions field. A visual analysis keywords identifies “oral microbiota,” health,” “adverse outcomes,” “global burden” as emerging hotspots exploring outcomes. Conclusions first offers concise overview suggests future should focus risk factors, high-risk populations, oral microbiota, mechanisms, interventions, international collaboration.

Language: Английский

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Causal relationship between periodontitis and prostate diseases: a bidirectional Mendelian randomization study

Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(2)

Published: Feb. 13, 2025

Language: Английский

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Advanced biomaterials for targeting mature biofilms in periodontitis therapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

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The role of cellular lipid metabolism and lipid-lowering drugs in periodontitis

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114434 - 114434

Published: March 13, 2025

Language: Английский

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The Oral Microbiome and Cancer

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 151 - 170

Published: Jan. 1, 2025

Language: Английский

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Identification of potential shared gene signatures between periodontitis and breast cancer by integrating bulk RNA-seq and scRNA-seq data

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Studies have shown that patients with periodontitis (PD) an increased risk of breast cancer (BC). However, the exact mechanism remains to be further investigated. This study aimed investigate genes, pathways and immune cells may interact PD BC. From Gene Expression Omnibus (GEO) TCGA databases, we retrieved gene expression profiles samples BC, respectively. Common genes between two diseases were found using differential analysis weighted co-expression network (WGCNA). Machine learning methods used find shared diagnostic genes. Single-sample GSEA (ssGSEA) was performed 28 in single-cell RNA sequencing (scRNA-seq) data visualize localization Finally, employed qRT-PCR immunohistochemistry staining confirm hub diseases. BC had 21 crosstalk which primarily related peptide hormone response, organic acid transmembrane transport, carboxylic transport. By machine methods, ANKRD29 TDO2 most efficient biomarkers, confirmed by Immunohistochemical qRT-PCR. ssGSEA showed immunology involved both mediating cells. scRNA-seq confirms importance these regulating immunity In brief, our identified 2 serve as biomarkers targets for diagnosis treatment

Language: Английский

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Porphyromonas gingivalis -OMVs promote the epithelial-mesenchymal transition of oral squamous cell carcinoma by inhibiting ferroptosis through the NF-κB pathway

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 3, 2025

Recent studies reported the role of Porphyromonas gingivalis (P. g) in promoting oral squamous cell carcinoma (OSCC) progression. However, molecular mechanism remains unclear. P. g-OMVs were isolated using ultracentrifugation method and characterized by transmission electron microscopy (TEM) nanoparticle tracking analysis (NTA). CCK-8, migration, invasion, Quantitative real-time Polymerase Chain Reaction (qRT-PCR) immunocytochemistry assays performed to evaluate effect on tumor cells' proliferation, epithelial-mesenchymal transition (EMT), ferroptosis vitro. Western blot was study phosphorylation transcription factor nuclear kappa B (NF-κB). In vivo, growth OSCC evaluated a xenograft model, followed hematoxylin eosin immunohistochemistry staining. TEM NTA demonstrated that have vesicular structure with particle size around 118 nm. Compared control group, significantly enhance invasion cells. addition, promote EMT cells, which can be attenuated activator erastin. Moreover, inhibit feroptosis activating NF-κB signaling. OSCC. Inhibition could significnatly reduce OSCC, further rescued inhibitor Ferrostain-1. progression modulating ferroptosis-related through

Language: Английский

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The effect of periodontal treatment on Helicobacter pylori-infection: a systematic review

Deleted Journal, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 10, 2025

Abstract Helicobacter pylori ( H. ), a bacterium widely distributed in the world's population, represents most common cause of chronic gastritis and main risk factor for stomach cancer. The obstacle to eradication is antibiotic resistance, therefore new therapeutic strategies are necessary. Recently, periodontitis has been correlated with several systemic diseases, including -associated gastritis. pathogenetic link between these two diseases inflammation induced by bacteria oral cavity stomach. This systematic review aims evaluate benefits non-surgical periodontal treatment (NSPT) on eradication. PubMed, Scopus, Web Science, Cochrane were searched using MESH terms “Helicobacter pylori” “periodontal treatment”, “periodontal”, “scaling root planning” from January 2015 2025, leading 11 records included final analysis. treatments evaluated studies scaling planing mouthwashing, addition protocols (HPE). A quality assessment risk-of-bias also performed. There evidence that patients infection benefit NSPT. limitations examined small samples, short follow-up, few numbers randomized controlled trials. According our data, NSPT might be HPE guidelines.

Language: Английский

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