Q‐Switched 785 nm laser in the treatment of labial melanotic macules DOI Creative Commons

Giustino Gallo,

Shady M. Ibrahim, Beatrice Marina Pennati

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Jan. 1, 2024

Physiological lip melanosis is a disorder with multifactorial aetiology. It varies ethnicity and typical of people darker skin tones. Benign conditions (ephelides, lentigines, labial melanotic macule), malignant instances (pigmented squamous cell carcinoma, melanoma), drug-induced, post-inflammatory hyperpigmentation (PIH), endocrine disorders, heavy metals, smoking, amalgam tattoo, Laugier-Hunziker syndrome lentiginosis syndromes (Peutz–Jegher's syndrome) are among the factors that can cause pigmentation macules pigmented benign linear increase in pigment basal layer without any melanocyte proliferation vascular component.1 Although treatment not needed, it requested by many patients, who greatly distressed this condition. For melanosis, there is, unfortunately, no effective treatment.2 Patients frequently experiment whitening creams, camouflage lipsticks tattoos getting desired outcome.3 Histological evidence darkening shows abnormal melanin granule aggregation regular number melanocytes an excess dermal melanophages.4 These good targets for Q-switched (QS) lasers because they contain which interested chromophore. This way, collateral tissue damage be reduced. has been demonstrated QS 532-nm laser works perfectly to treat hyperpigmented lips. Nevertheless, negative effects more common, last longer intense than 1064-nm laser.5 The picosecond emit pulses much shorter target's thermal relaxation time so raise peak temperature inflicting on nearby tissues. Given this, study aimed conduct preliminary assessment application 785 nm handpiece (El.En Group, Florence, Italy) hyperpigmentation, minimize blood absorption maximize melanin. A 51-year-old male patient lower subject case study. parameters were spot size 3 mm, fluence 2.8 J/cm2, frequency 2 Hz single pass modality. To get most out technology, contact sensor was included device. follow-up appointments conducted 24 h 14 days following treatment. Our findings indicate patient's mucosa very quickly almost completely recovered, when compared (see Figure 1). Additionally, given visual analogue scale (VAS) range 1 10 value he reported indicated high degree (VAS = 9) satisfaction complete disappearance hyperpigmentation. According Loh et al. (2021), may preferred wavelength treating lesions types. On other hand, 730 emitting devices preferable lightly coefficient at expected 30% higher nm.6 Furthermore, due melanin's over haemoglobin, better 1064 532 targeting or pigment.7 Indeed, we treated different unusual body district such as internal part lip. unique characteristics being component-rich area. Of course, strategies could have used target melanin, 675 532/1064 lasers, previously investigations.8 clinical presented decided conservative approach during treatment, focus component only avoid one. side registered, pain-free bearable patient. Oral healing happens way faster healing. networks related wounds oral regulate inflammatory responses epithelial differentiation.9 In summary, use our warranted improve absorption. confirmed device utilized safety record. nearly elimination ability resume normal activities soon sessions concluded contributed level technology also had benefit having long-term pain.

Language: Английский

Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation DOI Creative Commons
Farnoosh Seirafianpour, Najmolsadat Atefi, Nazila Ghoreishi Amin

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Introduction Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies types. While modifying exacerbating habits can provide partial relief for the pigmentary vascular factors associated this condition, despite abundance of available treatment options, there is currently lack gold‐standard evidence‐based treatments proposed curing disorder. Objectives This study aimed to assess safety effectiveness carboxytherapy in treating hyperpigmentation. Material Methods In 4‐week single‐arm clinical trial, 20 eligible Iranian patients symmetric received weekly intradermal carboxytherapy. The involved administering 10–20 mL CO2 at rate mL/min temperature 15°C duration ranging from few seconds 1 min. Follow‐up assessments were conducted month after final session. primary outcome was defined as changes ΔE variations pigmentation observed between orbital extra‐orbital skin before trial. Results reported satisfaction statistically significant reduction achieved through lateral ( p = 0.002), middle 0.001), medial 0.001) regions area. total response estimated 20%. Patient exceeded changes, no linear relationship 0.084). Conclusion Carboxytherapy be an effective safe

Language: Английский

Citations

6
Clinical evidence of high-power 675 nm laser system equipped with a faster treatment modality for the management of pigmented lesions and skin rejuvenation. DOI Creative Commons

Massimo DF Vitale,

Francesca Madeddu, Irene Fusco

et al.

JAAD Case Reports, Journal Year: 2025, Volume and Issue: 58, P. 93 - 98

Published: Feb. 4, 2025

Language: Английский

Citations

0
Efficacy and Safety of 1064‐nm Nanosecond Laser Modalities (Q‐NDY and MDF Handpieces) for Treating Hand Skin Aging: A Prospective Randomized Controlled Trial DOI Creative Commons
Jiying Dong,

Shanshan Yao,

Wang Shen

et al.

Dermatologic Therapy, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background and Objectives: Hand aging is complex, while laser treatments effectively address pigmentation, their precise impact on skin thickness wrinkles remains unclear. This study evaluates the effects of two 1064‐nm nanosecond modalities (Q‐switched Nd:YAG (Q‐NDY) multidepth fractional (MDF)) hand rejuvenation safety. Materials Methods: A randomized controlled trial involving 20 patients with signs was conducted. Participants were to Q‐NDY or MDF group, receiving three at four‐week intervals, followed by a three‐month follow‐up. Outcomes evaluated independent plastic surgeons using an observer‐reported scale. Skin physiology (thickness, melanin, erythema indices) measured, patient satisfaction assessed scale (PSS). Results: Both improved pigmentation reduced wrinkles. The group showed significantly greater improvement in fine ( p = 0.0086) texture 0.0209) significant increase < 0.01), whereas did not. Melanin indices decreased week 20, reduction 0.021). Overall 75% for 90% MDF. Conclusion: rejuvenate skin. mode superior outcomes wrinkle reduction, texture, thickness, offering safe effective treatment option rejuvenation. Trial Registration: Chinese Registry Clinical Trials: MR‐31‐23‐013044

Language: Английский

Citations

0
Comparison of the Efficacy of 1064‐ and 730‐nm Picosecond Lasers for Acquired Dermal Melanocytosis DOI Creative Commons
Kento Takaya, Kazuo Kishi

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 1, 2025

ABSTRACT Background Acquired dermal melanocytosis (ADM) is a pigmentary lesion caused by melanocytes in the dermis. These conditions are refractory, and consensus on treatment remains elusive. Aims To compare efficacy of 730‐ 1064‐nm picosecond lasers ADM to supplement comparison with literature review. Patients: We retrospectively examined patients who underwent laser therapy between April 2021 February 2024. Treatments were performed three times spot irradiation using 730‐nm (3‐mm spot, 1.7–1.8 J/cm 2 ; or 2‐mm 2.5–3.25 ) 3.1–4.0 ). Two months after each procedure, patient satisfaction was evaluated questionnaires, macroscopic findings assessed photographs, melanin accumulation analyzed skin analysis software. Evaluations conducted 4‐point scale (excellent, good, fair, poor), good higher considered effective. Results Seventy‐eight 83 assigned groups, respectively. After sessions, group exhibited superior outcomes terms subjective symptoms (patient satisfaction), objective findings, software improvements. The incidence hyperpigmentation 15.4% 14.5% group, no significant differences observed rates other complications. Conclusions use laser, which possesses high selectivity, relatively deep penetration, short pulse width, suggests potentially more effective for ADM, compared effects conventional wavelength, without increasing

Language: Английский

Citations

0
High‐powered 675‐nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders DOI Creative Commons

Massimo DF Vitale,

Francesca Madeddu, Irene Fusco

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(9)

Published: Aug. 29, 2024

Abstract Background Laser technology is a viable therapeutic option for treating number of skin pathologic conditions, including pigmented lesions, vascular lesions and acne scars. Aim In this work, through in vitro clinical investigations we test the efficacy, safety speed treatment high‐powered laser system emitting 675‐nm management various condition. Materials methods experiments were performed irradiating adult human dermal fibroblasts cells (HDFa) with 24, 48 72 h different fluences Ki‐67 + counted. The confocal microscopy images control treated samples acquired. Clinical rejuvenation/diseases treatments 675 nm device parameters 11 patients 5 scars 23 rejuvenation. Data evaluated validated global score using 5‐point scales (GAIS) patient's satisfaction scale. Results application high‐power has proven effective stimulating cell proliferation it led to good results all pathologies. GAIS showed values between 3 4 points pathologies, scores ‘75%‐good improvements’ ‘100%‐excellent improvements’. time was reduced by 50% compared old setting, resulting faster satisfying technique. No serious adverse effects recorded. Conclusion: preclinical data confirm efficacy several

Language: Английский

Citations

2
Picosecond Alexandrite Laser With Diffractive Lens Array Combined With Long‐Pulse Alexandrite Laser for the Treatment of Facial Photoaging in Chinese Women: A Retrospective Study DOI Creative Commons
Changhan Chen,

Youhui Ke

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Facial photoaging is a type of facial skin aging induced mainly by exogenous factors (ultraviolet radiation) and often manifests itself in the form hyperpigmentation, telangiectasia, roughness, increase fine lines/wrinkles, enlarged pores. Recently, picosecond lasers have become an emerging option for treatment photoaging, long-pulse alexandrite (LPAL) demonstrated promising potential photoaging-related symptoms. This study aimed to evaluate efficacy safety laser (PSAL) with diffractive lens array (DLA) combined LPAL photoaging.

Language: Английский

Citations

1
Refractory solar lentigines successfully treated with 532‐nm nanosecond Nd:YAG Vasculature Salvage Laser Surgery (VSLS) system: Case series DOI Creative Commons
So Young Lee,

Ka Ram Kim,

Seunghyeon Kim

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(9)

Published: Sept. 1, 2024

Abstract Background Solar lentigo, a common epidermal hyperpigmented lesion found in sun‐exposed areas, results from the proliferation of melanocytes and accumulation melanin. Although various treatments for solar lentigo have been explored, they often lead to complications, including prolonged erythema post‐inflammatory hyperpigmentation (PIH), posing significant concerns. Objectives methods This study evaluated safety efficacy Vasculature Salvage Laser Surgery (VSLS) system. We treated six Korean patients, each with single session using 532‐nm nanosecond neodymium‐doped yttrium aluminum garnet (Nd:YAG) VSLS system, follow‐up periods ranging 3 10 weeks. Results The treatment led complete removal pigmented lesions all patients without resulting PIH, even cases where previous laser had failed. only side effect observed was mild erythema, which resolved over long term most instances. Conclusions system emerges as safe effective lesions, refractory lentigines. Nonetheless, additional studies are required verify its long‐term efficacy.

Language: Английский

Citations

0
The treatment of melasma with a 785 nm wavelength laser in darker phototypes: An Egyptian experience DOI Creative Commons
Shady M. Ibrahim, Beatrice Marina Pennati,

Riccardo Stocchi

et al.

Skin Research and Technology, Journal Year: 2023, Volume and Issue: 29(12)

Published: Dec. 1, 2023

To the Editor, In women in their 30s/40s with darker phototypes is more common to find melasma. It an acquired hypermelanotic pathology that appears as irregular, light- dark-brown-coloured macules on sun-exposed skin, especially face.1, 2 The most treatments are chemical peels, lasers, topical and oral medications.3 goal of laser therapy target a particular chromophore absorbs laser's wavelength specific manner while minimising collateral tissue damage, according selective photothermolysis theory.4 Specifically, picosecond lasers use pulse lengths much less than target's thermal relaxation period achieve higher peak temperature without inflicting damage surrounding tissues. Because this, 785-nm offers superior safety profile compared other types.5 our experience, 12 Egyptian were treated for facial They presented Fitzpatrick ranging from IV (66.7%) V (33.3%). 27 42 years old. A 785 nm handpiece pumped by QS (El.En Group, Florence, Italy) possibility adding contact sensor was utilised. spot size ranged 6 mm, fluence 0.4–2 J/cm2, frequency 1 5 Hz. Two or three passes made until lesion turned white. Four performed, separated 40/45 days, skin healed completely first treatment. As part home therapy, whitening cream tranexamic acid also applied. Three months after last treatment, final evaluation follow-up visits took place. 5-point (0-4) scale—Global Aesthetic International Score, GAIS (from No change/Worsening Excellent improvement) implied evaluate general area improvement. medical study staff performed assessed 17% patients obtained improvements, 50% Good Moderate 5% Mild improvements results. Moreover, at 3-month (FU) patients' comfort/satisfaction evaluated 5-Point Likert Scale Questionnaire (0 = worse; 4 very satisfied). mean value this data 2.4 ± 1.5. Dermoscopic (DermLite III Pro; 3Gen, CA, USA) baseline 12-week FU detect pigmentation pattern (unpatterned, reticuloglobular, pseudoreticular/arcuate honeycomb, dots/granular) vascular (presence absence telangiectasia) melasma lesion. Some examples cases 3 reported Figures 1-3. whole population confirmed near-complete resolution melasma, no adverse effects conclusion, we proposed time application emitting device treating pigmentary symptoms phototypes. Indeed, it used based its low affinity component so little post-inflammatory effects. This due high melanin characteristic anatomical capillary structure, supporting could lower risk streamline post-treatment maintenance. support findings available request corresponding author. not publicly privacy ethical restrictions.

Language: Английский

Citations

1
Q‐Switched 785 nm laser in the treatment of labial melanotic macules DOI Creative Commons

Giustino Gallo,

Shady M. Ibrahim, Beatrice Marina Pennati

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Jan. 1, 2024

Physiological lip melanosis is a disorder with multifactorial aetiology. It varies ethnicity and typical of people darker skin tones. Benign conditions (ephelides, lentigines, labial melanotic macule), malignant instances (pigmented squamous cell carcinoma, melanoma), drug-induced, post-inflammatory hyperpigmentation (PIH), endocrine disorders, heavy metals, smoking, amalgam tattoo, Laugier-Hunziker syndrome lentiginosis syndromes (Peutz–Jegher's syndrome) are among the factors that can cause pigmentation macules pigmented benign linear increase in pigment basal layer without any melanocyte proliferation vascular component.1 Although treatment not needed, it requested by many patients, who greatly distressed this condition. For melanosis, there is, unfortunately, no effective treatment.2 Patients frequently experiment whitening creams, camouflage lipsticks tattoos getting desired outcome.3 Histological evidence darkening shows abnormal melanin granule aggregation regular number melanocytes an excess dermal melanophages.4 These good targets for Q-switched (QS) lasers because they contain which interested chromophore. This way, collateral tissue damage be reduced. has been demonstrated QS 532-nm laser works perfectly to treat hyperpigmented lips. Nevertheless, negative effects more common, last longer intense than 1064-nm laser.5 The picosecond emit pulses much shorter target's thermal relaxation time so raise peak temperature inflicting on nearby tissues. Given this, study aimed conduct preliminary assessment application 785 nm handpiece (El.En Group, Florence, Italy) hyperpigmentation, minimize blood absorption maximize melanin. A 51-year-old male patient lower subject case study. parameters were spot size 3 mm, fluence 2.8 J/cm2, frequency 2 Hz single pass modality. To get most out technology, contact sensor was included device. follow-up appointments conducted 24 h 14 days following treatment. Our findings indicate patient's mucosa very quickly almost completely recovered, when compared (see Figure 1). Additionally, given visual analogue scale (VAS) range 1 10 value he reported indicated high degree (VAS = 9) satisfaction complete disappearance hyperpigmentation. According Loh et al. (2021), may preferred wavelength treating lesions types. On other hand, 730 emitting devices preferable lightly coefficient at expected 30% higher nm.6 Furthermore, due melanin's over haemoglobin, better 1064 532 targeting or pigment.7 Indeed, we treated different unusual body district such as internal part lip. unique characteristics being component-rich area. Of course, strategies could have used target melanin, 675 532/1064 lasers, previously investigations.8 clinical presented decided conservative approach during treatment, focus component only avoid one. side registered, pain-free bearable patient. Oral healing happens way faster healing. networks related wounds oral regulate inflammatory responses epithelial differentiation.9 In summary, use our warranted improve absorption. confirmed device utilized safety record. nearly elimination ability resume normal activities soon sessions concluded contributed level technology also had benefit having long-term pain.

Language: Английский

Citations

0