Minimizing the Risk of Donor-Derived Events and Maximizing Organ Utilization Through Education and Policy Development

Infectious Disease Clinics of North America, Journal Year: 2023, Volume and Issue: 37(3), P. 443 - 458

Published: June 10, 2023

Language: Английский

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COVID‐19 in organ donors: An organ procurement organization perspective

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(2)

Published: Jan. 8, 2024

Abstract Background The COVID‐19 pandemic presented a significant challenge for Organ Procurement Organizations (OPOs) with the use of SARS‐CoV‐2 positive donors varying widely. This study used detailed single OPO data to determine success using donors. Methods We performed retrospective cohort including all referred Gift Life from January 1, 2021, June 30, 2023. Descriptive analyses were characterize referral and organ utilization. Results There 861 referrals 1 SARS‐Cov‐2 test: 282 ruled out telephone evaluation, 431 onsite evaluation (“evaluated nondonors”) 148 became For who had both nasopharyngeal lower respiratory testing completed, there was notable result discordance observed. Median cycle threshold (Ct) values similar between evaluated nondonors no change in median donor Ct over period. Transplanted organs COVID‐positive included 27 hearts, 88 livers, 5 pancreata, 107 kidneys; lung donation occurred. proportion significantly increased Conclusion large volume demonstrates increasing progressing time, supporting these nonlung transplantation. image

Language: Английский

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Challenging boundaries: Organ transplants from donors with Listeria central nervous system infections

American Journal of Transplantation, Journal Year: 2024, Volume and Issue: 24(7), P. 1289 - 1294

Published: Feb. 29, 2024

Language: Английский

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Pediatric solid organ transplant recipients positive for severe acute respiratory syndrome coronavirus 2 pre‐transplant

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(3)

Published: April 22, 2024

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Should SARS-CoV-2 Vaccination be Required for Heart Transplant Listing

The American Journal of Bioethics, Journal Year: 2024, Volume and Issue: 24(7), P. 117 - 119

Published: June 24, 2024

Language: Английский

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A comprehensive, multifaceted strategy to increase pediatric donor heart utilization

The Journal of Heart and Lung Transplantation, Journal Year: 2024, Volume and Issue: 43(10), P. 1747 - 1755

Published: June 28, 2024

Language: Английский

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Minimizing risk while maximizing opportunity: The infectious disease organ offer process survey

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(5)

Published: July 22, 2024

The purpose of this study was to understand how transplant infectious disease (TID) physicians assess a potential donor with known or suspected infection and describe posttransplant management.

Language: Английский

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Donor‐derived infections in the United States: Opportunities to learn from the Disease Transmission Advisory Committee's experience

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

Abstract The Disease Transmission Advisory Committee (DTAC) of the Organ Procurement and Transplantation Network focuses on issues related to transmission disease through organ transplantation. Providing a review potential cases transmission, translating aggregate data into actionable education guidance for transplant community, providing input policy development, DTAC aims improve safety transplantation reduction in donor‐derived events. Through its nearly 20‐year history, has provided education, guidance, policy, addressed numerous emerging infections, continuously focused community's understanding risk assessment transmission. By updating mission both decrease safely expand donor pool with additional use organs previously not considered due concerns, Committee's role will remain critical.

Language: Английский

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Transplanting COVID-19–Positive Donor Hearts

JACC Heart Failure, Journal Year: 2023, Volume and Issue: 11(4), P. 476 - 477

Published: April 1, 2023

Language: Английский

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Updates in Kidney Transplantation From the 2022 Banff-Canadian Society of Transplantation Joint Meeting: Conference Report

Canadian Journal of Kidney Health and Disease, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

The 2022 Banff-Canadian Society of Transplantation Meeting in Banff, Alberta, brought together transplant professionals to review new developments across various aspects solid organ transplantation (SOT) Canada.Presentations included consensus recommendations from expert-led forums; experiences with procedures and legislation; reports public health data repositories; original clinical laboratory research; industry updates regarding novel technologies. Speakers referenced articles published peer-reviewed journals online, unpublished preliminary findings.All authors attended presentations in-person or virtually. Recordings select were available for later review. Summaries emphasize concepts indicated by speakers as clinically relevant.The COVID-19 pandemic disproportionately affected recipients (SOTRs), who experience worse outcomes infection than the general population. Vaccinations demonstrate an attenuated immunological response SOTRs yet provide meaningful protection. Monoclonal antibodies are effective both passive immunization treatment SOTRs. Infection control protocols have driven development virtual methods research, such using home blood draws follow-up evaluate vaccine efficacy SOTRs; patient care delivery, employing telerehabilitation post transplant. Access living kidney donation is limited disincentives experienced potential donors, which may be overcome more efficient evaluations including a One-Day Living Kidney Donor Assessment Clinic. International Donation Legislative Policy Forum provided means establishing guidance (ODT) program policy standardize delivery jurisdictions. implementation deemed consent model tissue Nova Scotia insight whether this indeed improves access organs. Canada's Indigenous population unique barriers transplantation, prompting efforts inclusive ODT policy-making. Pan-Canadian Data Performance Reporting System Project has defined performance quality indicators, iTransplant other point-of-care software solutions facilitate collection; however, these endeavors ultimately require information technology infrastructure that exceeds capabilities existing Canadian Organ Replacement Register Transplant Registry. Pig-to-human xenotransplantation requires genetic modification pigs xenoantibody testing but prove viable. Serum cell-free DNA, urine biomarkers, markers offer alternative routine biopsy identifying subclinical rejection. Modified perfusion temperatures hydrogen sulfide donor compounds improve preservation. Molecular compatibility tools another improving SOTR outcomes, Genome Canada Consortium been examining important considerations their implementation.We unable capture all topics at meeting due sizable quantity variety. Topics excluded summary include those pathology Banff Classification updates; extra-renal SOT; well numerous abstract poster presentations, allied provider forums, business meetings. A portion material was presented prior peer-review publication.The conference summarized report identify individual clinicians provincial programs access, SOT Canada, while additionally gaps literature investigators encouraged pursue.En 2022, le congrès annuel de la Société canadienne qui s’est tenu à (Alberta) réuni des professionnels se sont penchés sur les nouveaux développements dans divers d’organes solides (TOS) au Canada.Les présentations portaient notamment : recommandations consensuelles issues forums dirigés par experts; l’expérience avec nouvelles procédures et lois; rapports provenant dépôts données santé publique; recherches cliniques laboratoire originales; mises jour du secteur Les intervenants ont fait référence publiés en ligne revues évaluées pairs, ainsi qu’à non publiées conclusions préliminaires.Tous auteurs assisté aux personne ou virtuellement. enregistrements certaines étaient disponibles pour visionnement ultérieur. résumés mettent l’accent jugés comme cliniquement pertinents intervenants.La pandémie affecté receveurs d’une d’organe solide (RTOS) manière disproportionnée; ces derniers ayant suivi une évolution plus défavorable que générale suite COVID-19. La vaccination, bien qu’elle offre protection significative, montre réponse immunologique faible chez RTOS. anticorps monoclonaux efficaces fois l’immunization traitement protocoles contrôle infections mené développement méthodes virtuelles recherche clinique (p. ex. prélèvements sanguins domicile, virtuel évaluer l’efficacité vaccin RTOS) prestation soins patients rééducation distance) après transplantation. L’accès don rein vivant est limité facteurs dissuasifs donneurs potentiels, mais obstacles peuvent être surmontés évaluations efficaces, d’un candidature vivants rein. Le législatif politique international fourni un moyen d’établir lignes directrices dons (DOT), l’objectif normaliser juridiction l’autre. mise œuvre Nouvelle-Écosse consentement présumé tissus pourrait aider déterminer si tel modèle améliore effectivement l’accès organes. populations autochtones confrontées uniques matière ce encourage visant l’élaboration politiques inclusives DOT. Projet système pancanadien mesure DOT défini indicateurs performance, dont d’autres logicielles points soins, faciliter collecte données; nécessitent toutefois informatique dépasse capacités Registre canadien insuffisances transplantations xénogreffe porc humain requiert génétique porcs dépistage xénoanticorps receveurs, elle peut encore s’avérer L’ADN acellulaire sérique, biomarqueurs urinaires marqueurs génétiques offrent biopsie identifier rejets subcliniques. Des températures modifiées contenant composés générateurs sulfure d’hydrogène améliorer conservation outils compatibilité moléculaire autre d’améliorer résultats RTOS, examiné importants prendre considération leur œuvre.Nous n’avons pas été d’assister toutes raison grand nombre grande diversité sujets abordés. exclus résumé incluent pathologie, classification Banff; propres TOS extrarénale; nombreux d’affiches, prestataires alliés réunions d’affaires. Une partie matériel présenté l’a avant l’examen pairs publication.Les résumées présent rapport identifient provinciaux cliniciens pourraient employer l’accès, qualité soulignent lacunes littérature chercheurs encouragés creuser.

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