Variability in exercise tolerance and physiological responses to exercise prescribed relative to physiological thresholds and to maximum oxygen uptake

Experimental Physiology, Journal Year: 2023, Volume and Issue: 108(4), P. 581 - 594

Published: Jan. 29, 2023

Abstract The objective of this study was to determine whether the variability in exercise tolerance and physiological responses is lower when prescribed relative thresholds (THR) compared traditional intensity anchors (TRAD). Ten individuals completed a series maximal tests moderate (MOD), heavy (HVY) severe (HIIT) bouts using THR (critical power gas exchange threshold) TRAD (maximum oxygen uptake; ). There were no differences or acute response between MOD . All HVY but only 30% Compared , where work rates all below critical power, exceeded 70% individuals. was, however, difference HIIT 20% peak ( F = 0.274) average 0.318) blood lactate W′ depletion (the finite capacity above power) after final interval bout 0.305). Using prescribe reduced heterogeneity spanning boundary domains. To increase precision prescription, it recommended that, possible, are used place

Language: Английский

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Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(1), P. 100401 - 100401

Published: Jan. 1, 2025

Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span

Language: Английский

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Physiological significance of elevated levels of lactate by exercise training in the brain and body

Journal of Bioscience and Bioengineering, Journal Year: 2023, Volume and Issue: 135(3), P. 167 - 175

Published: Jan. 20, 2023

Language: Английский

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Understanding the variation in exercise responses to guide personalized physical activity prescriptions

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(4), P. 702 - 724

Published: Jan. 22, 2024

Language: Английский

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Causes and Consequences of Interindividual Response Variability: A Call to Apply a More Rigorous Research Design in Acute Exercise-Cognition Studies

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: July 22, 2021

The different responses of humans to an apparently equivalent stimulus are called interindividual response variability. This phenomenon has gained more and attention in research recent years. field exercise-cognition also taken up this topic, as shown by a growing number studies published the past decade. In perspective article, we aim prompt progress (i) discussing causes consequences variability, (ii) critically examining that have investigated variability neurocognitive outcome parameters acute physical exercises, (iii) providing recommendations for future studies, based on our critical examination. provided recommendations, which advocate rigorous study design, intended help researchers design allowing them draw robust conclusions. This, turn, is very likely foster development practical application findings.

Language: Английский

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Validity of detrended fluctuation analysis of heart rate variability to determine intensity thresholds in elite cyclists

European Journal of Sport Science, Journal Year: 2022, Volume and Issue: 23(4), P. 580 - 587

Published: March 3, 2022

Background: The evaluation of performance in endurance athletes and the subsequent individualisation training is based on determination individual physiological thresholds during incremental tests. Gas exchange or blood lactate analysis are usually implemented for this purpose, but these methodologies expensive invasive. short-term scaling exponent alpha 1 detrended Fluctuation Analysis (DFA-α1) Heart Rate Variability (HRV) has been proposed as a non-invasive methodology to detect intensity thresholds. Purpose: aim study analyse validity DFA-α1 HRV determine elite cyclists compare them against Methodology: 38 male performed graded exercise test their were monitored test. first (LT1 DFA-α1-0.75, HRV, respectively) second (LT2 DFA-α1-0.5, calculated. Then, points matched respective power output (PO) heart rate (HR). Results: There no significant differences (p > 0.05) between DFA-α1-0.75 LT1 with positive correlations PO (r = 0.85) HR 0.66). DFA-α1-0.5 was different LT2 0.04) 0.02), it showed correlation 0.93) 0.71). Conclusions: DFA1-a-0.75 can be used estimate non-invasively cyclists. Further research should explore DFA-α1-0.5.HighlightsThe values derived from threshold high levels agreement when they compared threshold.The < correlation.The fluctuation valid method more studies needed verify its threshold.

Language: Английский

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Evidence-based yet still challenging! Research on physical activity in old age

European Review of Aging and Physical Activity, Journal Year: 2023, Volume and Issue: 20(1)

Published: March 17, 2023

Abstract Preserving functional health and quality-of-life in old age is a major goal global challenge public health. The high rate of sedentary behavior that characteristic the older adult population exacerbates impairments physiological structural systems are typically seen aging process. Achieving an understanding profound influence physical activity on all aspects driving force behind emergence "physical age" as growing area research. Accumulated evidence implies being physically active exercising far superior to other optimal facilitators. Yet this research faces numerous constraints obstacles. This commentary addresses some these challenges, primarily heterogeneity process, which induces both inter- intra-individual differences among aged individuals, assessment tools, unjustified inclusion/exclusion criteria insufficient recruitment strategies, difficulties implementing results real-world conditions, rudimentary exploitation innovative technology. We explain importance establishing network multidisciplinary scientists stakeholders propose consensus-based goals scientifically evidenced wide-ranging plans for dealing with challenges. In addition, we suggest work directions network.

Language: Английский

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Targeting exercise intensity and aerobic training to improve outcomes in Parkinson’s disease

Sport Sciences for Health, Journal Year: 2024, Volume and Issue: 20(2), P. 287 - 297

Published: Feb. 7, 2024

Abstract Aerobic training is popular for people with Parkinson’s disease (PD) given its potential to improve aerobic capacity, relieve symptoms, and stabilise progression. Although current evidence supports some of the assertions surrounding this view, effect exercise intensity on PD currently unclear. Reasons include inconsistent reporting intensity, regimes based general guidelines rather than individualised physiological markers, poor correspondence between intended intensities zones, lack awareness autonomic disturbance in impact outcome. We also consider selective motor function review protocols recent PD, highlighting their limitations. Considering this, we make suggestions a more discerning approach programming.

Language: Английский

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Cardiopulmonary endurance-training responsiveness of metabolic syndrome patients to individualized and standardized exercise prescriptions: a randomized controlled trial

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

This investigation compares the effects of two exercise prescriptions with equal energy consumption but different intensity-determination methods on cardiopulmonary endurance in a population metabolic syndrome (MetS). verified effectiveness individualized patients MetS undergoing moderate-intensity exercises. The participants were randomized into standardized group or group. Exercise intensity was determined based heart rate reserve method and ventilatory threshold model groups completed 12 weeks an prescription frequency consumption. Using testing (CPET), primary secondary cardiovascular indicators measured. percentage change PeakVO2 used to classify as responders non-responders. Other markers auxiliary analysis individual training responses. A total 40 (75% male; mean age: 43.58 ± 11.73; body mass index: 30.39 4.26) all interventions. increased significantly (P < 0.05) both groups. Significant improvements peak maximum voluntary ventilation observed Differences responsiveness also between groups, 70% 90%, respectively, being classified responders, experienced by 14.6% 22.1%, respectively. During period (weeks 4-12), significant difference Similar adverse changes present CPET responders. model-based has advantages population. However, did not reach 100% MetS.

Language: Английский

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Supramaximal interval training using anaerobic speed reserve or sprint interval training in rowers

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Objective This study aimed to compare the consistency of physiological adaptations and inter-individual variability in response three distinct high-intensity interval training (HIIT) protocols—anaerobic power reserve (APR), maximal aerobic (MAP), sprint (SIT)—among elite male rowers. By exploring impact individualized intensity prescriptions, we sought identify most effective protocol for enhancing consistency, as well improving both anaerobic performance while minimizing individual responses. Methods Thirty well-trained rowers (mean age: 24.9 ± 3.1 years; height: 185 4.4 cm; body mass: 86 7.9 kg; fat: 12.5% 2.4%) participated study. All participants were members a national rowing team with an average 6 years competitive experience regular participation international championships. The intervention involved weeks HIIT, performed times per week, pre- post-tests assessing VO 2 max, cardiovascular efficiency (Qmax), (MSP, CP), 2,000-m performance. Results interventions resulted significant improvements Qmax, MSP, time trial (p &lt; 0.05). SIT group exhibited largest relative improvements, max increasing by 6.3% (from 51.9 3.2 55.2 3.3 mL·kg -1 ·min , Cohen’s d = 1.05, 95% CI [0.57, 1.53]), Qmax 6.4% (Cohen’s 1.15, [0.66, 1.64]), 3.7% reduction 0.86, [0.39, 1.33]). Notably, demonstrated lowest across all measured outcomes, evidenced reduced coefficients variation narrower confidence intervals. Conclusion protocol, emphasizing exertion, led consistent greatest key metrics, including These results suggest that may be optimal approach maximizing Future research should explore long-term applicability potential integration other modalities further enhance

Language: Английский

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