Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(1), P. 100401 - 100401

Published: Jan. 1, 2025

Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span

Language: Английский

---

Molecular insights of exercise therapy in disease prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 29, 2024

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for prevention and treatment various diseases, underlying biological mechanisms have not been fully elucidated. Several attributed to signaling molecules that are released in response by different tissues such as skeletal muscle, cardiac adipose, liver tissue. These molecules, which collectively termed exerkines, form a heterogenous group bioactive substances, mediating inter-organ crosstalk well structural functional tissue adaption. Numerous scientific endeavors focused on identifying characterizing new mediators with properties. Additionally, some investigations molecular targets exerkines cellular cascades trigger adaption processes. A detailed understanding tissue-specific downstream effects is crucial harness health-related mediated improve targeted programs health disease. Herein, we review current vivo exerkine-induced signal transduction across multiple target highlight preventive therapeutic value exerkine diseases. By aspects research, provide comprehensive overview (i) underpinnings secretion, (ii) receptor-dependent receptor-independent adaption, (iii) clinical implications these disease treatment.

Language: Английский

---

Effect and optimal exercise prescription of robot-assisted gait training on lower extremity motor function in stroke patients: a network meta-analysis

Neurological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

---

ExerGeneDB: A physical exercise-regulated differential gene expression database

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101027 - 101027

Published: Jan. 1, 2025

Exercise induces molecular changes that involve multiple organs and tissues. Moreover, these are modulated by various exercise parameters-such as intensity, frequency, mode, duration-as well clinical features like gender, age, body mass index (BMI), each eliciting distinct biological effects. To assist researchers in understanding from a comprehensive perspective includes organs, diverse regimens, range of features, we developed Regulated Genes Database (ExerGeneDB), database exercise-regulated differential genes. ExerGeneDB aggregated publicly available exercise-related sequencing datasets subjected them to uniform quality control preprocessing. The data, encompassing variety types, were organized into specialized Notably, conducted analyses on this collected leveraging curated information accounting for important factors such BMI. has assembled 1692 samples rats mice 4492 human samples. It contains data tissues skeletal muscle, blood, adipose tissue, intestine, heart, liver, spleen, lungs, kidneys, brain, spinal cord, bone marrow, bones. bulk Ribonucleic acid (RNA-seq) (including non-coding RNA (ncRNA) protein-coding RNA), microarray ncRNA single cell RNA-seq data. compiles re-analyzes with focus information. This culminated the creation an interactive regulation website can be found at: https://exergenedb.com.

Language: Английский

---

Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Tissue fibrosis represents an aberrant repair process, occurring because of prolonged injury, sustained inflammatory response, or metabolic disorders. It is characterized by excessive accumulation extracellular matrix (ECM), resulting in tissue hardening, structural remodeling, and loss function. This pathological phenomenon a common feature the end stage numerous chronic diseases. Despite advent novel therapeutic modalities, including antifibrotic agents, these have only modest efficacy reversing established are associated with adverse effects. In recent years, growing body research has demonstrated that exercise significant benefits potential treatment fibrosis. The anti-fibrotic effects mediated multiple mechanisms, direct inhibition fibroblast activation, reduction expression pro-fibrotic factors such as transforming growth factor-β (TGF-β) slowing collagen deposition. Furthermore, been to assist maintaining dynamic equilibrium repair, thereby indirectly reducing damage can also help maintain balance improving disorders, exerting anti-inflammatory antioxidant effects, regulating cellular autophagy, restoring mitochondrial function, activating stem cell activity, apoptosis, alleviating tissue. paper presents review its underlying mechanisms for range fibrosis, cardiac, pulmonary, renal, hepatic, skeletal muscle. offers valuable reference point non-pharmacological intervention strategies comprehensive fibrotic

Language: Английский

---

Towards optimizing exercise prescription for type 2 diabetes: modulating exercise parameters to strategically improve glucose control

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 71 - 88

Published: March 22, 2024

Abstract Type 2 diabetes (T2D) is a complex and multifaceted condition clinically characterized by high blood glucose. The management of T2D requires holistic approach, typically involving combination pharmacological interventions as well lifestyle changes, such incorporating regular exercise, within an overall patient-centred approach. However, several condition-specific contextual factors can modulate the glucoregulatory response to acute or chronic exercise. In era precision medicine, optimizing exercise prescription in effort maximize glucose lowering effects holds promise for reducing risk complications improving quality life individuals living with this condition. Reflecting on main pathophysiological features T2D, we review evidence highlight how related be modulated target improved control including frequency, intensity, total volume, timing (e.g., pre- vs. post-prandial) modality aerobic resistance training). We also propose step-by-step, general framework clinicians practitioners personalize optimize glycemic T2D.

Language: Английский

---

Effects of weight loss on testosterone, sex hormone‐binding globulin, adiposity, and insulin sensitivity in women and men

Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Testosterone and glucose disposal (Rd) are positively associated in adult men, whereas the opposite is reported women. Sex-specific relationships between testosterone or sex hormone-binding globulin (SHBG) Rd men women with without obesity following weight loss were examined. Adult (n = 27/28; BMI 20-41 kg/m2) underwent measurements of body composition, Rd, SHBG, bioavailable (BioA) total testosterone. Men 17/15) completed a 16-week dietary weight-loss program repeat testing. BioA was lower related to negatively (p < 0.05). Across participants, increased SHBG 0.01). unchanged men; however, individual changes independently 0.031). In women, declined 0.009) but not Rd. Weight reduced women; improved men. better correlate Additional studies should identify mechanisms that drive differences interventions modify testosterone, reduce adiposity, improve across both sexes.

Language: Английский

---

Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 637 - 637

Published: April 18, 2025

Physical activity (PA) and body composition are important lifestyle factors that influence public health. Research suggests DNA regions (CpG site locations) differentially methylated in a physically active population. This meta-analysis aimed to identify CpG sites associated with various levels of PA metabolic pathways. The followed PRISMA guidelines using PubMed, SportDISCUS, Embase, Scopus, Cochrane Web Science. Epigenomic analyses performed on participants no underlying health conditions were included. Articles screened Rayyan AI extracted sites, their location confirmed the EWAS catalogue. Six studies comprising 770 subjects included this meta-analysis. was clinical metrics from six showed BMI, blood pressure, insulin glucose testing significantly improved upon intervention. Amongst studies, total 257 participants, 134 CpGs located 92 genes obesity-related identified either belonged lipid metabolism or signalling pathway. which regulated multiple tissue types JAZF1 (insulin signalling, carbohydrate pathways) NAV1 (mTOR pathway). In conclusion, current epigenomic induce differential methylation signatures affect metabolism. To understand positive molecular effects PA, further research above candidate needs be conducted amongst

Language: Английский

---

Movement analysis in the diagnosis and management of Parkinson’s disease

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(2), P. 485 - 486

Published: May 10, 2024

Burtscher, Johannes; Bourdillon, Nicolas; Janssen Daalen, Jules M.; Patoz, Aurélien; Bally, Julien F.; Kopp, Martin; Malatesta, Davide; Bloem, Bastiaan R. Author Information

Language: Английский

---

Beyond FITT

Published: May 21, 2024

Research on physical activity and health, including planned structured forms such as acute chronic exercise, has focused understanding potential dose-response relationships.Traditionally, the variables of (i) Frequency, (ii) Intensity, (iii) Time, (iv) Type (known FITT principle) have been used to operationalize dose activity.In this article, we describe limitations propose that it should be complemented by underappreciated variable density, which defines temporal distribution stimuli within a single bout or between successive bouts relative time spent resting (e.g., in napping/sleeping sedentary behaviors).Using field brain health an example, discuss challenges opportunities for further research use density improve our doseresponse relationships health-related outcomes.

Language: Английский

---