Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: June 6, 2017

The association of irregular sleep schedules with circadian timing and academic performance has not been systematically examined. We studied 61 undergraduates for 30 days using diaries, quantified regularity a novel metric, the index (SRI). In most least regular quintiles, phase light exposure were assessed salivary dim-light melatonin onset (DLMO) wrist-worn photometry, respectively. DLMO occurred later (00:08 ± 1:54 vs. 21:32 1:48; p < 0.003); daily propensity rhythm peaked (06:33 0:19 04:45 0:11; 0.005); rhythms had lower amplitude (102 19 lux 179 29 lux; 0.005) in Irregular compared to Regular sleepers. A mathematical model pacemaker its response was used demonstrate that group differences likely primarily due their different patterns exposure. positive correlation (r = 0.37; 0.004) between SRI observed. These findings show college students are associated delayed performance. Moreover, modeling results reveal light-based interventions may be therapeutically effective improving this population.

Language: Английский

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Effects of light on human circadian rhythms, sleep and mood

Somnologie - Schlafforschung und Schlafmedizin, Journal Year: 2019, Volume and Issue: 23(3), P. 147 - 156

Published: Aug. 20, 2019

Humans live in a 24-hour environment, which light and darkness follow diurnal pattern. Our circadian pacemaker, the suprachiasmatic nuclei (SCN) hypothalamus, is entrained to solar day via pathway from retina synchronises our internal biological rhythms. Rhythmic variations ambient illumination impact behaviours such as rest during sleep activity wakefulness well their underlying processes. Rather recently, availability of artificial has substantially changed especially evening night hours. This may increase risk developing rhythm sleep-wake disorders (CRSWD), are often caused by misalignment endogenous rhythms external light-dark cycles. While exact relationship between CRSWD remains be established, nocturnal been shown alter humans. On other hand, can also used an effective noninvasive therapeutic option with little no side effects, improve sleep,mood general well-being. article reviews current state knowledge regarding effects on rhythms, sleep, mood.

Language: Английский

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Effects of artificial light at night on human health: A literature review of observational and experimental studies applied to exposure assessment

Chronobiology International, Journal Year: 2015, Volume and Issue: 32(9), P. 1294 - 1310

Published: Sept. 16, 2015

It has frequently been reported that exposure to artificial light at night (ALAN) may cause negative health effects, such as breast cancer, circadian phase disruption and sleep disorders. Here, we reviewed the literature assessing effects of human ALAN in order list various aspects ALAN. Several electronic databases were searched for articles, published through August 2014, related on health; these also included details experiments exposure. A total 85 articles review. observational studies showed outdoor levels are a risk factor cancer indoor intensity individual lighting habits relevant this risk. Exposure bright during nighttime suppresses melatonin secretion, increases onset latency (SOL) alertness. Circadian misalignment caused by chronic have psychological, cardiovascular and/or metabolic functions. causes disruption, which with longer duration later evening. shorter wavelengths preferentially disturb secretion shifts, even if is not bright. This review be helpful understand suggests it necessary consider characteristics light, beyond mere intensity.

Language: Английский

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Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015

Journal of Clinical Sleep Medicine, Journal Year: 2015, Volume and Issue: 11(10), P. 1199 - 1236

Published: Oct. 14, 2015

A systematic literature review and meta-analyses (where appropriate) were performed the GRADE approach was used to update previous American Academy of Sleep Medicine Practice Parameters on treatment intrinsic circadian rhythm sleep-wake disorders.Available data allowed for positive endorsement (at a second-tier degree confi dence) strategically timed melatonin (for DSWPD, blind adults with N24SWD, children/ adolescents ISWRD comorbid neurological disorders), light therapy or without accompanying behavioral interventions (adults ASWPD, children/adolescents elderly dementia).Recommendations against use discrete sleep-promoting medications are provided demented patients, at second-and fi rst-tier dence, respectively.No recommendations remaining treatments/ populations, due either insuffi cient absent data.Areas where further research is needed discussed.

Language: Английский

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Circadian system, sleep and endocrinology

Molecular and Cellular Endocrinology, Journal Year: 2011, Volume and Issue: 349(1), P. 91 - 104

Published: Sept. 11, 2011

Language: Английский

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Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption

The Science of The Total Environment, Journal Year: 2017, Volume and Issue: 607-608, P. 1073 - 1084

Published: July 27, 2017

Language: Английский

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Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001571 - e3001571

Published: March 17, 2022

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way quantifying influence intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate effects. The report recommendations lighting, based an expert scientific consensus expressed easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. are supported by detailed analysis sensitivity circadian, neuroendocrine, alerting responses ocular provide straightforward framework inform design practice.

Language: Английский

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Breast cancer and circadian disruption from electric lighting in the modern world

CA A Cancer Journal for Clinicians, Journal Year: 2013, Volume and Issue: 64(3), P. 207 - 218

Published: Dec. 24, 2013

Abstract Breast cancer is the leading cause of death among women worldwide, and there only a limited explanation why. Risk highest in most industrialized countries but also rising rapidly developing world. Known risk factors account for portion incidence high‐risk populations, has been considerable speculation many false leads on other possibly major determinants risk, such as dietary fat. A hallmark industrialization increasing use electricity to light night, both within home without. It recently become clear that this evolutionarily new and, thereby, unnatural exposure can disrupt human circadian rhythmicity, which three salient features are melatonin production, sleep, clock. convergence research cells, rodents, humans suggests health consequences disruption may be substantial. An innovative experimental model shown at night markedly increases growth breast xenografts rats. In humans, theory specific predictions being tested epidemiologically: evidence accumulated shift workers, blind women, impact sleep duration risk. If electric does explain burden, then practical interventions implemented, including more selective adoption recent advances lighting technology application. CA Cancer J Clin 2014;64:207–218. © 2013 American Society.

Language: Английский

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Human responses to bright light of different durations

The Journal of Physiology, Journal Year: 2012, Volume and Issue: 590(13), P. 3103 - 3112

Published: April 24, 2012

Light exposure in the early night induces phase delays of circadian rhythm melatonin humans. Previous studies have investigated effect timing, intensity, wavelength, history and pattern light stimuli on human timing system. We present results from a study duration–response relationship to phase-delaying bright light. Thirty-nine young healthy participants (16 female; 22.18±3.62 years) completed 9-day inpatient study. Following three baseline days, underwent an initial assessment procedure dim (<3 lux), were then randomized for pulse (∼10,000 lux) 0.2 h, 1.0 2.5 h or 4.0 duration during 4.5 controlled-posture episode centred 16 wake episode. After another 8 sleep episode, second assessment. Phase shifts calculated difference clock time onset (DLMO) between final assessments. Exposure varying durations reset pacemaker dose-dependent, non-linear manner. Per minute exposure, was over 5 times more effective at delaying (1.07±0.36 h) as compared with (2.65±0.24 h). Acute suppression subjective sleepiness also had dose-dependent response duration. These provide strong evidence resetting

Language: Английский

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Circadian behavior is light-reprogrammed by plastic DNA methylation

Nature Neuroscience, Journal Year: 2014, Volume and Issue: 17(3), P. 377 - 382

Published: Feb. 16, 2014

Language: Английский

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