Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response DOI Open Access

Viera Šebenová Jerigová,

Michal Zeman, Monika Okuliarová

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 13722 - 13722

Published: Nov. 8, 2022

Circadian rhythms control almost all aspects of physiology and behavior, allowing temporal synchrony these processes between each other, as well with the external environment. In immune system, daily leukocyte functions can determine strength response, thereby regulating efficiency defense mechanisms to cope infections or tissue injury. The natural light/dark cycle is prominent synchronizing agent perceived by circadian clock, but this role light highly compromised irregular working schedules unintentional exposure artificial at night (ALAN). primary concern disrupted important physiological processes, underlying potential links adverse health effects. Here, we first discuss consequences genetic disruption induced mutation deletion specific clock genes. Next, evaluate experimental research into effects disruptive regimes, particularly light-phase shifts, dim ALAN, constant on innate under steady state acute inflammation, in pathogenesis common lifestyle diseases. We suggest that a better understanding which influences status be importance search for strategies minimize negative chronodisruption health.

Language: Английский

Mechanisms of blue light-induced eye hazard and protective measures: a review DOI Creative Commons
Xinli Ouyang, Jing Yang,

Zexin Hong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 130, P. 110577 - 110577

Published: Aug. 4, 2020

The risk of blue light exposure to human health has attracted increased research attention. Blue light, with relatively high energy, can cause irreversible photochemical damage eye tissue. Excessive the tends a series alterations, such as oxidative stress, mitochondrial apoptosis, inflammatory apoptosis and DNA damage, resulting in development dry disease, glaucoma, keratitis. Accordingly, physical protection, chemical pharmaceutical protective measures, gene therapy, other methods are widely used clinical treatment hazard. We reviewed studies on possible light-induced signaling pathways mechanisms summarized therapeutic approaches addressing

Language: Английский

Citations

163
Sleeping when the world locks down: Correlates of sleep health during the COVID-19 pandemic across 59 countries DOI Creative Commons
Dilara Yüksel, Grace B. McKee, Paul B. Perrin

et al.

Sleep Health, Journal Year: 2021, Volume and Issue: 7(2), P. 134 - 142

Published: Jan. 26, 2021

Language: Английский

Citations

133
The influence of the environment and lifestyle on myopia DOI Creative Commons
Sayantan Biswas,

Antonio El Kareh,

Mariyem Qureshi

et al.

Journal of PHYSIOLOGICAL ANTHROPOLOGY, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 31, 2024

Abstract Background Myopia, commonly known as near-sightedness, has emerged a global epidemic, impacting almost one in three individuals across the world. The increasing prevalence of myopia during early childhood heightened risk developing high and related sight-threatening eye conditions adulthood. This surge rates, occurring within relatively stable genetic framework, underscores profound influence environmental lifestyle factors on this condition. In comprehensive narrative review, we shed light both established potential contributors that affect development progression myopia. Main body Epidemiological interventional research consistently revealed compelling connection between increased outdoor time decreased children. protective effect may primarily be attributed to exposure characteristics natural (i.e., sunlight) release retinal dopamine. Conversely, irrespective time, excessive engagement near work can further worsen onset While exact mechanisms behind exacerbation are not fully comprehended, it appears involve shifts relative peripheral refraction, overstimulation accommodation, or complex interplay these factors, leading issues like image defocus, blur, chromatic aberration. Other spatial frequency visual environment, circadian rhythm, sleep, nutrition, smoking, socio-economic status, education have debatable independent influences development. Conclusion environment exerts significant Improving modifiable key predictors spent outdoors prevent slow intricate connections often obscure findings, making challenging disentangle their individual effects. complexity necessity for prospective studies employ objective assessments, such quantifying work, among others. These crucial gaining more understanding how various modified

Language: Английский

Citations

57
Sleep Deprivation and Insomnia in Adolescence: Implications for Mental Health DOI Creative Commons
Sarà Uccella, Ramona Cordani, Federico Salfi

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(4), P. 569 - 569

Published: March 28, 2023

Sleep changes significantly throughout the human lifespan. Physiological modifications in sleep regulation, common with many mammals (especially circadian rhythms), predispose adolescents to loss until early adulthood. Adolescents are one-sixth of all beings and at high risk for mental diseases (particularly mood disorders) self-injury. This has been attributed incredible number occurring a limited time window that encompasses rapid biological psychosocial modifications, which teens at-risk behaviors. Adolescents’ patterns have investigated as biunivocal cause potential damaging conditions, insufficient may be both consequence health problems. The recent COVID-19 pandemic particular made detrimental contribution adolescents’ quality. In this review, we aim summarize knowledge field explore implications (and future adults’) physical health, well outline strategies prevention.

Language: Английский

Citations

50
Wearables in Chronomedicine and Interpretation of Circadian Health DOI Creative Commons
Denis Gubin,

Dietmar Weinert,

Oliver Stefani

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 327 - 327

Published: Jan. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Language: Английский

Citations

2
The Brain’s Reward System in Health and Disease DOI
Robert G. Lewis,

Ermanno Florio,

Daniela Punzo

et al.

Advances in experimental medicine and biology, Journal Year: 2021, Volume and Issue: unknown, P. 57 - 69

Published: Jan. 1, 2021

Language: Английский

Citations

88
The effects of seasons and weather on sleep patterns measured through longitudinal multimodal sensing DOI Creative Commons
Stephen M. Mattingly, Ted Grover, Gonzalo J. Martinez

et al.

npj Digital Medicine, Journal Year: 2021, Volume and Issue: 4(1)

Published: April 28, 2021

Abstract Previous studies of seasonal effects on sleep have yielded unclear results, likely due to methodological differences and limitations in data size and/or quality. We measured the habits 216 individuals across U.S. over four seasons for slightly a year using objective, continuous, unobtrusive measures local weather. In addition, we controlled demographics trait-like constructs previously identified correlate with behavior. investigated weather duration, bedtime, wake time. found several small but statistically significant patterns. observe strongest time especially during spring season: times are earlier, duration decreases (compared reference season winter). Sleep also modestly when day lengths get longer (between winter summer solstice). Bedtimes tend be later as outdoor temperature increases.

Language: Английский

Citations

79
The circadian clock and metabolic homeostasis: entangled networks DOI Creative Commons
Leonardo Vinícius Monteiro de Assis, Henrik Oster

Cellular and Molecular Life Sciences, Journal Year: 2021, Volume and Issue: 78(10), P. 4563 - 4587

Published: March 8, 2021

Abstract The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. synchrony between daily challenges imposed by environment needs to be aligned with biological processes and internal clock. In this review, is provided in-depth view molecular functioning clock, how system organized, central peripheral clocks communicate each other. sense, we provide overview neuro-hormonal factors controlled they affect tissues. We also evaluate signals released organs their effects other brain areas. Additionally, possible communication tissues novel layer organization reviewing recent studies literature. last section, analyze can modulate intracellular tissue-dependent metabolic organs. Taken altogether, goal review integrative function emphasis

Language: Английский

Citations

62
Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression DOI Open Access
Dmytro I. Boiko, Anastasiia D. Shkodina, Mohammad Mehedi Hasan

et al.

Neurochemical Research, Journal Year: 2022, Volume and Issue: 47(10), P. 2909 - 2924

Published: June 11, 2022

Language: Английский

Citations

43
A review of the current state of research on artificial blue light safety as it applies to digital devices DOI Creative Commons
Nikita Wong, Hamed Bahmani

Heliyon, Journal Year: 2022, Volume and Issue: 8(8), P. e10282 - e10282

Published: Aug. 1, 2022

Light is necessary for human health and well-being. As we spend more time indoors, are being increasingly exposed to artificial light. The development of lighting has allowed us control the brightness, colour, timing our light exposure. Yet, widespread use raised concerns about impact altering environment on health. adoption personal digital devices over past decade yet another source We a significant amount using with light-emitting screens, including smartphones tablets, at close range. emitted from these devices, while appearing white, an emission spectrum peak in blue Blue often characterised as hazardous its photon energy higher than that other wavelengths visible Under certain conditions, can cause harm retina ocular structures. also influence circadian rhythm processes mediated by melanopsin-expressing intrinsically photosensitive retinal ganglion cells. While component sunlight various physiological processes, whether low-illuminance presents risk remains ongoing area debate. technological advancements continue, it relevant understand how new may This review examines existing research safety eye, visual performance, functions.

Language: Английский

Citations

43