CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture DOI Creative Commons
David Forsberg,

Zachi Horn,

Evangelia Tserga

et al.

eLife, Journal Year: 2016, Volume and Issue: 5

Published: June 27, 2016

Inflammation-induced release of prostaglandin E2 (PGE2) changes breathing patterns and the response to CO2 levels. This may have fatal consequences in newborn babies result sudden infant death. To elucidate underlying mechanisms, we present a novel brainstem organotypic culture that generates rhythmic neural network motor activity for 3 weeks. We show increased elicits gap junction-dependent PGE2. alters preBötzinger rhythm-generating complex chemosensitive respiratory regions, thereby increasing sigh frequency depth inspiration. used mice lacking eicosanoid prostanoid receptors (EP3R), slices optogenetic inhibition EP3R+/+ cells demonstrate EP3R is important ventilatory hypercapnia. Our study identifies pathway linking inflammatory systems, with implications inspiration sighs throughout life, ability autoresuscitate when fails.

Language: Английский

Breathing matters DOI
Christopher A. Del Negro, Gregory D. Funk, Jack L. Feldman

et al.

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(6), P. 351 - 367

Published: May 8, 2018

Language: Английский

Citations

569
Neural Control of Breathing and CO2 Homeostasis DOI Creative Commons

Patrice G. Guyenet,

Douglas A. Bayliss

Neuron, Journal Year: 2015, Volume and Issue: 87(5), P. 946 - 961

Published: Sept. 1, 2015

Language: Английский

Citations

408
Descending Command Neurons in the Brainstem that Halt Locomotion DOI Creative Commons
Julien Bouvier, Vittorio Caggiano, Roberto Leiras

et al.

Cell, Journal Year: 2015, Volume and Issue: 163(5), P. 1191 - 1203

Published: Nov. 1, 2015

Language: Английский

Citations

242
Neural circuits of social behaviors: Innate yet flexible DOI Creative Commons

Dongyu Wei,

Vaishali Talwar,

Dayu Lin

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(10), P. 1600 - 1620

Published: March 11, 2021

Language: Английский

Citations

142
Breathing Rhythm and Pattern and Their Influence on Emotion DOI Open Access
Sufyan Ashhad, Kaiwen Kam, Christopher A. Del Negro

et al.

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 223 - 247

Published: March 9, 2022

Breathing is a vital rhythmic motor behavior with surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies complex neural control system, central pattern generator (bCPG), that exhibits diverse operational modes to regulate gas exchange coordinate an array behaviors. In this review, we focus selected advances in our understanding bCPG. At core bCPG preBötzinger (preBötC), which drives inspiratory rhythm via unexpectedly sophisticated emergent mechanism. Synchronization dynamics underlying preBötC rhythmogenesis imbue system robustness lability. These are modulated by inputs from throughout generate rhythmic, patterned activity widely distributed. connectivity emerging literature support link between breathing, emotion, cognition becoming experimentally tractable. bring great potential for elucidating function dysfunction other mammalian circuits.

Language: Английский

Citations

88
Efferent projections of excitatory and inhibitory preBötzinger Complex neurons DOI
Cindy F. Yang, Jack L. Feldman

The Journal of Comparative Neurology, Journal Year: 2018, Volume and Issue: 526(8), P. 1389 - 1402

Published: Feb. 23, 2018

The preBötzinger Complex (preBötC), a compact medullary region essential for generating normal breathing rhythm and pattern, is the kernel of central pattern generator (CPG). Excitatory preBötC neurons in rats project to major breathing-related brainstem regions. Here, we provide connectivity map mice both excitatory inhibitory neurons. Using genetic strategy label neurons, confirmed extensive projections within CPG including contralateral preBötC, Bötzinger (BötC), ventral respiratory group, nucleus solitary tract, parahypoglossal nucleus, parafacial (RTN/pFRG or alternatively, pFL /pFV ), parabrachial Kölliker-Füse nuclei, as well midbrain periaqueductal gray. Interestingly, paralleled projections. Moreover, examined overlapping pons detail found that they targeted same We further explored direct anatomical link between suprapontine brain regions may govern emotion other complex behaviors can affect be affected by breathing. Forebrain efferent were sparse restricted specific nuclei thalamus hypothalamus, with processes rarely observed cortex, basal ganglia, limbic regions, e.g., amygdala hippocampus. conclude sends direct, presumably inspiratory-modulated, parallel distinct targets throughout generate modulate and/or coordinate behaviors, physiology, cognition, emotional state.

Language: Английский

Citations

162
Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo DOI Creative Commons
Yan Cui, Kaiwen Kam, David Sherman

et al.

Neuron, Journal Year: 2016, Volume and Issue: 91(3), P. 602 - 614

Published: Aug. 1, 2016

Language: Английский

Citations

156
The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time DOI
Jan‐Marino Ramirez, Nathan A. Baertsch

Annual Review of Neuroscience, Journal Year: 2018, Volume and Issue: 41(1), P. 475 - 499

Published: May 1, 2018

Rhythmicity is a universal timing mechanism in the brain, and rhythmogenic mechanisms are generally dynamic. This illustrated for neuronal control of breathing, behavior that occurs as one-, two-, or three-phase rhythm. Each breath assembled stochastically, increasing evidence suggests each phase can be generated independently by dedicated excitatory microcircuit. Within microcircuit, rhythmicity emerges through three entangled mechanisms: ( a) glutamatergic transmission, which amplified b) intrinsic bursting opposed c) concurrent inhibition. triangle dynamically tuned neuromodulators other network interactions. The ability coupled oscillators to reconfigure recombine may allow breathing remain robust yet plastic enough conform nonventilatory behaviors such vocalization, swallowing, coughing. Lessons learned from respiratory translate highly dynamic integrated rhythmic systems, if approached one at time.

Language: Английский

Citations

103
Proton detection and breathing regulation by the retrotrapezoid nucleus DOI Open Access
Patrice G. Guyenet, Douglas A. Bayliss, Ruth L. Stornetta

et al.

The Journal of Physiology, Journal Year: 2016, Volume and Issue: 594(6), P. 1529 - 1551

Published: Jan. 10, 2016

Abstract We discuss recent evidence which suggests that the principal central respiratory chemoreceptors are located within retrotrapezoid nucleus (RTN) and RTN neurons directly sensitive to [H + ]. glutamatergic. In vitro , their activation by ] requires expression of a proton‐activated G protein‐coupled receptor (GPR4) proton‐modulated potassium channel (TASK‐2) whose transcripts undetectable in astrocytes rest lower brainstem network. The pH response is modulated surrounding but genetic deletion or both GPR4 TASK‐2 virtually eliminates chemoreflex. Thus, although this reflex regulated innumerable brain pathways, it seems operate predominantly modulating discharge rate neurons, hypercapnia may ultimately derive from intrinsic sensitivity. increase lung ventilation stimulating multiple aspects breathing simultaneously. They stimulate about equally during quiet wake non‐rapid eye movement (REM) sleep, lesser degree REM sleep. activity inhibitory feedback excitatory inputs, notably carotid bodies. latter input operates normo‐ fails activate under hypocapnic conditions. inhibition probably limits hyperventilation produced hypoxia. also activated inputs serotonergic hypothalamic neurons. absence underlies sleep apnoea lack chemoreflex characterize congenital hypoventilation syndrome. image

Language: Английский

Citations

95
Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences DOI

Inge Steuer,

Pierre A. Guertin

Reviews in the Neurosciences, Journal Year: 2018, Volume and Issue: 30(2), P. 107 - 164

Published: Dec. 13, 2018

Central pattern generators (CPGs) are generally defined as networks of neurons capable enabling the production central commands, specifically controlling stereotyped, rhythmic motor behaviors. Several CPGs localized in brainstem and spinal cord areas have been shown to underlie expression complex behaviors such deglutition, mastication, respiration, defecation, micturition, ejaculation, locomotion. Their pivotal roles clearly demonstrated although their organization cellular properties remain incompletely characterized. In recent years, insightful findings about made mainly because (1) several complementary animal models were developed; (2) these enabled a wide variety techniques be used and, hence, plethora characteristics discovered; (3) organizations, functions, cell across all species studied thus far found well-preserved phylogenetically. This article aims at providing an overview for non-experts most important on vivo models, vitro preparations from invertebrate vertebrate well primates. Data CPG adaptation, organization, will summarized with special attention paid network locomotion given its advanced level characterization compared some other CPGs. Similarities differences between also highlighted.

Language: Английский

Citations

89