Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 6, 2023

Abstract Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005–0.02 Hz), neurogenic (N; 0.02–0.04 and myogenic (M; 0.04–0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive PFC. Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Language: Английский

Pass‐Transistor Logic Circuits Based on Wafer‐Scale 2D Semiconductors DOI
Xinyu Wang, Xinyu Chen, Jingyi Ma

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(48)

Published: June 21, 2022

2D semiconductors, such as molybdenum disulfide (MoS2 ), have attracted tremendous attention in constructing advanced monolithic integrated circuits (ICs) for future flexible and energy-efficient electronics. However, the development of large-scale ICs based on materials is still its early stage, mainly due to non-uniformity individual devices little investigation device circuit-level optimization. Herein, a 4-inch high-quality monolayer MoS2 film successfully synthesized, which then used fabricate top-gated (TG) field-effect transistors with wafer-scale uniformity. Some basic static random access memory ring oscillators are examined. A pass-transistor logic configuration pseudo-NMOS employed design more complex circuits, fabricated proper functions tested. These preliminary integration efforts show promising potential semiconductors application ICs.

Language: Английский

Citations

34
Functional Near-Infrared Spectroscopy as a Personalized Digital Healthcare Tool for Brain Monitoring DOI Creative Commons
Zephaniah Phillips, Raymart Jay Canoy, Seung-ho Paik

et al.

Journal of Clinical Neurology, Journal Year: 2023, Volume and Issue: 19(2), P. 115 - 115

Published: Jan. 1, 2023

The sustained growth of digital healthcare in the field neurology relies on portable and cost-effective brain monitoring tools that can accurately monitor function real time. Functional near-infrared spectroscopy (fNIRS) is one such tool has become popular among researchers clinicians as a practical alternative to functional magnetic resonance imaging, complementary modalities electroencephalography. This review covers contribution fNIRS personalized goals by identifying two major trends drive current research. first trend multimodal using fNIRS, which allows access more data will help them understand interconnection between cerebral hemodynamics other physiological phenomena patients. make an overall assessment physical health obtain more-detailed individualized diagnosis. second research being conducted with naturalistic experimental paradigms involve multisensory stimulation familiar settings. Cerebral during dynamic activities or within virtual reality helps complex occur everyday life. Finally, scope future studies discussed facilitate more-accurate assessments activation wider clinical acceptance medical device for healthcare.

Language: Английский

Citations

14
Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 3, 2024

Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005-0.02 Hz), neurogenic (N; 0.02-0.04 and myogenic (M; 0.04-0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive (PFC). Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Language: Английский

Citations

4
Monitoring nap deprivation-induced fatigue using fNIRS and deep learning DOI
Pei Ma,

Chenyang Pan,

Huijuan Shen

et al.

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 23, 2025

Language: Английский

Citations

0
Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near‐infrared spectroscopy: A scoping review DOI Creative Commons
Owais A. Khan, Simin Rahman, Kanishka Baduni

et al.

Developmental Medicine & Child Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Aim To map and critically appraise the literature on feasibility current use of functional near‐infrared spectroscopy (fNIRS) to assess cortical activity, connectivity, neuroplasticity in individuals with cerebral palsy (CP). Method A scoping review methodology was prospectively registered reported following Preferred Reporting Items for Systematic Meta‐Analysis Extension Scoping Reviews (PRISMA‐ScR) guidelines. systematic search conducted four databases. Empirical studies using fNIRS neural or CP aged 3 years older were included. Results Sixteen met inclusion criteria. Individuals (age range = 3–43 years; 70% unilateral CP) underwent fNIRS‐based assessment task‐evoked activity (studies [ n ] 15) and/or resting‐state connectivity ( 3). Preliminary observations suggest greater magnitude, extent, ipsilateral hemispheric lateralization sensorimotor cortex CP, while magnitude patterns prefrontal appear dependent task demands. Normalization metrics observed postintervention 3) paralleled improvements outcomes, highlighting their potential as promising biomarkers gains CP. Interpretation This details highlights research gaps technical limitations, offers recommendations support implementation ecologically valid neuroimaging

Language: Английский

Citations

0
The neural characteristics influencing literacy outcome in children with cochlear implants DOI Creative Commons
Nabin Koirala,

Jacy Manning,

Sara Neumann

et al.

Brain Communications, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 1, 2025

Early hearing intervention in children with congenital loss is critical for improving auditory development, speech recognition and both expressive receptive language, which translates into better educational outcomes quality of life. In receiving aids or cochlear implants, adaptive potentially maladaptive neural reorganization can mitigate higher-level functions that impact reading. The focus the present study was to dissect underpinnings reading networks implants assess how these mediate ability implants. Cortical activity obtained using naturalistic stimuli from 75 (50 implant recipients, aged 7-17, 25 age-matched typical hearing) functional near-infrared spectroscopy. Assessment basic skill completed Reading Inventory Scholastic Evaluation. We computed directed connectivity haemodynamic reading-associated anterior posterior brain regions time-frequency causality estimation method known as temporal partial coherence. influence implant-related clinical measures on outcome extent mediated effects were examined structural equation modelling. Our findings reveal timing (e.g. age first aid) significantly influenced their ability. Furthermore, reading-related processes (word decoding, vocabulary, morphology sentence processing) substantially by within circuits. Notably, differed across various skills. Hearing age, defined at a participant received adequate access sound, initial implantation emerged robust predictors proficiency. current one identify characteristics emphasize importance duration deafness early enhancing strengthening network connections. However, evidence further suggested such positive influences cannot fully offset detrimental deprivation. Consequently, additional, perhaps more specialized, interventions might be necessary maximize benefits prosthetic intervention.

Language: Английский

Citations

0
Enhancement of Frequency-Specific Hemodynamic Power and Functional Connectivity by Transcranial Photobiomodulation in Healthy Humans DOI Creative Commons
Nghi Cong Dung Truong, Xinlong Wang, Hashini Wanniarachchi

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 10, 2022

Transcranial photobiomodulation (tPBM) has been considered a safe and effective brain stimulation modality being able to enhance cerebral oxygenation neurocognitive function. To better understand the underlying neurophysiological effects of tPBM in human brain, we utilized 111-channel functional near infrared spectroscopy (fNIRS) system map hemodynamic responses over whole head 8-min with 1,064-nm laser given on forehead 19 healthy participants. Instead analyzing broad-frequency signals (0-0.2 Hz), investigated frequency-specific three infra-slow oscillation (ISO) components consisting endogenic, neurogenic, myogenic vasomotions. Significant changes induced by spectral power oxygenated hemoglobin concentration (Δ[HbO]), connectivity (FC), global network metrics at each ISO frequency bands were identified mapped topographically for comparisons. Our novel findings revealed that significantly increased endogenic Δ[HbO] powers right frontopolar area site. Also, demonstrated enabled significant enhancements FC across cortical regions as well several metrics. These consistent recent reports met expectation is highly associated endothelial activity, which stimulated tPBM-evoked nitric oxide (NO) release.

Language: Английский

Citations

15
Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults DOI Creative Commons
Sadra Shahdadian, Xinlong Wang,

Shu Kang

et al.

Neurophotonics, Journal Year: 2023, Volume and Issue: 10(02)

Published: June 5, 2023

Transcranial photobiomodulation (tPBM) is a noninvasive neuromodulation method that facilitates the improvement of human cognition. However, limited information available in literature on wavelength- and site-specific effects prefrontal tPBM. Moreover, 2-channel broadband near-infrared spectroscopy (2-bbNIRS) new approach for quantifying infra-slow oscillations (ISO; 0.005 to 0.2 Hz) neurophysiological networks resting brain vivo.We aim prove hypothesis hemodynamic metabolic activities cortex are significantly modulated by tPBM modulation different ISO bands.Noninvasive 8-min with an 800- or 850-nm laser sham was delivered either side forehead 26 healthy young adults. A 2-bbNIRS unit used record activity 7 min before after tPBM/sham. The measured time series were analyzed frequency domain determine coherence at each three bands. Sham-controlled values represent tPBM-induced networks.Prefrontal wavelength lateral (1) increased ipsilateral metabolic-hemodynamic coupling endogenic band (2) desynchronized bilateral metabolism neurogenic vascular smooth-muscle hemodynamics myogenic band. Site-specific also observed significant enhancement connectivity right 800-nm tPBM.Prefrontal can modulate bilaterally unilaterally cortex. Such site- wavelength-specific

Language: Английский

Citations

7
Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study DOI
Sadra Shahdadian, Xinlong Wang,

Shu Kang

et al.

Cerebral Cortex Communications, Journal Year: 2022, Volume and Issue: 3(3)

Published: July 1, 2022

Abstract The resting-state infraslow oscillation (ISO) of the cerebral cortex reflects neurophysiological state human brain. ISO results from distinct vasomotion with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. Quantification prefrontal in cortical hemodynamics metabolism resting brain may facilitate identification objective features that are characteristic certain disorders. goal this study was to explore quantify concentration changes oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics all 3 E/N/M Two-channel broadband near-infrared spectroscopy (2-bbNIRS) enabled measurements forehead 26 healthy young participants a once week for 5 weeks. After quantifying spectral amplitude (SA) coherence at each band, several key statistically reliable were obtained features: (i) SA Δ[HbO] bands, (ii) Δ[CCO] M (iii) bilateral connectivity across E N (iv) unilateral hemodynamic–metabolic coupling These have promising potential be developed biomarkers clinical applications future.

Language: Английский

Citations

11
Functional near-infrared spectroscopy imaging of the prefrontal cortex during a naturalistic comedy movie DOI Creative Commons

Noam Somech,

Tamar Mizrahi,

Yael Caspi

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 8, 2022

Naturalistic stimulation (i.e., movies and auditory narratives of some minutes’ length) has been a powerful approach to bringing more real-life experiences into laboratory experiments. Data-driven, intersubject correlation (ISC) analysis permits examining what extent activity in specific brain region correlates across participants during exposure naturalistic stimulus, as well testing whether neural with behavioral measures. Notably, most the previous research stimuli was conducted using functional fMRI (fMRI). Here, we tested ISC are feasible near-infrared spectroscopy (fNIRS) - imaging method particularly suited for populations patients children. Fifty-three healthy adult watched twice 3-min segment Charlie Chaplin movie while recorded on surface their prefrontal cortex fNIRS. In addition, an independent group 18 used continuous scoring procedure rate which they felt that different parts fragment were funny. Our two findings follows. First, found higher-than-zero fNIRS signals lobes, result high oxygenated channels first repetition movie. Second, significant negative between ratings movie’s humorousness. series control analyses demonstrated this latter could not be explained by various non-humor-related sensory properties (e.g., volume image brightness). The key overall outcome present study is combination paradigms might sensitive explore cognitive processing. results also suggest potential role humor appreciation.

Language: Английский

Citations

8