Effects of COVID-19 on the Nervous System

Cell, Journal Year: 2020, Volume and Issue: 183(1), P. 16 - 27.e1

Published: Aug. 19, 2020

Language: Английский

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The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 24(3), P. 368 - 378

Published: Dec. 16, 2020

Language: Английский

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Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(12), P. 4407 - 4407

Published: June 21, 2020

Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about passage. Here, we used multiple-time regression analysis to examine ability of 10 exosome populations derived from mouse, human, cancerous, and non-cancerous cell lines BBB. All crossed BBB, rates varied over 10-fold. Lipopolysaccharide (LPS), an activator innate immune system, enhanced uptake independently BBB disruption for six exosomes decreased one. Wheatgerm agglutinin (WGA) modulated transport five populations, suggesting passage by adsorptive transcytosis. Mannose 6-phosphate inhibited J774A.1, demonstrating that its transporter mannose receptor. Uptake rates, patterns, effects LPS or WGA were not predicted source (mouse vs. human) cancer status lines. The surface proteins CD46, AVβ6, AVβ3, ICAM-1 variably expressed predictive rate nor responses WGA. A brain-to-blood efflux mechanism affected CNS retention explains how CNS-derived enter blood. In summary, all tested here readily at varying a variety vesicular-mediated mechanisms involving specific transporters, transcytosis, system.

Language: Английский

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Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies

International Journal of Biological Macromolecules, Journal Year: 2019, Volume and Issue: 151, P. 1012 - 1029

Published: Nov. 9, 2019

Language: Английский

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Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Immunity & Ageing, Journal Year: 2020, Volume and Issue: 17(1)

Published: Jan. 20, 2020

Abstract Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides same coin, resulting in immune disorder. Immunosenescence refers to disruption structural architecture organs dysfunction responses, from both aged innate adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, mainly attributed somatic cellular senescence-associated secretory phenotype (SASP) age-related autoimmune predisposition. However, inability reduce senescent cells (SSCs), because immunosenescence, exacerbates inflammaging. Age-related deviations, particularly altered T cell function, are derived thymic atrophy or involution, hallmark aging. Recently, there have been major developments understanding how involution contributes at molecular levels, including genetic epigenetic regulation, well many potential rejuvenation strategies. Herein, we discuss research progress uncovering inflammaging, their intersection. We also describe immunity mediates plays crucial role progression neurological cardiovascular diseases, cancer. then briefly outline underlying mechanisms finally summarize strategies restore function.

Language: Английский

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Macrophages at CNS interfaces: ontogeny and function in health and disease

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(9), P. 547 - 562

Published: July 29, 2019

Language: Английский

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Blood-Brain Delivery Methods Using Nanotechnology

Pharmaceutics, Journal Year: 2018, Volume and Issue: 10(4), P. 269 - 269

Published: Dec. 11, 2018

Pathologies of the brain, which brain cancer, Alzheimer's disease, Parkinson's stroke, and multiple sclerosis, are some most prevalent, that presently poorly treated due to difficulties associated with drug development, administration, targeting brain. The existence blood-brain barrier, a selective permeability system acts as local gateway against circulating foreign substances, represents key challenge for delivery therapeutic agents However, development nanotechnology-based approaches delivery, such nanoparticles, liposomes, dendrimers, micelles, carbon nanotubes, might be solution improved therapies.

Language: Английский

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Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

ACS Nano, Journal Year: 2020, Volume and Issue: 14(9), P. 11452 - 11462

Published: Aug. 21, 2020

Nature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. The "Terminator" the science fiction film cybernetic organism with living tissue over metal endoskeleton, which us to develop natural-killer-cell-mimic aggregation-induced emission (AIE) characteristics (NK@AIEdots) by coating natural kill cell membrane on an AIE-active polymeric PBPTV, highly bright NIR-II conjugated polymer. Owing AIE soft-matter of as-prepared NK@AIEdots maintained superior brightness (quantum yield ∼7.9% water) good biocompatibility. Besides, they can serve as tight junction (TJ) modulator trigger intracellular signaling cascade, causing TJ disruption actin cytoskeleton reorganization form intercellular "green channel" help them cross blood–brain barrier (BBB) silently. Furthermore, initiatively accumulate glioblastoma cells complex brain matrix for high-contrast through-skull tumor imaging. growth was also greatly inhibited these under NIR light illumination. As far we know, quantum PBPTV highest among existing luminescent polymers. NK-cell biomimetic showed great potential BBB-crossing active delivery.

Language: Английский

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Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: June 4, 2019

The blood-brain barrier (BBB) mediates the communication between periphery and central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This stimulated wealth of information on molecular impact brain, particularly improvement cognition. Since BBB regulates transport into brain thus, helps regulate levels, alterations response could resistance. In this review, we summarize effect some cell types that make up BBB, including endothelial cells, neurons, astrocytes, pericytes. We broadly discuss how these changes specific ultimately BBB. also can levels pathological hallmarks Alzheimer's disease, amyloid beta (Aβ) tau within each type. Finally, suggest interventional approaches overcome detrimental effects regards transport.

Language: Английский

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Healthy aging and the blood–brain barrier

Nature Aging, Journal Year: 2021, Volume and Issue: 1(3), P. 243 - 254

Published: March 15, 2021

Language: Английский

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