Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 214, P. 107620 - 107620
Published: June 26, 2020
Language: Английский
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: June 7, 2021
Metformin is one of the most widely prescribed hypoglycemic drugs and has potential to treat many diseases. More more evidence shows that metformin can regulate function macrophages in atherosclerosis, including reducing differentiation monocytes inhibiting inflammation, oxidative stress, polarization, foam cell formation apoptosis macrophages. The mechanisms by which regulates include AMPK, AMPK independent targets, NF-κB, ABCG5/8, Sirt1, FOXO1/FABP4 HMGB1. On basis summarizing these studies, we further discussed future research directions metformin: single-cell RNA sequencing, neutrophil extracellular traps (NETs), epigenetic modification, metformin-based combination drugs. In short, play an important role a variety diseases, improving macrophage dysfunction may be mechanism for expand its pleiotropic pharmacological profile. addition, with other improve (such as SGLT2 inhibitors, statins IL-1β inhibitors/monoclonal antibodies) enhance therapeutic conditions such obesity, cancer, dementia aging.
Language: Английский
Citations
93
Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 68(24), P. 6464 - 6484
Published: May 22, 2020
Chlorogenic acids (CGAs) have gained considerable attention as pervasive human dietary constituents with potential cardiovascular-preserving effects. The main sources include coffee, yerba mate, Eucommia ulmodies leaves, and Lonicerae Japonicae Flos. CGA consumption can reduce the risks of hypertension, atherosclerosis, heart failure, myocardial infarction, other factors associated cardiovascular risk, such obesity type 2 diabetes. This review recapitulates recent advances CGAs in effects, pharmacokinetics, sources, safety. Emerging evidence indicates that exhibit circulatory guarding properties through suppression oxidative stress, leukocyte infiltration, platelet aggregation, platelet-leukocyte interactions, vascular remodeling, apoptosis well regulation glucose lipid metabolism vasodilatory action system. exert these effects by acting on complex signaling networks, but global mechanisms are still not clear. oral bioavailability is poor, there a sensitization concern about CGA. bioactive metabolites, systematic toxicity, optimized structure needed for further identification.
Language: Английский
Citations
91
Current Atherosclerosis Reports, Journal Year: 2020, Volume and Issue: 22(10)
Published: Aug. 9, 2020
Language: Английский
Citations
83
Food & Function, Journal Year: 2021, Volume and Issue: 12(24), P. 12194 - 12220
Published: Jan. 1, 2021
Cardiovascular diseases (CVDs) and diabetes are the leading causes of death worldwide, which underlines urgent necessity to develop new pharmacotherapies. Cinnamon has been an eminent component spice traditional Chinese medicine for thousands years. Numerous lines findings have elucidated that cinnamon beneficial effects against CVDs in various ways, including endothelium protection, regulation immune response, lowering blood lipids, antioxidative properties, anti-inflammatory suppression vascular smooth muscle cell (VSMC) growth mobilization, repression platelet activity thrombosis inhibition angiogenesis. Furthermore, emerging evidence established improves diabetes, a crucial risk factor CVDs, by enhancing insulin sensitivity secretion; regulating enzyme involved glucose; glucose metabolism liver, adipose tissue muscle; ameliorating oxidative stress inflammation protect islet cells; improving complications. In this review, we summarized mechanisms regulates order provide theoretical basis further clinical application cinnamon.
Language: Английский
Citations
74
Cardiovascular Research, Journal Year: 2021, Volume and Issue: 118(3), P. 716 - 731
Published: Jan. 13, 2021
The prothrombotic state in atrial fibrillation (AF) occurs as a result of multifaceted interactions, known Virchow's triad hypercoagulability, structural abnormalities, and blood stasis. More recently, there is emerging evidence that lipoproteins are implicated this process, beyond their traditional role atherosclerosis. In review, we provide an overview the various explore association between AF, effects on haemostasis, potential contribution to thrombogenesis AF. There several types based size, lipid composition, apolipoprotein category, namely: chylomicrons, very low-density lipoprotein, lipoprotein (LDL), intermediate-density high-density lipoprotein. Each these may contain numerous species proteins with variety different functions. Furthermore, particles be oxidized causing alteration structure content. Of note, paradoxical inverse relationship total cholesterol LDL (LDL-C) levels, incident mechanism by which related stabilizing effect myocardial membranes, along its inflammation. Overall, specific interact haemostatic pathways promote excess platelet activation thrombin generation, well inhibiting fibrinolysis. regard, LDL-C has been shown independent risk factor for thromboembolic events complex lipoproteins, thrombosis AF warrants further research aim improve our knowledge base contribute overall understanding lipoprotein-mediated thrombosis.
Language: Английский
Citations
73
Theranostics, Journal Year: 2021, Volume and Issue: 11(19), P. 9376 - 9396
Published: Jan. 1, 2021
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates glucose levels and positively affects cardiovascular function in patients with diabetes complications. Endothelial dysfunction (ED) represents primary pathological change of multiple vascular diseases, because it causes decreased arterial plasticity, increased resistance, reduced tissue perfusion atherosclerosis. Caused by "biochemical injury", ED is also an independent predictor events. Accumulating evidence shows that metformin improves through liver kinase B1 (LKB1)/5'-adenosine monophosphat-activated protein (AMPK) AMPK-independent targets, including nuclear factor-kappa B (NF-κB), phosphatidylinositol 3 kinase-protein (PI3K-Akt), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), forkhead box O1 (FOXO1), krüppel-like factor 4 (KLF4) 2 (KLF2). Evaluating effects on cell functions would facilitate our understanding therapeutic potential diabetology (including its complications). This article reviews physiological cells intact endothelium, latest research related complications, focuses mechanism action regulating functions.
Language: Английский
Citations
66
Pharmacological Research, Journal Year: 2021, Volume and Issue: 169, P. 105639 - 105639
Published: April 28, 2021
Language: Английский
Citations
57
Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(8), P. 2157 - 2175
Published: Sept. 13, 2022
Natural products possess pleiotropic cardiovascular protective effects owing to their anti-oxidation, anti-inflammation and anti-thrombotic properties. Kaempferol, (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), is a kind of naturally occurring flavonoid existing in many common fruits vegetables (e.g., onions, broccoli, strawberries grapes) particularly traditional Chinese medicine as exemplified by Ginkgo biloba. Epidemiological, preclinical clinical studies have revealed an inverse association between the consumption kaempferol-containing foods medicines risk developing diseases. Numerous translational experimental animal models cultured cells demonstrated wide range pharmacological activities kaempferol. In this article, we reviewed antioxidant, anti-inflammatory cardio-protective kaempferol elucidated potential molecular basis therapeutic capacity focusing on its anti-atherosclerotic effects. Overall, review presents health benefits plants reflects possible drug candidate prevent treat atherosclerosis, underlying pathology most
Language: Английский
Citations
48
Phytomedicine, Journal Year: 2022, Volume and Issue: 108, P. 154520 - 154520
Published: Oct. 22, 2022
The development of digital technologies and the evolution open innovation approaches have enabled creation diverse virtual organizations enterprises coordinating their activities primarily online. platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together collaborative environment individuals interested natural product scientific research, empower interactions by using communication tools.In this work, we present a general overview INPST showcase specific use Twitter as powerful networking tool that used host one-week "2021 Networking Event" (spanning from 31st May 2021 6th June 2021) based on application hashtag #INPST.The during event period analyzed with Symplur Signals (https://www.symplur.com/), revealing total 6,036 tweets, shared 686 users, which generated 65,004,773 impressions (views respective tweets). This event's achieved high visibility participation rate showcases convincing example how social media can be highly effective Twitter-based international biomedical research events.
Language: Английский
Citations
46
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9
Published: Jan. 20, 2022
Ferroptosis is a new form of regulatory cell death characterized by iron-dependent and intracellular lipid peroxidation. can be divided into two stages. The first stage iron overload in the cell, which generates large amount reactive oxygen species through Fenton reaction, second results from an imbalance antioxidant system. Excessive phospholipid hydroperoxides cannot removed reduction reactions, as this could destroy membrane structure interfere with mitochondrial function, eventually leading to ferroptosis cell. Cardiovascular diseases have gradually become cause modern society. relationship between occurrence progression cardiovascular disease has research hotspot recent years. In review, we summarize mechanism its specific role disease.
Language: Английский
Citations
42