Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic Targets

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8162 - 8162

Published: May 3, 2023

We are witnessing the globalization of a specific type arteriosclerosis with rising prevalence, incidence and an overall cardiovascular disease burden. Currently, atherosclerosis increasingly affects younger generation as compared to previous decades. While early preventive medicine has seen improvements, research advances in laboratory clinical investigation promise provide us novel diagnosis tools. Given physio-pathological complexity epigenetic patterns discovery new molecules involved, therapeutic field room for substantial growth. Thus, scientific community is currently investigating role nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, crucial component innate immune system different inflammatory disorders. NLRP3 activated by distinct factors numerous cellular molecular events which trigger inflammasome assembly subsequent cleavage pro-interleukin (IL)-1β pro-IL-18 pathways via caspase-1 activation, eliciting endothelial dysfunction, promotion oxidative stress inflammation process atherosclerosis. In this review, we introduce basic mechanisms activation its also emphasize promising pharmaceutical potential.

Language: Английский

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MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR−/− mice

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155489 - 155489

Published: March 11, 2024

Language: Английский

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Targeted Delivery of Mesenchymal Stem Cell-Derived Bioinspired Exosome-Mimetic Nanovesicles with Platelet Membrane Fusion for Atherosclerotic Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2553 - 2571

Published: March 1, 2024

Purpose: Accumulating evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes hold significant potential for the treatment of atherosclerosis. However, large-scale production and organ-specific targeting are still challenges further clinical applications. This study aims to explore targeted efficiency therapeutic biomimetic platelet membrane-coated exosome-mimetic nanovesicles (P-ENVs) in Methods: To produce (ENVs), MSCs were successively extruded through polycarbonate porous membranes. P-ENVs engineered by fusing MSC-derived ENVs with membranes characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blot. The stability safety also assessed. efficacy was evaluated an vivo imaging system (IVIS) spectrum immunofluorescence. Histological analyses, Oil Red O (ORO) staining, blot used investigate anti-atherosclerotic effectiveness P-ENVs. Results: Both exhibited similar characteristics exosomes. Subsequent miRNA sequencing revealed their mitigate atherosclerosis influencing biological processes related cholesterol metabolism. In ApoE −/− mice model, intravenous administration enhanced atherosclerotic plaques, resulting a reduction lipid deposition necrotic core area. Our vitro experiments showed promoted efflux reduced total content foam cells. Further attenuated intracellular accumulation upregulating expression critical transporters ABCA1 ABCG1. Conclusion: highlighted as novel nano-drug delivery platform enhancing drug while concurrently mitigating adverse reactions therapy. Keywords: nanovesicles, biomimicry, delivery,

Language: Английский

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Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 2, 2024

Abstract Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis treatment atherosclerosis (AS) are crucial for reducing occurrence acute events. However, AS is challenging, oral anti‐AS drugs suffer from limitations like imprecise targeting low bioavailability. To overcome aforementioned shortcomings, Cur/MOF@DS developed, a nanoplatform integrating by loading curcumin (Cur) into metal−organic frameworks with nanozymes magnetic resonance imaging (MRI) properties. In addition, surface‐modification dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within plaque region. This employs mechanisms that scavenge excessive reactive oxygen species microenvironment, promote macrophage autophagy regulate polarization to realize lipid regulation. vivo vitro experiments confirm this outstanding MRI performance effects, which may provide new option AS.

Language: Английский

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Cyclodextrins: Potential therapeutics against atherosclerosis

Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 214, P. 107620 - 107620

Published: June 26, 2020

Language: Английский

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