The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association

Stroke, Journal Year: 2023, Volume and Issue: 54(6)

Published: April 3, 2023

Preservation of brain health has emerged as a leading public priority for the aging world population. Advances in neurovascular biology have revealed an intricate relationship among cells, meninges, and hematic lymphatic vasculature (the neurovasculome) that is highly relevant to maintenance cognitive function. In this scientific statement, multidisciplinary team experts examines these advances, assesses their relevance disease, identifies knowledge gaps, provides future directions.

Language: Английский

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Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

Nature, Journal Year: 2024, Volume and Issue: 627(8002), P. 157 - 164

Published: Feb. 28, 2024

Language: Английский

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Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

Nature, Journal Year: 2023, Volume and Issue: 623(7989), P. 992 - 1000

Published: Nov. 15, 2023

Language: Английский

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Brain clearance is reduced during sleep and anesthesia

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(6), P. 1046 - 1050

Published: May 13, 2024

It has been suggested that the function of sleep is to actively clear metabolites and toxins from brain. Enhanced clearance also said occur during anesthesia. Here, we measure movement fluorescent molecules in brains male mice show is, fact, independent wake or Moreover, brain markedly reduced, not increased,

Language: Английский

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Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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