Apigenin Alleviates Obesity-Associated Metabolic Syndrome by Regulating the Composition of the Gut Microbiome DOI Creative Commons
Yuan Qiao, Zhichun Zhang, Yuanyuan Zhai

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 3, 2022

The gut microbiota, often viewed as a "digestive organ," can influence the development of obesity and related metabolic disorders. Diet is significantly important in shaping structure modulating function microbiota. Apigenin (Api) widely exists fruits vegetables naturally occurring flavonoid has anti-obesogenic, anti-inflammatory, anti-carcinogenic properties. Its low bioavailability means it enough time to interact with intestine thus becomes potential substrate for intestine; thus, contributing health. Here, we show that Api reduces whole-body weight, low-grade inflammation, insulin resistance high-fat diet (HFD)-induced obese mice. Our results reflect supplementation substantially improve intestinal dysbiosis triggered by HFD restores barrier damage alleviating endotoxemia. Augmentation Akkermansia Incertae_Sedis along reduction Faecalibaculum Dubosiella at genus level potentially mediated protective effects on syndrome. Furthermore, impact body weight modification microbiota could be transferred from Api-administered mice HFD-feeding via horizontal fecal transplantation. Taken together, our data highlight prebiotic role its contribution restraint deterioration associated

Language: Английский

The biological fate and bioefficacy of citrus flavonoids: bioavailability, biotransformation, and delivery systems DOI
Man Zhang, Siyue Zhu,

Wenjian Yang

et al.

Food & Function, Journal Year: 2021, Volume and Issue: 12(8), P. 3307 - 3323

Published: Jan. 1, 2021

This article discusses the biological fate and bioefficacy of citrus flavonoids by emphasizing on their bioavailability, biotransformation delivery systems.

Language: Английский

Citations

78
In vitro and in vivo inhibitory effect of anthocyanin-rich bilberry extract on α-glucosidase and α-amylase DOI

Yanglin Ji,

Dong Liu,

Yan Jin

et al.

LWT, Journal Year: 2021, Volume and Issue: 145, P. 111484 - 111484

Published: April 21, 2021

Language: Английский

Citations

72
Polysaccharide from Agrocybe cylindracea prevents diet-induced obesity through inhibiting inflammation mediated by gut microbiota and associated metabolites DOI
Zhenjun Zhu, Rui Huang,

Aohuan Huang

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 209, P. 1430 - 1438

Published: April 21, 2022

Language: Английский

Citations

64
Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production DOI Creative Commons
Yuta Sugiyama,

Yumiko Mori,

Misaki Nara

et al.

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: Oct. 10, 2022

Colonic luminal aromatic amines have been historically considered to be derived from dietary source, especially fermented foods; however, recent studies indicate that the gut microbiota serves as an alternative source of these amines. Herein, we show five prominent genera Firmicutes (Blautia, Clostridium, Enterococcus, Ruminococcus, and Tyzzerella) ability abundantly produce through action amino acid decarboxylase (AADC). In vitro cultivation human fecal samples revealed a significant positive correlation between aadc copy number Ruminococcus gnavus phenylethylamine (PEA) production. Furthermore, using genetically engineered Enterococcus faecalis-colonized BALB/cCrSlc mouse model, showed bacterial stimulates production colonic serotonin, which is reportedly involved in osteoporosis irritable bowel syndrome. Finally, AADC inhibitors carbidopa benserazide inhibit PEA En. faecalis.

Language: Английский

Citations

52
Apigenin Alleviates Obesity-Associated Metabolic Syndrome by Regulating the Composition of the Gut Microbiome DOI Creative Commons
Yuan Qiao, Zhichun Zhang, Yuanyuan Zhai

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 3, 2022

The gut microbiota, often viewed as a "digestive organ," can influence the development of obesity and related metabolic disorders. Diet is significantly important in shaping structure modulating function microbiota. Apigenin (Api) widely exists fruits vegetables naturally occurring flavonoid has anti-obesogenic, anti-inflammatory, anti-carcinogenic properties. Its low bioavailability means it enough time to interact with intestine thus becomes potential substrate for intestine; thus, contributing health. Here, we show that Api reduces whole-body weight, low-grade inflammation, insulin resistance high-fat diet (HFD)-induced obese mice. Our results reflect supplementation substantially improve intestinal dysbiosis triggered by HFD restores barrier damage alleviating endotoxemia. Augmentation Akkermansia Incertae_Sedis along reduction Faecalibaculum Dubosiella at genus level potentially mediated protective effects on syndrome. Furthermore, impact body weight modification microbiota could be transferred from Api-administered mice HFD-feeding via horizontal fecal transplantation. Taken together, our data highlight prebiotic role its contribution restraint deterioration associated

Language: Английский

Citations

48