Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154979 - 154979

Published: July 18, 2023

Language: Английский

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Probiotic fermentation of polyphenols: potential sources of novel functional foods

Food Production Processing and Nutrition, Journal Year: 2022, Volume and Issue: 4(1)

Published: Sept. 5, 2022

Abstract Fermented functional food products are among the major segments of processing industry. Fermentation imparts several characteristic effects on foods including enhancement organoleptic characteristics, increased shelf-life, and production novel health beneficial compounds. However, in addition to macronutrients present food, secondary metabolites such as polyphenols also emerging suitable fermentable substrates. Despite traditional antimicrobial view polyphenols, accumulating research shows that exert differential bacterial communities by suppressing growth pathogenic microbes while concomitantly promoting proliferation survival probiotic bacteria. Conversely, bacteria not only survive but induce their fermentation which often leads improved bioavailability metabolic intermediates, polyphenolic content, thus enhanced capacity fermented food. In addition, selective combinations polyphenol-rich or fortification with can result foods. The narrative review specifically explores potential substrates We discuss bidirectional relationship between an aim at development based amalgamation polyphenols. Graphical abstract

Language: Английский

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Protective Roles of Apigenin Against Cardiometabolic Diseases: A Systematic Review

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: April 15, 2022

Apigenin is a flavonoid with antioxidant, anti-inflammatory, and anti-apoptotic activity. In this study, the potential effects of apigenin on cardiometabolic diseases were investigated in vivo vitro . Potential signaling networks different cell types induced by identified, suggesting that molecular mechanisms vary types. Additionally, apigenin-induced biological response analyzed, including obesity, diabetes, hypertension cardiovascular diseases. This review provides novel insights into role

Language: Английский

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Bio-Actives from Natural Products with Potential Cardioprotective Properties: Isolation, Identification, and Pharmacological Actions of Apigenin, Quercetin, and Silibinin

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2387 - 2387

Published: March 5, 2023

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. As a result, pharmaceutical non-pharmaceutical interventions modifying risk factors for CVDs top priority scientific research. Non-pharmaceutical therapeutical approaches, including herbal supplements, have gained growing interest from researchers as part therapeutic strategies primary or secondary prevention CVDs. Several experimental studies supported potential effects apigenin, quercetin, silibinin beneficial supplements in cohorts at Accordingly, this comprehensive review focused critically on cardioprotective effects/mechanisms abovementioned three bio-active compounds natural products. For purpose, we included vitro, preclinical, clinical associated with atherosclerosis wide variety cardiovascular (hypertension, diabetes, dyslipidemia, obesity, cardiac injury, metabolic syndrome). In addition, attempted to summarize categorize laboratory methods their isolation identification plant extracts. This unveiled many uncertainties which still unexplored, such extrapolation results practice, mainly due small studies, heterogeneous doses, divergent constituents, absence pharmacodynamic/pharmacokinetic analyses.

Language: Английский

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Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 31, 2024

Obesity is a major risk factor for morbidity and mortality because it has close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, some types of cancer. With no drugs available, the mainstay obesity management remains lifestyle changes with exercise dietary modifications. In light tremendous disease burden unmet therapeutics, fresh perspectives on pathophysiology drug discovery are needed. The development epigenetics provides compelling justification how environmental, lifestyle, other factors contribute pathogenesis obesity. Furthermore, epigenetic dysregulations can be restored, been reported that certain natural products obtained from plants, tea polyphenols, ellagic acid, urolithins, curcumin, genistein, isothiocyanates, citrus isoflavonoids, were shown inhibit weight gain. These substances have great antioxidant potential interest they also modify mechanisms. Therefore, understanding modifications target primary cause mechanisms anti-obesity effects phytochemicals prove rational strategies prevent develop novel therapeutic interventions. Thus, current review aimed summarize advances in therapies based provide evidence several targets.

Language: Английский

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Apigenin remodels the gut microbiota to ameliorate ulcerative colitis

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 16, 2022

Introduction Ulcerative colitis (UC), a chronic non-specific colorectal inflammatory disease with unclear etiology, has long plagued human health. Gut microbiota dysbiosis destroy homeostasis of the colon, which is closely related to ulcerative progress. Apigenin, flavonoid widely present in celery, been found improve colitis. However, potential molecular mechanism apigenin ameliorating through protecting intestinal barrier and regulating gut remains undefined. Methods Dextran sodium sulfate (DSS)-induced mouse model was conducted evaluate effect on UC. Disease activity index score mice, colon tissue pathological, cytokines analysis, tight junction proteins expression, colonic content short-chain fatty acids (SCFAs) 16S rRNA gene sequencing were reflect protection Results The results indicated that significantly relieved pathological injury, increased goblet cells quantity mucin secretion, promoted anti-inflammatory IL-10 inhibited expression proinflammatory cytokines, TNF-α, IL-1β, IL-6 MPO tissue. Apigenin ZO-1, claudin-1 occludin expressions restore integrity barrier. Moreover, remodeled disordered by abundance Akkermansia , Turicibacter Klebsiella Romboutsia etc., its metabolites (SCFAs), attenuating DSS-induced injury. We also investigated supplementation metabolic pathways microbiota. Conclusion effectively ameliorated UC via balancing microbiome inhibit inflammation protect With low toxicity high efficiency, might serve as therapeutic strategy for treatment interaction between host microorganism.

Language: Английский

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Capsaicin Ameliorates High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice via Remodeling Gut Microbiota

Nutrients, Journal Year: 2022, Volume and Issue: 14(20), P. 4334 - 4334

Published: Oct. 17, 2022

Capsaicin is a pungent alkaloid abundantly present in peppers with outstanding biological activities, including the anti-atherosclerosis effect. Previous studies revealed that gut microbiota played an important role beneficial effects of capsaicin, but whether it essential for effect capsaicin unclear. This study evaluated ApoE-/- mice and further explored depleting improvement atherosclerosis. The results showed administration could prevent development atherosclerosis improve serum lipids inflammation, while antibiotic intervention abolished alleviation by capsaicin. In addition, significantly increase abundance Turicibacter, Odoribacter, Ileibacterium feces, decrease deoxycholic acid, cholic hypoxanthine, stercobilin cecal content. Our provides evidence plays critical

Language: Английский

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Sulforaphane Ameliorates Nonalcoholic Fatty Liver Disease Induced by High-Fat and High-Fructose Diet via LPS/TLR4 in the Gut–Liver Axis

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 743 - 743

Published: Feb. 1, 2023

The gut–liver axis has emerged as a key player in the progression of non-alcoholic fatty liver disease (NAFLD). Sulforaphane (SFN) is bioactive compound found cruciferous vegetables; however, it not been reported whether SFN improves NAFLD via axis. C57BL/6 mice were fed high-fat and high-fructose (HFHFr) diet, with or without gavage at doses 15 30 mg·kg−1 body weight for 12 weeks. results showed that reduced gain, hepatic inflammation, steatosis HFHFr mice. altered composition gut microbes. Moreover, enhanced intestinal tight junction protein ZO-1, serum LPS, inhibited LPS/TLR4 ERS pathways to reduce inflammation. As result, protected integrity declined gut-derived LPS translocations diet-induced decreased levels pathway activations, thus inhibiting pro-inflammatory cytokines. Notably, Spearman correlation analysis protective effect on barrier its anti-inflammatory was associated improved dysbiosis. Above all, dietary intervention attenuates through

Language: Английский

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Gut bacterial markers involved in association of dietary inflammatory index with visceral adiposity

Nutrition, Journal Year: 2024, Volume and Issue: 122, P. 112371 - 112371

Published: Jan. 30, 2024

Language: Английский

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Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic Traits of Akkermansia muciniphila: From Mouse to Man

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 45 - 45

Published: Dec. 20, 2022

Akkermansia muciniphila is a mucosal symbiont considered gut microbial marker in healthy individuals, as its relative abundance significantly reduced subjects with inflammation and metabolic disturbances. Dietary polyphenols can distinctly stimulate the of A. muciniphila, contributing to attenuation several diseases, including obesity, type 2 diabetes, inflammatory bowel liver damage. However, mechanistic insight into how or activity limited. This review focuses on dietary interventions rodents humans vitro studies using different phenolic classes. We provide critical insights respect potential mechanisms explaining effects affecting muciniphila. Anthocyanins, flavan-3-ols, flavonols, flavanones, stilbenes, acids are shown increase levels vivo, whereas lignans exert opposite effect. Clinical trials show consistent findings, high intervariability relying microbiota composition at baseline presence multiple polyphenol degraders appear be cardinal determinants inducing associated benefits by intake. Polyphenols signal AhR receptor impact direct indirect fashion, resulting restoration intestinal epithelial integrity homeostatic crosstalk IL-22 production. Moreover, recent evidence suggests that participates initial hydrolysis some but does not participate their complete metabolism. In conclusion, consumption polyphenol-rich foods targeting pivotal intermediary represents promising precision nutritional therapy prevent attenuate diseases.

Language: Английский

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