Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(17), P. 9480 - 9488

Published: Feb. 6, 2021

Abstract The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed PEGylated manganese‐based SAE (Mn/PSAE) by coordination manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion cellular H 2 O . OH through Fenton‐like reaction; it also promotes decomposition and continuously cytotoxic − via oxidase‐like activity more pronounced weak acidic tumor environment; therefore, these cascade reactions enable sufficient generation reactive oxygen species (ROS) effectively kill cells. prominent photothermal property amorphous carbon can be utilized for therapy. Hence, significant therapeutic efficacy microenvironment stimulated multiple ROS

Language: Английский

---

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 14, 2022

Abstract Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb bowel disease (IBD). Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress (ECN-pE) for treatment To improve bioavailability ECN-pE gastrointestinal tract, chitosan sodium alginate, effective biofilms, were used coat via layer-by-layer electrostatic self-assembly strategy. In mouse IBD model induced different chemical drugs, chitosan/sodium alginate coating (ECN-pE(C/A) 2 ) relieved inflammation repaired epithelial barriers colon. Unexpectedly, EcN-pE(C/A) could also regulate microbial communities abundance Lachnospiraceae _NK4A136 Odoribacter flora, which are important microbes maintain homeostasis. Thus, this study lays foundation development living therapeutic proteins using probiotics treat intestinal-related diseases.

Language: Английский

---

Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

---

Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Feb. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Language: Английский

---

An overview of the use of nanozymes in antibacterial applications

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 418, P. 129431 - 129431

Published: March 21, 2021

Language: Английский

---

Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 15, 2022

The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part regulation reactive oxygen species (ROS), attracted extensive research interest in recent years. However, CAT-like are not well discussed other such peroxidase (POD)-like nanozymes, etc. Compared with natural or artificial CAT enzymes, have unique properties low cost, size-dependent properties, high catalytic activity and stability, easy surface modification, etc., which make them widely used fields, especially tumor therapy disease treatment. Consequently, there is a great requirement to systematic discussion on nanozymes. In this review, some key aspects deeply summarized as: 1) Typical classified by different nanomaterials; 2) mechanisms proposed experimental theoretical studies; 3) Extensive applications regard therapy, cytoprotection sensing. Therefore, it prospected that review will contribute further design optimize their much higher efficiency than before.

Language: Английский

---

Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(6), P. 617 - 627

Published: March 27, 2023

Language: Английский

---

Advances in metal–organic framework-based nanozymes and their applications

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 449, P. 214216 - 214216

Published: Sept. 15, 2021

Language: Английский

---

An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Oct. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Language: Английский

---

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

---