Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes DOI Creative Commons
Tim ten Brink, Febriyani Damanik, Jan Rotmans

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: Jan. 13, 2024

Abstract Biomaterials are defined as “engineered materials” and include a range of natural synthetic products, designed for their introduction into interaction with living tissues. considered prominent tools in regenerative medicine that support the restoration tissue defects retain physiologic functionality. Although commonly used medical field, these constructs inherently foreign toward host induce an immune response at material–tissue interface, body (FBR). A strong connection between regeneration is suggested, which appropriate amount macrophage polarization necessary to trigger autologous formation. Recent developments this field have led characterization immunomodulatory traits optimizes bioactivity, integration biomaterials determines fate regeneration. This review addresses variety aspects involved steering inflammatory response, including cell interactions, physical characteristics, biochemical cues, metabolomics. Harnessing advancing knowledge FBR allows optimization biomaterial‐based implants, aiming prevent damage implant, improve regeneration, provide efficient successful vivo implantation.

Language: Английский

Fibroblasts: Origins, definitions, and functions in health and disease DOI Creative Commons
Maksim V. Plikus, Xiaojie Wang, Sarthak Sinha

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(15), P. 3852 - 3872

Published: July 1, 2021

Language: Английский

Citations

681
Tuning immunity through tissue mechanotransduction DOI Open Access
Huixun Du, Juliet M. Bartleson, Sergei Butenko

et al.

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(3), P. 174 - 188

Published: Aug. 16, 2022

Language: Английский

Citations

230
Immune Modulatory Properties of Collagen in Cancer DOI Creative Commons
Anne Mette Askehøj Rømer, Marie‐Louise Thorseth, Daniel H. Madsen

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 8, 2021

During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The normal ECM is degraded and substituted with a tumor-specific ECM, which often of higher collagen density increased stiffness. structure has been associated poor prognosis in several types cancer. However, reason for this association still largely unknown. Collagen can promote cancer cell migration, but recent studies have shown that collagens also affect function phenotype various tumor-infiltrating immune cells such as tumor-associated macrophages (TAMs) T cells. This suggests could important modulatory functions within microenvironment, affecting progression well efficacy immunotherapy. effects on help explain why high tumors correlated prognosis. Knowledge about potentially identify targets improving current therapies or development new treatments. In review, knowledge ability to influence activity will be summarized. includes direct interactions induction suppressive other macrophages. Additionally, potential immunotherapy discussed.

Language: Английский

Citations

140
A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair DOI Creative Commons
T. David Luo, Bowen Tan,

Lengjing Zhu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Jan. 25, 2022

Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability water solubility. Especially, stiffness hydrogels is key factor, which influence morphology mesenchymal stem cells (MSCs) differentiation. The researches on this point are meaningful field engineering. Herein, review focus design with different effects behavior MSCs. In addition, effect hydrogel phenotype macrophages introduced, then relationship between changes inflammatory response discussed. Finally, future application certain medicine prospected.

Language: Английский

Citations

115
Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer DOI Creative Commons
Yuan Xiong, Qian Feng, Li Lü

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(10)

Published: Jan. 1, 2023

Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.

Language: Английский

Citations

77
Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy DOI Creative Commons
Yufeng Shou,

Xin Yong Teo,

Kenny Zhuoran Wu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(21)

Published: April 29, 2023

Abstract Cells interact with their surrounding environment through a combination of static and dynamic mechanical signals that vary over stimulus types, intensity, space, time. Compared to such as stiffness, porosity, topography, the current understanding on effects stimulations cells remains limited, attributing lack access devices, complexity experimental set‐up, data interpretation. Yet, in pursuit emerging translational applications (e.g., cell manufacturing for clinical treatment), it is crucial understand how respond variety forces are omnipresent vivo so they can be exploited enhance therapeutic outcomes. With rising appreciation extracellular matrix (ECM) key regulator biofunctions, researchers have bioengineered suite ECM‐mimicking hydrogels, which fine‐tuned spatiotemporal cues model complex profiles. This review first discusses stimuli may impact different cellular components various mechanobiology pathways involved. Then, hydrogels designed incorporate parameters influence behaviors described. The Scopus database also used analyze relative strength evidence, ranging from strong weak, based number published literatures, associated citations, treatment significance. Additionally, impacts clinically relevant types including mesenchymal stem cells, fibroblasts, immune evaluated. aim draw attention paucity studies well highlight potential using cocktail intensities fates (similar concept biochemical direct fate). It envisioned this progress report will inspire more exciting development mechanoresponsive biomedical applications.

Language: Английский

Citations

52
Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review DOI Creative Commons
Arun Rajendran,

D. Sankar,

Sivashanmugam Amirthalingam

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Sensing the mechanical properties of substrates or matrix by cells and tissues, subsequent downstream responses at cellular, nuclear epigenetic levels outcomes are beginning to get unraveled more recently. There have been various instances where researchers established underlying connection between cellular mechanosignalling pathways physiology, differentiation, also tissue pathology. It has now accepted that mechanosignalling, alone in combination with classical pathways, could play a significant role fate determination, development, organization tissues. Furthermore, as mechanobiology is gaining traction, so do techniques ponder gain insights into still pathways. This review would briefly discuss some interesting works wherein it shown specific alteration lead determination stem differentiated such osteoblasts, adipocytes, tenocytes, cardiomyocytes, neurons, how these being utilized for development organoids. cover developed employed explore effects including imaging mechanosensing proteins, atomic force microscopy (AFM), quartz crystal microbalance dissipation measurements (QCMD), traction (TFM), microdevice arrays, Spatio-temporal image analysis, optical tweezer measurements, mechanoscanning ion conductance (mSICM), acoustofluidic interferometric device (AID) forth. provide who work on exploiting control functions engineering regenerative applications, will shed light advancements be unravel unknown field mechanobiology.

Language: Английский

Citations

43
Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing DOI Creative Commons
Sergei Butenko, Raji R. Nagalla, Christian F. Guerrero‐Juarez

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 9, 2024

Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue repair. This study investigates how crosslinking of gelatin-based hydrogels influences immune and stromal cell behavior healing in female mice. We observe that softer, lightly crosslinked promote greater cellular infiltration result smaller scars compared stiffer, heavily hydrogels. Using single-cell RNA sequencing, we further show increase inflammation lead the formation a distinct macrophage subpopulation exhibiting signs oxidative activity fusion. Conversely, are more readily taken up by macrophages integrated within tissue. The physical properties differentially affect fibroblast interactions, promoting pro-fibrotic drives fusion through RANKL signaling. These findings suggest tuning can guide responses improve healing, offering insights for designing better biomaterials treatment.

Language: Английский

Citations

41
Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases DOI
Vincent Mittelheisser, Valentin Gensbittel, Lucia Bonati

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(3), P. 281 - 297

Published: Jan. 29, 2024

Language: Английский

Citations

27
Mechanosensing regulates tissue repair program in macrophages DOI Creative Commons
Matthew L. Meizlish, Yoshitaka Kimura, Scott D. Pope

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(11)

Published: March 13, 2024

Tissue-resident macrophages play important roles in tissue homeostasis and repair. However, how monitor maintain integrity is not well understood. The extracellular matrix (ECM) a key structural organizational component of all tissues. Here, we find that sense the mechanical properties ECM to regulate specific repair program. We show macrophage mechanosensing mediated by cytoskeletal remodeling can be performed three-dimensional environments through noncanonical, integrin-independent mechanism analogous amoeboid migration. these dynamics also integrate biochemical signaling colony-stimulating factor 1 ultimately chromatin accessibility control mechanosensitive gene expression This study identifies an "amoeboid" mode which may fibrosis.

Language: Английский

Citations

23