A shifting role of thalamocortical connectivity in the emergence of large-scale functional brain organization during early lifespan DOI Creative Commons

Shinwon Park,

Koen V. Haak, Stuart Oldham

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract While cortical patterning has been a perennial research topic in neuroscience, the mechanism for its consequence, namely functional specialization at macro scale, remains an open question human brain. Here, we focused on age-dependent changes of resting-state thalamocortical connectivity to investigate role emergence large-scale networks across infancy, childhood and young adulthood. We found that during infancy reflects early differentiation sensorimotor genetically-influenced axonal projection. This initial thalamus, however, seems change childhood, by establishing with salience network decoupling externally- internally-oriented processes. Developmental simulation perturbation analyses corroborated these findings, demonstrating highest contribution thalamic connectivity, especially later age youth, formation key characteristics mature brain, such as gradient hierarchy. Our study highlights developmentally shifting thalamus orchestrating complex brain organization potential implications developmental conditions characterized compromised internal external processing.

Language: Английский

Structure–function coupling in macroscale human brain networks DOI
Panagiotis Fotiadis, Linden Parkes, Kathryn A. Davis

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(10), P. 688 - 704

Published: Aug. 5, 2024

Language: Английский

Citations

27
Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy DOI Creative Commons
Audrey Luo, Valerie J. Sydnor, Adam Pines

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 25, 2024

Abstract Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices transmodal association cortices. Here, we investigate hypothesis development functional connectivity during childhood through adolescence conforms hierarchy defined by axis. We tested this pre-registered in four large-scale, independent datasets (total n = 3355; ages 5–23 years): Philadelphia Neurodevelopmental Cohort ( 1207), Nathan Kline Institute-Rockland Sample 397), Connectome Project: Development 625), and Healthy Brain Network 1126). Across datasets, systematically varied Connectivity regions increased, whereas declined, refining reinforcing hierarchy. These consistent generalizable results establish encodes dominant pattern development.

Language: Английский

Citations

18
Six cornerstones for translational brain charts DOI Open Access
Zixuan Zhou, Lizhen Chen, Michael P. Milham

et al.

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(8), P. 795 - 799

Published: March 30, 2023

Language: Английский

Citations

23
In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth DOI Creative Commons
Shaoshi Zhang, Bart Larsen, Valerie J. Sydnor

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(23)

Published: May 30, 2024

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I remains unknown. Here, we noninvasively estimate a putative marker whole-cortex by fitting large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our generates realistic dynamics in the Human Connectome Project. Next, show estimated sensitive gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced changes are spatially consistent with positron emission tomography measurement receptor density. then investigate relationship between and neurodevelopment. find declines heterogeneously across cerebral cortex youth, greatest reduction occurring sensorimotor systems relative association systems. Importantly, among children same chronological age, lower (especially cortex) linked better cognitive performance. This result replicated North American (8.2 23.0 y old) Asian (7.2 7.9 cohorts, suggesting more mature indexes improved cognition normative development. Overall, findings open door studying how disrupted trajectories may lead dysfunction psychopathology emerges youth.

Language: Английский

Citations

15
Which client with generalized anxiety disorder benefits from a mindfulness ecological momentary intervention versus a self-monitoring app? Developing a multivariable machine learning predictive model DOI
Nur Hani Zainal, Michelle G. Newman

Journal of Anxiety Disorders, Journal Year: 2024, Volume and Issue: 102, P. 102825 - 102825

Published: Jan. 5, 2024

Language: Английский

Citations

8
A general exposome factor explains individual differences in functional brain network topography and cognition in youth DOI Creative Commons
Arielle S. Keller, Tyler M. Moore, Audrey Luo

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 66, P. 101370 - 101370

Published: April 1, 2024

Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping childhood environments, we can now build upon prior studies that have considered relationships between one or a handful environmental and features at time. Here, characterize combined effects hundreds inter-connected co-occurring child's environment ("exposome") investigate associations each unique, multidimensional pattern functional brain network organization ("functional topography") cognition. We apply data-driven computational models to measure exposome define personalized networks pre-registered analyses. Across matched discovery (n=5,139, 48.5% female) replication (n=5,137, 47.1% samples from Adolescent Brain Cognitive Development study, was associated current (ages 9-10) future 11-12) Changes were also changes cognition after accounting for baseline scores. Cross-validated ridge regressions revealed is reflected topography predict performance across domains. Importantly, single capturing could more accurately parsimoniously than wealth data, highlighting importance children's complex,

Language: Английский

Citations

8
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization DOI

Shinwon Park,

Koen V. Haak, Stuart Oldham

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(8), P. 1609 - 1619

Published: June 10, 2024

Language: Английский

Citations

7
Diverse adolescents’ transcendent thinking predicts young adult psychosocial outcomes via brain network development DOI Creative Commons
Rebecca Gotlieb, Xiao‐Fei Yang, Mary Helen Immordino‐Yang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 15, 2024

Abstract Developmental scientists have long described mid-adolescents’ emerging capacities to make deep meaning about the social world and self, here called transcendent thinking, as a hallmark developmental stage. In this 5-years longitudinal study, sixty-five 14–18 years-old youths’ proclivities grapple psychologically with ethical, systems-level personal implications of stories, predicted future increases in coordination two key brain networks: default-mode network, involved reflective, autobiographical free-form executive control effortful, focused thinking; findings were independent IQ, ethnicity, socioeconomic background. This neural development late-adolescent identity development, which young-adult self-liking relationship satisfaction, cascade. The reveal novel predictor suggest importance attending adolescents’ engage agentically complex perspectives emotions on relevance issues, such through civically minded educational approaches.

Language: Английский

Citations

6
Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance DOI Creative Commons
Jiao Li, Chao Zhang, Yao Meng

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(6), P. e3002647 - e3002647

Published: June 20, 2024

The human brain is organized as segregation and integration units follows complex developmental trajectories throughout life. cortical manifold provides a new means of studying the brain’s organization in multidimensional connectivity gradient space. However, how morphometric changes across lifespan remains unclear. Here, leveraging structural magnetic resonance imaging scans from 1,790 healthy individuals aged 8 to 89 years, we investigated age-related global, within- between-network dispersions reveal networks 3D manifolds based on similarity network (MSN), combining multiple features conceptualized “fingerprint” an individual’s brain. Developmental global dispersion unfolded along patterns molecular organization, such acetylcholine receptor. Communities were increasingly dispersed with age, reflecting more disassortative profiles within community. Increasing within-network primary motor association cortices mediated influence age cognitive flexibility executive functions. We also found that secondary sensory decreasingly rest during aging, possibly indicating shift extreme central position manifolds. Together, our results MSN perspective space, providing insights into brain, well performance.

Language: Английский

Citations

6
Socioeconomic resources in youth are linked to divergent patterns of network integration/segregation across the brain’s transmodal axis DOI Creative Commons
Cleanthis Michael, Aman Taxali, Mike Angstadt

et al.

PNAS Nexus, Journal Year: 2024, Volume and Issue: 3(9)

Published: Sept. 1, 2024

Abstract Socioeconomic resources (SER) calibrate the developing brain to current context, which can confer or attenuate risk for psychopathology across lifespan. Recent multivariate work indicates that SER levels powerfully relate intrinsic functional connectivity patterns entire brain. Nevertheless, neuroscientific meaning of these widespread neural differences remains poorly understood, despite its translational promise early identification, targeted intervention, and policy reform. In present study, we leverage graph theory precisely characterize univariate associations between household neighborhood contexts architecture regions in 5,821 youth (9–10 years) from Adolescent Brain Cognitive Development Study. First, establish decomposing into profiles integration segregation captures more than half association with greater parsimony (100-fold reduction number features) interpretability. Second, show topological effects are not uniform brain; rather, higher associated somatomotor subcortical systems, but default mode, orbitofrontal, cerebellar systems. Finally, demonstrate spatially patterned along unimodal–transmodal gradient organization. These findings provide critical interpretive context established This study highlights both higher-order networks differentially implicated environmental stress, disadvantage, opportunity youth.

Language: Английский

Citations

6