Dynamic population coding of social novelty in the insular cortex DOI Creative Commons
Masaaki Sato,

Eric T. N. Overton,

Shuhei Fujima

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Abstract The familiarity of socially interacting peers has a profound impact on behavior 1–3 , but little is known about the neuronal representations distinguishing familiar from novel conspecifics. insular cortex (IC) regulates social 4–9 and our previous study revealed that neurons in agranular IC (aIC) encode ongoing interactions 10 . To elucidate how these discriminate between with conspecifics, we monitored activity mice by microendoscopic calcium imaging during recognition memory (SRM) linear chamber discrimination (LCSD) tasks. In SRM task, repeated same target activated largely nonoverlapping cells each session. fraction associated investigation (social cells) decreased as subject repeatedly interacted target, whereas substitution second subsequent exchange first recruited more new cells. LCSD addition to an area containing transiently increased number responding both targets, followed eventual increase target. These results support view aIC dynamically encodes novelty, rather than consistently identity, rapidly reorganizing neural conspecific information.

Language: Английский

Optogenetic stimulation of cell bodies versus axonal terminals generate comparable activity and functional connectivity patterns in the brain DOI Creative Commons
Li‐Ming Hsu, Domenic H. Cerri, Regina M. Carelli

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Optogenetic techniques are often employed to dissect neural pathways with presumed specificity for targeted projections. In this study, we used optogenetic fMRI investigate the effective landscape of stimulating cell bodies versus one its projection terminals. Specifically, selected a long-range unidirectional from ventral subiculum (vSUB) nucleus accumbens shell (NAcSh) and placed two fibers-one at vSUB other terminals in NAcSh. Contrary conventional view that terminal stimulation confines activity feedforward stimulated pathway, our findings reveal induces brain connectivity patterns remarkably similar those body stimulation. This observation suggests may induce antidromic activation, leading broader network involvement than previously acknowledged.

Language: Английский

Citations

0
Biophysical mechanisms of default mode network function and dysfunction DOI Creative Commons
Trang-Anh E. Nghiem, Vinod Menon

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The default mode network (DMN) plays a fundamental role in internal cognitive function as well dysfunction across numerous brain disorders. While human and rodent neuroimaging has revealed DMN suppression by salient external stimuli, the cellular mechanisms orchestrating this process remain unknown. Using whole-brain computational modeling informed neuronal biophysics retrograde tracer-derived directional mouse connectomics, we demonstrate that stimulation of insula, involved salience processing, suppresses activity while within-DMN cingulate enhances it. Manipulating excitatory-inhibitory balance how localized disruptions propagate to cause distinct patterns dysfunction, with both reversals paradoxical enhancements normal patterns. Brain-wide response analysis uncovered functionally segregated frontal hierarchical organization from regions. These findings provide unified framework linking large-scale dynamics region-specific might lead observed

Language: Английский

Citations

0
Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats DOI Creative Commons
Li‐Ming Hsu, Domenic H. Cerri, Sung‐Ho Lee

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(7), P. e1452232023 - e1452232023

Published: Jan. 17, 2024

While functional brain imaging studies in humans suggest that chronic cocaine use alters connectivity (FC) within and between key large-scale networks, including the default mode network (DMN), salience (SN), central executive (CEN), cross-sectional are challenging to obtain FC prior use. Such information is critical reveal relationship individual's subsequent development of dependence changes during abstinence. Here, we performed a longitudinal study examining magnetic resonance (fMRI) data male rats ( n = 7), acquired before self-administration (baseline), on 1 d abstinence following 10 self-administration, again after 30 experimenter-imposed Using repeated-measures analysis variance (ANOVA) with network-based statistics (NBS), significant were found anterior insular cortex (AI) SN, retrosplenial (RSC) DMN, somatosensory cortex, caudate–putamen (CPu), AI–RSC showing most robust baseline Additionally, level escalated intake associated AI–CPu abstinence; further, subjects’ moderator for These results provide novel insights into roles this circuit be potential target modulate behavioral disorders.

Language: Английский

Citations

3
NIMH perspectives on future directions in neuroimaging for mental health DOI Creative Commons
S. Andrea Wijtenburg, Laura M. Rowland,

Aleksandra Vicentic

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 294 - 297

Published: June 19, 2024

Abstract NIMH’s mission is to transform the understanding and treatment of mental illnesses through basic clinical research, paving way for prevention, recovery, cure. New imaging techniques hold great promise improving our pathophysiology illnesses, stratifying patients selection, developing a personalized medicine approach. Here, we highlight emerging promising new technologies that are likely be vital in helping NIMH accomplish its mission, potential utilizing multimodal approaches study illness, considerations data analytics sharing.

Language: Английский

Citations

3
Default mode network dynamics: an integrated neurocircuitry perspective on social dysfunction in human brain disorders DOI Creative Commons
Mirthe Ronde, Eddy A. van der Zee, Martien J. Kas

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105839 - 105839

Published: Aug. 2, 2024

Language: Английский

Citations

3
Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats DOI Creative Commons
Sung‐Ho Lee, Tatiana A. Shnitko, Li‐Ming Hsu

et al.

Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 7, P. 100105 - 100105

Published: June 2, 2023

Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that alcohol use affects frontal brain regions are important for cognitive control over behavior little known about how acute exposure alters large-scale networks and sex age may moderate such effects. Here, we employ recently developed functional magnetic resonance imaging (fMRI) protocol to acquire rat connectivity data an established analytical pipeline examine the effect of sex, age, dose on within between three rodent networks: defaul mode, salience, lateral cortical network. We identify intra- inter-network differences establish moderation models reveal significant influences alcohol-induced network connectivity. Through this work, make brain-wide isotropic fMRI with challenge publicly available, hope facilitate future discovery regions/circuits causally relevant impact use.

Language: Английский

Citations

7
Space wandering in the rodent default mode network DOI
Trang-Anh E. Nghiem, Byeongwook Lee, Tzu-Hao Harry Chao

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(15)

Published: April 1, 2024

The default mode network (DMN) is a large-scale brain known to be suppressed during wide range of cognitive tasks. However, our comprehension its role in naturalistic and unconstrained behaviors has remained elusive because most research on the DMN been conducted within restrictive confines MRI scanners. Here, we use multisite GCaMP (a genetically encoded calcium indicator) fiber photometry with simultaneous videography probe function awake, freely exploring rats. We examined neural dynamics three core nodes—the retrosplenial cortex, cingulate prelimbic cortex—as well as anterior insula node salience network, their association rats’ spatial exploration behaviors. found that nodes displayed hierarchical functional organization exploration, characterized by stronger coupling each other than insula. Crucially, these kinematics including linear angular velocity. Additionally, identified latent states distinct patterns time-varying higher velocity was associated enhanced activity, heightened synchronization among nodes, increased anticorrelation between Our findings highlight involvement collectively dynamically encoding real-world setting. challenge notion primarily “task-negative” disengaged from external world. By illuminating DMN’s behaviors, study underscores importance investigating ecologically valid contexts.

Language: Английский

Citations

2
Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders DOI Creative Commons
Xiong Chen,

Chunqi Ai,

Zhongchun Liu

et al.

BMC Medical Imaging, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 7, 2024

Eating disorders (EDs), including anorexia nervosa (AN), bulimia (BN), binge-eating disorder (BED), and pica, are psychobehavioral conditions characterized by abnormal eating behaviors an excessive preoccupation with weight body shape. This review examines changes in brain regions functional connectivity ED patients over the past decade (2013-2023) using resting-state magnetic resonance imaging (rs-fMRI). Key findings highlight alterations networks such as default mode network (DMN), central executive (CEN), emotion regulation (ERN). In individuals AN, there is reduced areas associated facial information processing social cognition, alongside increased linked to sensory stimulation, aesthetic judgment, anxiety. Conversely, BED show diminished dorsal anterior cingulate cortex within salience posterior medial prefrontal DMN. These suggest that rs-fMRI could serve a valuable biomarker for assessing function predicting treatment outcomes EDs, paving way personalized therapeutic strategies.

Language: Английский

Citations

2
Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial DOI Creative Commons
Weidong Cai, Yoshifumi Mizuno, Akemi Tomoda

et al.

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(11), P. 1690 - 1698

Published: July 25, 2023

Abstract Methylphenidate is a widely used and effective treatment for attention-deficit/hyperactivity disorder (ADHD), yet the underlying neural mechanisms their relationship to changes in behavior are not fully understood. Specifically, it remains unclear how methylphenidate affects brain behavioral dynamics, interplay between these individuals with ADHD. To address this gap, we novel Bayesian dynamical system model investigate effects of on latent states 27 children ADHD 49 typically developing using double-blind, placebo-controlled crossover design. remediated greater variability continuous performance task Children exhibited aberrant state dynamics compared children, single showing particularly abnormal which was by methylphenidate. Additionally, showed state-dependent hyper-connectivity default mode network, also Finally, found that methylphenidate-induced as well state-related functional connectivity salience networks, were correlated improvements variability. Taken together, our findings reveal process circuit mechanism therapeutic childhood We suggest models may be useful capturing complex nonlinear activity associated Our approach value clinicians researchers investigating pharmacological psychiatric disorders.

Language: Английский

Citations

5
Epilepsy alters brain networks in patients with insular glioma DOI Creative Commons

Qifeng He,

Zuocheng Yang,

Bowen Xue

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: June 1, 2024

Abstract Aims We intend to elucidate the alterations of cerebral networks in patients with insular glioma‐related epilepsy (GRE) based on resting‐state functional magnetic resonance images. Methods collected 62 glioma patients, who were subsequently categorized into and no (GnE) groups, recruited 16 healthy individuals matched patient's age gender form control (HC) group. Graph theoretical analysis was applied reveal differences sensorimotor, default mode, visual, executive among different subgroups. Results No significant connectivity found either hemisphere glioma. Using graph analysis, mode ( p < 0.05). When located left hemisphere, degree centrality reduced GE group compared GnE right insula, centrality, nodal efficiency, local clustering coefficient lower than those Conclusion The impact itself GRE brain network is widespread. altered by differ depending location. reduces properties that

Language: Английский

Citations

1