Cuproptosis: an emerging domain for copper-based nanomaterials mediated cancer therapy DOI
Fan Zhao,

Zhuangzhuang Zhao,

Hao Gao

et al.

MedMat., Journal Year: 2024, Volume and Issue: 1(2), P. 74 - 94

Published: Dec. 1, 2024

Cuproptosis, a newly discovered copper-dependent mode of cell death, has received extensive attention in the field cancer therapy due to its specific activation pathway. Rapid accumulation large amounts copper ions within cells achieve overload is key activating cuproptosis. Advanced nanotechnology offers considerable promise for delivering cells, which copper-based nanomaterials have been proposed evoke cuproptosis-mediated therapy. However, it still great challenge induce specifically tumors and efficiently activate subsequent cuproptosis-related molecular pathways. Therefore, necessary summarize strategies used effectively or amplify cuproptosis based on currently developed nanomaterials, providing ideas design future. In this review, that can be are systematically classified selection. Subsequently, sensitization using provided therapeutic efficiency. Meanwhile, combination therapies maximizing treatment efficacy delineated. Ultimately, remaining challenges feasible future directions use tumor also discussed.

Language: Английский

Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer DOI Creative Commons
Shipeng Ning,

Ping Shangguan,

Xinyan Zhu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7433 - 7444

Published: Feb. 20, 2025

The immunosuppressive tumor microenvironment in triple-negative breast cancer could hinder the response to thorough immunotherapy and diminish antitumor efficacy. Although STING pathway emerges as a promising target remedy defects, uncertain drug delivery might lead off-target inflammatory reactions. Here, we manifest novel phototheranostic agent with an aggregation-induced emission property that guided pharmacological activation of agonist for photothermal create immunologically "hot" tumor. A pyridinium rotor strategy is proposed develop positively charged TBTP-Bz, which stably coincorporated MSA-2 into thermal-responsive exosome-liposome hybrid nanoparticles tumor-targeting delivery. TBTP-Bz exhibits aggregation-enhanced NIR-II photoacoustic signal, accomplishing real-time tracking. Its stimulation induces immunogenic cell death promotes precise release MSA-2, thus boosting STING-mediated type I interferon production. Significantly, single-dose photoimmunotherapy effectively suppresses abscopal growth provokes immune memory effect inhibit postsurgical recurrent rechallenged tumors. This demonstrates clinical potential poorly cancer.

Language: Английский

Citations

2
Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma DOI
Muhammad Ismail,

Yibin Wang,

Y. M. Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis and limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great promise for improving the modalities of GBM. At beginning review, we highlighted stimuli-active polymeric carrying therapies that potentially boost anti-GBM responses employing endogenous (pH, redox, hypoxia, enzyme) or exogenous stimuli (light, ultrasonic, magnetic, temperature, radiation) as triggers controlled drug release mainly via hydrophobic/hydrophilic transition, degradability, ionizability, etc. Modifying these target ligands further enhanced their capacity to traverse blood-brain barrier (BBB) preferentially accumulate in glioma cells. These unique features lead more effective cancer minimal adverse reactions superior therapeutic outcomes. Finally, review summarizes existing difficulties future prospects treating Overall, this offers theoretical guidelines developing intelligent versatile facilitate precise GBM clinical settings.

Language: Английский

Citations

8
Large-scale transcript variants dictate neoepitopes for cancer immunotherapy DOI Creative Commons
Shiliang Ji, Feifan Wang, Yongjie Wu

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(5)

Published: Jan. 31, 2025

Precise neoepitope discovery is crucial for effective cancer therapeutic vaccines. Conventional approaches struggle to build a repertoire with sufficient immunogenic epitopes. We developed workflow leveraging full-length ribosome–nascent chain complex–bound mRNA sequencing (FL-RNC seq) and artificial intelligence–based predictive models accurately identify the landscape, especially large-scale transcript variants (LSTVs) missed by short-read sequencing. In MC38 mouse model, we identified 22 LSTV-derived neoepitopes encoded synthesized lipid nanoparticle vaccine. As standalone therapy combined anti–PD-1 immunotherapy, vaccine curbed tumor progression, induced robust T cell–specific immunity, modulated microenvironment. This underscores multifaceted potentials of Our approach expands source repertoire, offering method discovering personalized vaccines applicable broader range. The results highlight importance comprehensive identification promise LSTV-based immunotherapy.

Language: Английский

Citations

1
Redox-responsive metal-organic framework nanocapsules enhance tumor chemo-immunotherapy by modulating tumor metabolic reprogramming DOI Creative Commons
Yuman Dong, Jieru Li,

Yiwei Dai

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101487 - 101487

Published: Jan. 13, 2025

Language: Английский

Citations

0
A Nanoimmunoactivator Induces Endoplasmic Reticulum Stress and Alleviates the Immunosuppression for Synergistic Cancer Immunotherapy DOI Open Access
Hui Qi, Zhanzhan Zhang,

Yu Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Cancer immunotherapy has transformed the landscape of cancer treatment. However, low immunogenicity and immunosuppressive tumor microenvironment (TME) often limit efficacy immunotherapy. Activating immune responses while alleviating negative feedback regulation offers a promising strategy to enhance effectiveness Herein, this work proposes novel nanoparticle‐based activator (nanoIA), which can induce immunogenic cell death (ICD) cells deliver small‐molecule immunomodulators further antitumor responses. NanoIA features unique surface structure that enables it ICD by targeting retaining in endoplasmic reticulum cells. Additionally, nanoIA be loaded with various drugs released response stimuli from TME. This distinct capability initiate amplify study employs two immunomodulators, JQ1 NLG919, as examples for demonstration. NanoIA/JQ1 nanoIA/NLG919 demonstrated significant inhibiting growth, prolonging survival tumor‐bearing mice, preventing recurrence metastasis. These results confirm nanoIA's ability activate memory. provides new insights into development nanoparticles actively participate regulation.

Language: Английский

Citations

0
A Bifunctional Lysosome‐Targeting Chimera Nanoplatform for Tumor‐Selective Protein Degradation and Enhanced Cancer Immunotherapy DOI Open Access

Yumeng Xing,

Jingjing Li,

Leyuan Wang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Lysosome-targeting chimeras (LYTACs) have recently emerged as a promising therapeutic strategy for degrading extracellular and membrane-associated pathogenic proteins by hijacking lysosome-targeting receptors. However, the antitumor performance of LYTAC is limited its insufficient tumor accumulation nonspecific activation. Additionally, synergistic effects LYTACs other modalities are crucial. To address these issues, bifunctional nanoplatform (NLTC) developed tumor-selective protein degradation enhanced cancer immunotherapy. By rationally controlling surface composition, NLTC can effectively transport or membrane into lysosomes via cation-independent mannose 6-phosphate With removable modification, an obtained that efficiently accumulated in tissues avoided on-target off-tumor toxicity. Moreover, synthesis method generally applicable to various enzymes. Thus, catalase (CAT) encapsulated with synergistically degrade cell programmed death ligand-1 (PD-L1), relieve immunosuppressive microenvironment effective immunotherapy, significantly inhibit growth, recurrence, metastasis B16F10-bearing mice. This work presents not only perform tissue-selective but also integrate modalities, providing insights design advanced technologies clinical applications.

Language: Английский

Citations

0
Topology‐Oriented Lymph Node Drainage of Dendritic Polymer‐TLR Agonist Conjugates to Enhance Vaccine Immunogenicity DOI Open Access
Long Ren, Bing Wang,

Di Miao

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Strategically targeting lymph nodes (LNs) to orchestrate the initiation and regulation of adaptive immune responses is one most pressing challenges in context vaccination. Herein, a series polymer-TLR agonist conjugates (PTACs) developed investigate impact dendritic-topological characteristics on their LN activity vivo, molecular weight (MW) pharmacokinetics support homing. Notably, dendritic 6-arm PTAC with MW 60 kDa (6A-PTAC-60k) rapidly delivered cargo draining LNs after administration peripheral tissues. Specifically, this topologic structure ameliorated behavior within lymphatic vessels LNs, including an elevated amount TLR7/8 improved distribution pattern among barrier cells cells, increased permeability, prolonged retention. Furthermore, 6A-PTAC-60k formulation induced broad antibody T cell responses, enhancing vaccine immunogenicity suppressing tumor growth. The results revealed that both topology polymers are crucial factors for immunoadjuvant functional which, turn, enhanced formulation. This study may provide chemical structural basis optimizing design delivery systems.

Language: Английский

Citations

0
Metal-based immunogenic cell death inducers for cancer immunotherapy DOI Creative Commons
Jun Zou, Meng Rui Chang, Nikita A. Kuznetsov

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Language: Английский

Citations

0
Nano-immunomodulators for multi-pathway regulation of immunosuppressive microenvironment of colorectal cancer DOI
Xianghui Cao, Nana Feng, Qingqing Huang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161104 - 161104

Published: Feb. 1, 2025

Language: Английский

Citations

0
Enhancing immunogenicity and release of in situ-generated tumor vesicles for autologous vaccines DOI
Jinhu Chen,

Caili Zhao,

Jing Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113614 - 113614

Published: March 1, 2025

Language: Английский

Citations

0