2D Indium‐Vacancy‐Rich ZnIn2S4 Nanocatalysts for Sonocatalytic Cancer Suppression by Boosting Cancer‐Cell Pyroptosis DOI
Zeyu Wang, Xue Wang,

Hongsheng Fang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Sonocatalytic therapy is gaining interest for its non‐invasive nature, precise control, and excellent tissue penetration, making it a promising approach treating malignant tumors. While defect engineering enhances electron hole separation to boost reactive oxygen species (ROS) generation, challenges in constructing effective traps compared severely limit ROS production. In this study, 2D ZnIn 2 S 4 ‐V nanosheets enriched are rationally designed with vacancies the efficient capture of electrons holes, which has achieved substantial sonocatalytic performance suppressing tumor growth. Compared pristine nanosheets, possess periodic electrostatic potential inherent their structure, effectively disrupt field, promote simultaneous migration charge carriers, inhibit recombination, thereby boosting production inducing cell pyroptosis via ROS‐NLRP3‐caspase‐1‐GSDMD pathway under ultrasound (US) irradiation. Furthermore, both exhibited remarkable biocompatibility. vitro vivo antineoplastic experiments demonstrate that promotes elimination, underscoring critical importance defect‐engineered optimization therapy.

Language: Английский

Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy DOI Creative Commons
H.-B. Zhang, Yitong Zhang, Y. Zhang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.

Language: Английский

Citations

21
Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology DOI Creative Commons
Kai Jin, Yi Huang, Hailong Che

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These can be used individually or in combination microbial consortia. The components within these consortia complement each other, enhancing diagnostic accuracy providing synergistic effects that improve treatment efficacy. application of therapies cancer, intestinal diseases, metabolic disorders underscores their significant potential. impact on the host's native microbiota is crucial, microbes modulate interact with environment, influencing outcomes overall health. Despite numerous advancements, challenges remain. include ensuring long-term survival safety bacteria, developing new chassis gene editing techniques non-model strains, minimising potential toxicity, understanding bacterial interactions host microbiota. This mini-review examines current state disease diagnosis treatment, highlighting challenges, future directions this promising field.

Language: Английский

Citations

3
Artificial Intelligence in Gastrointestinal Cancer Research: Image Learning Advances and Applications DOI Creative Commons
Shengyuan Zhou,

Yi Xie,

Xujiao Feng

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 614, P. 217555 - 217555

Published: Feb. 12, 2025

Language: Английский

Citations

2
An Acceptor–Donor–Acceptor Structured Nano‐Aggregate for NIR‐Triggered Interventional Photoimmunotherapy of Cervical Cancer DOI

Gaoli Niu,

Xingqi Bi,

Yong Kang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (

Language: Английский

Citations

11
The emergence of cancer sono-immunotherapy DOI
Yuqi Yang, Yuan Cheng, Liang Cheng

et al.

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(7), P. 549 - 563

Published: June 23, 2024

Language: Английский

Citations

8
Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration DOI
Fangwei Qi, Wei Liu, Yanyan Chen

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 682, P. 210 - 221

Published: Nov. 28, 2024

Language: Английский

Citations

8
Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma DOI Open Access
Jiamin Ye,

Yueyue Fan,

Yong Kang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

Citations

7
Lactate/Cysteine Dual-Consuming Probiotic–Nanomedicine Biohybrid System for Enhanced Cancer Chemo-Immunotherapy DOI

Tian‐Qiu Xie,

Xiao Yan,

You‐Teng Qin

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(50), P. 16132 - 16142

Published: Dec. 6, 2024

Immunotherapy is revolutionizing oncology, but its therapeutic efficiency still limited by the off-target toxicities and poor antitumor immune responses. By integrating drug-loaded nanoparticles (DMnSH) with unique metabolic traits of Veillonella parvula (Vei), a probiotic–nanomedicine conjugate Vei@DMnSH biohybrid elaborately designed for enhanced cancer chemo-immunotherapy. Specifically, can accumulate in hypoxic tumor sites simultaneously consume lactate cysteine to reverse lactate-associated immunosuppression impede biosynthesis GSH. In addition, DMnSH will rapidly deplete intracellular GSH disassemble release DOX Mn2+. Accompanied two-pronged depletion, Mn2+-mediated Fenton-like reaction effectively generate oxidative hydroxyl radicals induce heavy redox imbalance. Combined effect DOX, robust immunogenic cell death provoked subsequently activates adaptive immunity suppression rate over 82%, synergistically enhancing outcomes

Language: Английский

Citations

5
Quinoidal Semiconductor Nanoparticles for NIR‐II Photoacoustic Imaging and Photoimmunotherapy of Cancer DOI Open Access

Gaoli Niu,

Guangkun Song,

Yong Kang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Photoagents with ultra-high near-infrared II (NIR-II) light energy conversion efficiency hold great promise in tumor phototherapy due to their ability penetrate deeper tissues and minimize damage surrounding healthy cells. However, the development of NIR-II photoagents remain challenging. In this study, an all-fused-ring quinoidal acceptor-donor-acceptor (A-D-A) molecule, SKCN, a BTP core is synthesized, nanoparticles named FA-SNPs are prepared. The unique structure enhances π-electron delocalization bond length uniformity, significantly reducing bandgap resulting strong absorption, high molar extinction coefficient, photothermal 75.14%. Enhanced molecular rigidity also facilitates efficient transfer oxygen, boosting reactive oxygen species generation. By incorporating immunomodulator R848, FA-SRNPs further developed, effectively modulating immune microenvironment by Tregs M-MDSCs infiltration, promoting dendritic cell maturation, M1 macrophage polarization, activating CD8+ T cells NK Comprehensive studies using orthotopic ovarian cancer models demonstrated targeting, photoacoustic imaging capabilities, significant suppression metastasis inhibition, showing excellent therapeutic efficacy breast model. This study provides evidence for potential application A-D-A molecules photoimmunotherapy.

Language: Английский

Citations

4
Precision microbial regulation: Strategies for modulating GIT microbiota for host health DOI Creative Commons

Zhong Pei,

Qin Li, Yanmei Zhang

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of gastrointestinal tract (GIT) microbiota and their associations with host well‐being. Despite these insights, precise regulation GIT remains a significant challenge. Currently, microbial regulatory strategies, including fecal transplantation (FMT), synthetic communities (SynComs), genetically engineered microorganisms (GEMs), phages, nanomaterials, are increasingly utilized for influence on microbiota. This review emphasizes necessity developing targeted strategies provides comprehensive summary comparison approaches to explore potential. We discuss recent focusing mechanisms, efficacy, safety considerations, clinical trials, optimization at application level. Finally, we highlight support methods optimizing modulation timing regulation, selection targets, importance monitoring environment guide effective interventions.

Language: Английский

Citations

0