Coordination of circadian timing in mammals

Nature, Journal Year: 2002, Volume and Issue: 418(6901), P. 935 - 941

Published: Aug. 1, 2002

Language: Английский

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Solid-State Light Sources Getting Smart

Science, Journal Year: 2005, Volume and Issue: 308(5726), P. 1274 - 1278

Published: May 26, 2005

More than a century after the introduction of incandescent lighting and half fluorescent lighting, solid-state light sources are revolutionizing an increasing number applications. Whereas efficiency conventional lights is limited by fundamental factors that cannot be overcome, only human creativity imagination. The high already provides energy savings environmental benefits in However, also offer controllability their spectral power distribution, spatial color temperature, temporal modulation, polarization properties. Such "smart" can adjust to specific environments requirements, property could result tremendous automobiles, transportation, communication, imaging, agriculture, medicine.

Language: Английский

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Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

Science, Journal Year: 2002, Volume and Issue: 295(5557), P. 1070 - 1073

Published: Feb. 8, 2002

Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the pacemaker—the suprachiasmatic nucleus (SCN) of hypothalamus. Such photic entrainment requires neither rods nor cones, only known photoreceptors. Here, we show that ganglion cells innervating SCN are intrinsically photosensitive. Unlike other cells, they depolarized in response light even when all synaptic from and cones was blocked. The sensitivity, spectral tuning, slow kinetics this matched those mechanism, suggesting these may be primary photoreceptors for system.

Language: Английский

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The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

Annual Review of Physiology, Journal Year: 2010, Volume and Issue: 72(1), P. 517 - 549

Published: Feb. 11, 2010

Most physiology and behavior of mammalian organisms follow daily oscillations. These rhythmic processes are governed by environmental cues (e.g., fluctuations in light intensity temperature), an internal circadian timing system, the interaction between this timekeeping system signals. In mammals, has a complex architecture, composed central pacemaker brain's suprachiasmatic nuclei (SCN) subsidiary clocks nearly every body cell. The clock is synchronized to geophysical time mainly via photic perceived retina transmitted electrical signals SCN neurons. turn, influences neuronal humoral synchronization local oscillators that operative cells most organs tissues. Thus, some output pathways serve as input for peripheral Here we discuss knowledge acquired during past few years on structure function system.

Language: Английский

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Molecular components of the mammalian circadian clock

Human Molecular Genetics, Journal Year: 2006, Volume and Issue: 15(suppl_2), P. R271 - R277

Published: Sept. 20, 2006

Circadian rhythms are approximately 24-h oscillations in behavior and physiology, which internally generated function to anticipate the environmental changes associated with solar day. A conserved transcriptional-translational autoregulatory loop generates molecular of 'clock genes' at cellular level. In mammals, circadian system is organized a hierarchical manner, master pacemaker suprachiasmatic nucleus (SCN) regulates downstream oscillators peripheral tissues. Recent findings have revealed that clock cell-autonomous self-sustained not only central pacemaker, SCN, but also tissues dissociated cultured cells. It becoming evident specific contribution each component interactions among components vary tissue-specific manner. Here, we review general mechanisms clockwork, describe recent elucidate expression patterns genes address importance regulation for an organism's overall well-being.

Language: Английский

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Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN

Nature, Journal Year: 2005, Volume and Issue: 433(7027), P. 749 - 754

Published: Feb. 1, 2005

Language: Английский

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Sleep State Switching

Neuron, Journal Year: 2010, Volume and Issue: 68(6), P. 1023 - 1042

Published: Dec. 1, 2010

Language: Английский

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Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors

Chemical Reviews, Journal Year: 2003, Volume and Issue: 103(6), P. 2203 - 2238

Published: April 19, 2003

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and Function of DNA Photolyase Cryptochrome Blue-Light PhotoreceptorsAziz SancarView Author Information Department Biochemistry Biophysics, Mary Ellen Jones Building, CB 7260, University North Carolina School Medicine, Chapel Hill, 27599 Cite this: Chem. Rev. 2003, 103, 6, 2203–2238Publication Date (Web):April 19, 2003Publication History Received25 July 2002Published online19 April 2003Published inissue 1 June 2003https://pubs.acs.org/doi/10.1021/cr0204348https://doi.org/10.1021/cr0204348research-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views10780Altmetric-Citations1053LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Charge transfer,Flavins,Genetics,Oligomers,Peptides proteins Get e-Alerts

Language: Английский

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Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice

Nature, Journal Year: 2003, Volume and Issue: 424(6944), P. 75 - 81

Published: June 15, 2003

Language: Английский

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A clockwork web: circadian timing in brain and periphery, in health and disease

Nature reviews. Neuroscience, Journal Year: 2003, Volume and Issue: 4(8), P. 649 - 661

Published: Aug. 1, 2003

Language: Английский

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