S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

Science, Journal Year: 2018, Volume and Issue: 359(6371), P. 114 - 119

Published: Jan. 5, 2018

Inflammatory ILC2s are itinerant sentinels Group 2 innate lymphoid cells (ILC2s) a population of immune that play important roles in tissue homeostasis and barrier immunity to helminths. Recent work has suggested primarily long-term residents tissues do not readily recirculate. Huang et al. now demonstrate, however, these findings necessarily hold true for the interleukin-25 (IL-25)–responsive KLRG1 hi “inflammatory” ILC2 (iILC2) subset (see Perspective by Mjösberg Rao). In response exogenous IL-25 or helminth infection, iILC2 precursors small intestinal lamina propria proliferate alter their expression sphingosine 1-phosphate (S1P) receptors. They then traffic both lymphatic nonlymphatic organs partly S1P-dependent manner, participating vital anti-helminth repair responses. Science , this issue p. 114 ; see also 36

Language: Английский

---

The influence of the microbiome on respiratory health

Nature Immunology, Journal Year: 2019, Volume and Issue: 20(10), P. 1279 - 1290

Published: Sept. 9, 2019

Language: Английский

---

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(6), P. 636 - 645

Published: April 25, 2016

Language: Английский

---

NK cells and type 1 innate lymphoid cells: partners in host defense

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(7), P. 758 - 764

Published: June 21, 2016

Language: Английский

---

Emerging insights into natural killer cells in human peripheral tissues

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(5), P. 310 - 320

Published: April 28, 2016

Language: Английский

---

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

Cell, Journal Year: 2017, Volume and Issue: 171(4), P. 795 - 808.e12

Published: Oct. 19, 2017

Language: Английский

---

Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

Immunity, Journal Year: 2018, Volume and Issue: 48(6), P. 1104 - 1117

Published: June 1, 2018

Language: Английский

---

Hallmarks of Tissue-Resident Lymphocytes

Cell, Journal Year: 2016, Volume and Issue: 164(6), P. 1198 - 1211

Published: March 1, 2016

Language: Английский

---

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

European Journal of Immunology, Journal Year: 2021, Volume and Issue: 51(12), P. 2708 - 3145

Published: Dec. 1, 2021

Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes functional assays all major human murine immune cell subsets. Notably, contain helpful tables highlighting differences between cells. Another useful feature this is analysis clinical samples with examples applications in context autoimmune diseases, cancers as well acute chronic infectious diseases. Furthermore, there are detailing tips, tricks pitfalls avoid. All written peer‐reviewed by leading experts immunologists, making an essential state‐of‐the‐art handbook for basic researchers.

Language: Английский

---

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(9), P. 995 - 1003

Published: July 31, 2017

Language: Английский

---