Regulation of hepatic glucose metabolism in health and disease

Nature Reviews Endocrinology, Journal Year: 2017, Volume and Issue: 13(10), P. 572 - 587

Published: July 21, 2017

Language: Английский

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Metabolic Flexibility in Health and Disease

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(5), P. 1027 - 1036

Published: May 1, 2017

Language: Английский

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Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis

Psychoneuroendocrinology, Journal Year: 2017, Volume and Issue: 83, P. 25 - 41

Published: May 24, 2017

Language: Английский

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The human stress response

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(9), P. 525 - 534

Published: June 27, 2019

Language: Английский

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Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

Cell Metabolism, Journal Year: 2018, Volume and Issue: 29(2), P. 303 - 319.e4

Published: Aug. 30, 2018

Language: Английский

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Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2018, Volume and Issue: unknown

Published: Oct. 19, 2018

Summary While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear. To identify these effects, we performed cis- and trans-expression quantitative trait locus (eQTL) analysis in blood from 31,684 individuals the eQTLGen Consortium. We observed that cis -eQTLs can be detected for 88% of studied genes, but they a different genetic architecture compared to variants, limiting our ability use pinpoint causal genes within susceptibility loci. In contrast, trans-eQTLs (detected 37% 10,317 trait-associated variants) were more informative. Multiple unlinked associated same complex trait, often converged on trans-genes are known play central roles disease etiology. when ascertaining effect polygenic scores calculated 1,263 study (GWAS) traits. Expression levels 13% correlated with scores, resulting drive

Language: Английский

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Clocking in to immunity

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(7), P. 423 - 437

Published: April 16, 2018

Language: Английский

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Circadian Mechanisms in Medicine

New England Journal of Medicine, Journal Year: 2021, Volume and Issue: 384(6), P. 550 - 561

Published: Feb. 10, 2021

Molecular insights into diurnal variations in human physiology and behavior are extending our understanding of a wide range disease processes. Chronobiology is also providing testable hypotheses regarding the timing treatments.

Language: Английский

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Circadian clock genes and the transcriptional architecture of the clock mechanism

Journal of Molecular Endocrinology, Journal Year: 2019, Volume and Issue: 63(4), P. R93 - R102

Published: Sept. 26, 2019

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with of organism (such eating and sleeping) helps different tissue organ systems coordinate optimize their performance. full extent mechanisms by which cells maintain are still under investigation, but involve a core set genes that regulate large networks gene transcription both direct transcriptional activation/repression well recruitment proteins modify chromatin states more broadly.

Language: Английский

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Medicine in the Fourth Dimension

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(2), P. 238 - 250

Published: Aug. 1, 2019

Language: Английский

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