Functional Classification and Experimental Dissection of Long Noncoding RNAs

Cell, Journal Year: 2018, Volume and Issue: 172(3), P. 393 - 407

Published: Jan. 1, 2018

Language: Английский

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The Biogenesis, Functions, and Challenges of Circular RNAs

Molecular Cell, Journal Year: 2018, Volume and Issue: 71(3), P. 428 - 442

Published: July 26, 2018

Language: Английский

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Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Jan. 3, 2020

Abstract Based on engineered or bacterial nucleases, the development of genome editing technologies has opened up possibility directly targeting and modifying genomic sequences in almost all eukaryotic cells. Genome extended our ability to elucidate contribution genetics disease by promoting creation more accurate cellular animal models pathological processes begun show extraordinary potential a variety fields, ranging from basic research applied biotechnology biomedical research. Recent progress developing programmable such as zinc-finger nucleases (ZFNs), transcription activator-like effector (TALENs) clustered regularly interspaced short palindromic repeat (CRISPR)–Cas-associated greatly expedited gene concept clinical practice. Here, we review recent advances three major (ZFNs, TALENs, CRISPR/Cas9) discuss applications their derivative reagents tools various human diseases future therapies, focusing cells models. Finally, provide an overview trials applying platforms for treatment some challenges implementation this technology.

Language: Английский

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Cellular functions of long noncoding RNAs

Nature Cell Biology, Journal Year: 2019, Volume and Issue: 21(5), P. 542 - 551

Published: May 1, 2019

Language: Английский

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The next generation of CRISPR–Cas technologies and applications

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(8), P. 490 - 507

Published: May 30, 2019

Language: Английский

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The functions and unique features of long intergenic non-coding RNA

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 19(3), P. 143 - 157

Published: Nov. 15, 2017

Language: Английский

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Long non-coding RNAs: definitions, functions, challenges and recommendations

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(6), P. 430 - 447

Published: Jan. 3, 2023

Language: Английский

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Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Nature Genetics, Journal Year: 2019, Volume and Issue: 51(12), P. 1664 - 1669

Published: Nov. 29, 2019

Language: Английский

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Opportunities and challenges for transcriptome-wide association studies

Nature Genetics, Journal Year: 2019, Volume and Issue: 51(4), P. 592 - 599

Published: March 29, 2019

Language: Английский

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How do lncRNAs regulate transcription?

Science Advances, Journal Year: 2017, Volume and Issue: 3(9)

Published: Sept. 1, 2017

It has recently become apparent that RNA, itself the product of transcription, is a major regulator transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function many cases as regulators. These through binding to histone-modifying complexes, DNA proteins (including transcription factors), and even RNA polymerase II. other cases, it act lncRNA rather than appears be regulatory. We review recent progress elucidating molecular mechanisms by lncRNAs modulate gene expression future opportunities this research field.

Language: Английский

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