Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Immunity, Journal Year: 2019, Volume and Issue: 51(1), P. 27 - 41

Published: July 1, 2019

Language: Английский

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Microbiota in health and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: April 23, 2022

Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.

Language: Английский

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Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

Cell, Journal Year: 2021, Volume and Issue: 184(21), P. 5309 - 5337

Published: Oct. 1, 2021

Language: Английский

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Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(6), P. 968 - 976

Published: June 1, 2019

Language: Английский

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Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 16(11), P. 690 - 704

Published: Sept. 25, 2019

Language: Английский

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The microbiome, cancer, and cancer therapy

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(3), P. 377 - 388

Published: March 1, 2019

Language: Английский

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Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Annals of Oncology, Journal Year: 2020, Volume and Issue: 31(10), P. 1291 - 1305

Published: July 20, 2020

Language: Английский

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The updated landscape of tumor microenvironment and drug repurposing

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Aug. 25, 2020

Abstract Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram initiation, growth, invasion, metastasis, response to therapies. Cancer research treatment have switched from a cancer-centric model TME-centric one, considering the increasing significance of TME cancer biology. Nonetheless, clinical efficacy therapeutic strategies targeting TME, especially specific cells or pathways remains unsatisfactory. Classifying chemopathological characteristics crosstalk among one another greatly benefit further studies exploring effective treating methods. Herein, we present an updated image with emphasis on hypoxic niche, immune microenvironment, metabolism acidic innervated mechanical microenvironment. We then summarize conventional drugs including aspirin, celecoxib, β-adrenergic antagonist, metformin, statin new antitumor application. These are considered as viable candidates for combination therapy due their activity extensive use practice. also provide our outlook directions potential applications theory. This review depicts comprehensive vivid landscape biology treatment.

Language: Английский

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Fusobacterium nucleatum — symbiont, opportunist and oncobacterium

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 17(3), P. 156 - 166

Published: Dec. 13, 2018

Language: Английский

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The microbiome and human cancer

Science, Journal Year: 2021, Volume and Issue: 371(6536)

Published: March 25, 2021

Microbial roles in cancer formation, diagnosis, prognosis, and treatment have been disputed for centuries. Recent studies provocatively claimed that bacteria, viruses, and/or fungi are pervasive among cancers, key actors immunotherapy, engineerable to treat metastases. Despite these findings, the number of microbes known directly cause carcinogenesis remains small. Critically evaluating building frameworks such evidence light modern biology is an important task. In this Review, we delineate between causal complicit trace common themes their influence through host's immune system, herein defined as immuno-oncology-microbiome axis. We further review intratumoral approaches manipulate gut or tumor microbiome while projecting next phase experimental discovery.

Language: Английский

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