RETRACTED ARTICLE: Microbiome analyses of blood and tissues suggest cancer diagnostic approach

Nature, Journal Year: 2020, Volume and Issue: 579(7800), P. 567 - 574

Published: March 11, 2020

Language: Английский

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Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Nature, Journal Year: 2020, Volume and Issue: 580(7802), P. 269 - 273

Published: Feb. 27, 2020

Language: Английский

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Bacterial Biofilm and its Role in the Pathogenesis of Disease

Antibiotics, Journal Year: 2020, Volume and Issue: 9(2), P. 59 - 59

Published: Feb. 3, 2020

Recognition of the fact that bacterial biofilm may play a role in pathogenesis disease has led to an increased focus on identifying diseases be biofilm-related. Biofilm infections are typically chronic nature, as biofilm-residing bacteria can resilient both immune system, antibiotics, and other treatments. This is comprehensive review describing auditory, cardiovascular, digestive, integumentary, reproductive, respiratory, urinary system. In most cases reviewed, biofilms were identified through various imaging technics, addition study approaches. The current knowledge how contribute indicates number different mechanisms. spans from being mere reservoir pathogenic bacteria, playing more active role, e.g., by contributing inflammation. Observations also indicate does not exclusively occur extracellularly, but formed inside living cells. Furthermore, presence development cancer. conclusion, this shows part many, probably infections. important for effective treatment strategies such

Language: Английский

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Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

Cell, Journal Year: 2019, Volume and Issue: 176(5), P. 998 - 1013.e16

Published: Jan. 31, 2019

Language: Английский

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Targeting metastatic cancer

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(1), P. 34 - 44

Published: Jan. 1, 2021

Language: Английский

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The Intestinal Microbiota in Colorectal Cancer

Cancer Cell, Journal Year: 2018, Volume and Issue: 33(6), P. 954 - 964

Published: April 12, 2018

Language: Английский

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The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

Science, Journal Year: 2018, Volume and Issue: 359(6382), P. 1366 - 1370

Published: March 22, 2018

The fine line between human health and disease can be driven by the interplay host microbial factors. This “metagenome” regulates cancer initiation, progression, response to therapies. Besides capacity of distinct species modulate pharmacodynamics chemotherapeutic drugs, symbiosis epithelial barriers their ecosystems has a major impact on local distant immune system, markedly influencing clinical outcome in patients. Efficacy immunotherapy with checkpoint antibodies diminished administration antibiotics, superior efficacy is observed presence specific gut microbes. Future strategies precision medicine will likely rely novel diagnostic therapeutic tools which identify correct defects microbiome that compromise efficacy.

Language: Английский

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Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Gastroenterology, Journal Year: 2019, Volume and Issue: 158(2), P. 322 - 340

Published: Oct. 3, 2019

Language: Английский

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Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer

Cell, Journal Year: 2022, Volume and Issue: 185(8), P. 1356 - 1372.e26

Published: April 1, 2022

Language: Английский

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Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

Oncogene, Journal Year: 2020, Volume and Issue: 39(26), P. 4925 - 4943

Published: June 8, 2020

Abstract Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field study. Gut microbiota modulation, with aim to reverse established microbial dysbiosis, novel strategy for prevention and treatment CRC. Different strategies including probiotics, prebiotics, postbiotics, antibiotics, fecal transplantation (FMT) have been employed. Although these show promising results, mechanistically by correcting composition, modulating innate immune system, enhancing barrier function, preventing pathogen colonization exerting selective cytotoxicity against tumor cells, it should be noted that they are accompanied risks controversies can potentially introduce clinical complications. During bench-to-bedside translation, evaluation risk-and-benefit ratio, as well patient selection, carefully performed. In view individualized host response intervention, developing personalized therapy may key successful treatment.

Language: Английский

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