Microorganisms,
Journal Year:
2018,
Volume and Issue:
6(3), P. 75 - 75
Published: July 23, 2018
Akkermansia
muciniphila
is
a
mucin-degrading
bacterium
of
the
phylum
Verrucomicrobia.
Its
abundance
in
human
intestinal
tract
inversely
correlated
to
several
disease
states.
A.
resides
mucus
layer
large
intestine,
where
it
involved
maintaining
integrity.
We
explore
presence
Akkermansia-like
spp.
based
on
its
16S
rRNA
sequence
and
metagenomic
signatures
body
so
as
understand
colonization
pattern
time
space.
were
detected
colonic
samples
early
few
weeks
after
birth
likely
could
be
maintained
throughout
life.
The
sites
sequences
(including
Verrucomicrobia
and/or
found
literature)
apart
from
colon
included
milk,
oral
cavity,
pancreas,
biliary
system,
small
appendix.
function
these
may
differ
that
mucosal
colon.
present
appendix
or
milk
play
role
re-colonization
breast-fed
infants,
respectively.
In
conclusion,
even
though
most
abundantly
colon,
along
digestive
indicates
this
might
have
more
functions
than
those
currently
known.
Cell,
Journal Year:
2019,
Volume and Issue:
176(3), P. 649 - 662.e20
Published: Jan. 1, 2019
The
body-wide
human
microbiome
plays
a
role
in
health,
but
its
full
diversity
remains
uncharacterized,
particularly
outside
of
the
gut
and
international
populations.
We
leveraged
9,428
metagenomes
to
reconstruct
154,723
microbial
genomes
(45%
high
quality)
spanning
body
sites,
ages,
countries,
lifestyles.
recapitulated
4,930
species-level
genome
bins
(SGBs),
77%
without
public
repositories
(unknown
SGBs
[uSGBs]).
uSGBs
are
prevalent
(in
93%
well-assembled
samples),
expand
underrepresented
phyla,
enriched
non-Westernized
populations
(40%
total
SGBs).
annotated
2.85
M
genes
SGBs,
many
associated
with
conditions
including
infant
development
(94,000)
or
Westernization
(106,000).
permit
deeper
analyses
increase
average
mappability
metagenomic
reads
from
67.76%
87.51%
(median
94.26%)
65.14%
82.34%
mouth.
thus
identify
thousands
yet-to-be-named
species,
pangenomes
human-associated
microbes,
allow
better
exploitation
technologies.
Science,
Journal Year:
2018,
Volume and Issue:
362(6416), P. 776 - 780
Published: Nov. 15, 2018
Diet
affects
multiple
facets
of
human
health
and
is
inextricably
linked
to
chronic
metabolic
conditions
such
as
obesity,
type
2
diabetes,
cardiovascular
disease.
Dietary
nutrients
are
essential
not
only
for
but
also
the
survival
trillions
microbes
that
reside
within
intestines.
a
key
component
relationship
between
humans
their
microbial
residents;
gut
use
ingested
fundamental
biological
processes,
outputs
those
processes
may
have
important
impacts
on
physiology.
Studies
in
animal
models
beginning
unravel
underpinnings
this
relationship,
increasing
evidence
suggests
it
underlie
some
broader
effects
diet
mSystems,
Journal Year:
2018,
Volume and Issue:
3(3)
Published: May 14, 2018
Although
much
work
has
linked
the
human
microbiome
to
specific
phenotypes
and
lifestyle
variables,
data
from
different
projects
have
been
challenging
integrate
extent
of
microbial
molecular
diversity
in
stool
remains
unknown.
Using
standardized
protocols
Earth
Microbiome
Project
sample
contributions
over
10,000
citizen-scientists,
together
with
an
open
research
network,
we
compare
specimens
primarily
United
States,
Kingdom,
Australia
one
another
environmental
samples.
Our
results
show
unexpected
range
beta-diversity
microbiomes
compared
samples;
demonstrate
utility
procedures
for
removing
effects
overgrowth
during
room-temperature
shipping
revealing
phenotype
correlations;
uncover
new
molecules
kinds
communities
metabolome;
examine
emergent
associations
among
microbiome,
metabolome,
plants
that
are
consumed
(rather
than
relying
on
reductive
categorical
variables
such
as
veganism,
which
little
or
no
explanatory
power).
We
also
living
resource
cross-cohort
comparison
confirm
existing
between
psychiatric
illness
reveal
change
within
individual
surgery,
providing
a
paradigm
education.
IMPORTANCE
citizen
science,
self-selected
cohort
samples
through
mail
at
room
temperature
recaptures
many
known
clinically
collected
cohorts
reveals
ones.
Of
particular
interest
is
integrating
n
=
1
study
population
data,
showing
after
events
surgery
can
exceed
differences
distinct
biomes,
effect
diverse
diet,
untargeted
metabolomics
hundreds
