Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

Science, Journal Year: 2018, Volume and Issue: 362(6416)

Published: Nov. 1, 2018

Mapping the brain, one neuron at a time Spatial transcriptomics can link molecularly described cell types to their anatomical positions and functional roles. Moffitt et al. used combination of single-cell RNA-sequencing MERFISH (multiplexed error-robust fluorescence in situ hybridization) map identity location specific within mouse preoptic hypothalamus surrounding areas brain (see Perspective by Tasic Nicovich). They related these behaviors via gene activity. The approach provides an unbiased description area, which are important for sleep, thermoregulation, thirst, social behavior. Science , this issue p. eaau5324 ; see also 749

Language: Английский

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Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

Cell, Journal Year: 2018, Volume and Issue: 174(1), P. 59 - 71.e14

Published: May 24, 2018

Language: Английский

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Temporal evolution of cortical ensembles promoting remote memory retrieval

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(3), P. 460 - 469

Published: Jan. 12, 2019

Language: Английский

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Genetic Dissection of Neural Circuits: A Decade of Progress

Neuron, Journal Year: 2018, Volume and Issue: 98(2), P. 256 - 281

Published: April 1, 2018

Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have carried out in a multitude invertebrate vertebrate organisms, linking neurons to behavioral functions. New methods allow systematic classification cell types provide access diverse neuronal for connectivity coding during behavior. Here we evaluate key advances over the past decade discuss future directions.

Language: Английский

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Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems

Cell, Journal Year: 2018, Volume and Issue: 175(2), P. 472 - 487.e20

Published: Aug. 23, 2018

Language: Английский

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Thirst regulates motivated behavior through modulation of brainwide neural population dynamics

Science, Journal Year: 2019, Volume and Issue: 364(6437)

Published: April 19, 2019

Neuron activity across the brain How is it that groups of neurons dispersed through interact to generate complex behaviors? Three papers in this issue present brain-scale studies neuronal and dynamics (see Perspective by Huk Hart). Allen et al. found thirsty mice, there widespread neural related stimuli elicit licking drinking. Individual encoded task-specific responses, but every area contained with different types response. Optogenetic stimulation thirst-sensing one reinstated drinking previously signaled thirst. Gründemann investigated mouse basal amygdala relation behavior during tasks. Two ensembles showed orthogonal exploratory nonexploratory behaviors, possibly reflecting levels anxiety experienced these areas. Stringer analyzed spontaneous firing, finding primary visual cortex both information motor facial movements. The variability responses mainly arousal reflects encoding latent behavioral states. Science , p. eaav3932 eaav8736 eaav7893 ; see also 236

Language: Английский

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An evolutionary perspective on immunometabolism

Science, Journal Year: 2019, Volume and Issue: 363(6423)

Published: Jan. 11, 2019

Metabolism as a driver of immune response All living organisms need energy and metabolic building blocks to sustain biological processes. Wang et al. review immunometabolism, applying the principles life history theory. They highlight recent advances showing reciprocal interactions between systemic metabolism immunity, well how inflammation can alter functional state organs their central control by hypothalamus. Such coordinated cross-talk whole-body cell is involved in variety health disease states. Science , this issue p. eaar3932

Language: Английский

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Microbiota modulate sympathetic neurons via a gut–brain circuit

Nature, Journal Year: 2020, Volume and Issue: 583(7816), P. 441 - 446

Published: July 8, 2020

Language: Английский

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Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia

Science, Journal Year: 2021, Volume and Issue: 371(6525), P. 153 - 159

Published: Jan. 7, 2021

Social transmission of pain and relief In mice, both fear can be transferred by short social contact from one animal to a bystander. Neurons in brain region called the anterior cingulate cortex bystander mediate these transfers. However, specific projections involved such empathy-related behaviors are unknown. Smith et al. found that nucleus accumbens necessary for transfer mice (see Perspective Klein Gogolla). Fear, however, was mediated basolateral amygdala. Interestingly, animals with pain, analgesia also socially. Science , this issue p. 153 ; see 122

Language: Английский

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A neuronal circuit for activating descending modulation of neuropathic pain

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(10), P. 1659 - 1668

Published: Sept. 9, 2019

Language: Английский

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