Searching for the Metaverse: Neuroscience of Physical and Digital Communities DOI Creative Commons
Giuseppe Riva, Brenda K. Wiederhold, Fabrizia Mantovani

et al.

Cyberpsychology Behavior and Social Networking, Journal Year: 2023, Volume and Issue: 27(1), P. 9 - 18

Published: April 14, 2023

What distinguishes real-world communities from their online counterparts? Social and cognitive neuroscience research on social networks collective intentionality will be used in the article to answer this question. Physical are born places. And places engage "we-mode" neurobiological processes as behavioral synchrony, shared attention, deliberate attunement, interbrain synchronization, so on, which create coherent of very different individuals who supported by a "wisdom crowd." Digital technologies remove physical boundaries, giving people more freedom choose activities groups. At same time, however, lack co-presence community members significantly reduces possibility activating motivation. Because this, unlike that allow interaction between varied origins stories, digital always made up have interests knowledge (communities practice). This new situation disrupts crowd," making radical less accurate (polarization effect), allowing influential users wield disproportionate influence over group's beliefs, producing inequalities distribution capital. However, emergent technology-the Metaverse-has potential reverse trend. Several studies revealed virtual augmented reality-the major underlying Metaverse-can environments. If many flaws technology fixed, it might encourage meaningful constructive interactions communities.

Language: Английский

Brain circuits for pain and its treatment DOI
Nicole Mercer Lindsay, Chong Chen, Gadi Gilam

et al.

Science Translational Medicine, Journal Year: 2021, Volume and Issue: 13(619)

Published: Nov. 10, 2021

Understanding the organization of brain’s pain circuits is critical for developing effective treatments patients suffering from chronic pain.

Language: Английский

Citations

146

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications DOI Creative Commons

Chen-Chen Jiang,

Lishan Lin,

Sen Long

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 11, 2022

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental which has strong genetic basis. Despite the rapidly rising incidence of autism, little known about its aetiology, risk factors, disease progression. There are currently neither validated biomarkers for diagnostic screening nor specific medication autism. Over last two decades, there have been remarkable advances in genetics, with hundreds genes identified as being associated high The convergence neuroscience methods becoming more widely recognized significance elucidating pathological mechanisms Efforts devoted to exploring behavioural functions, key potential treatments Here, we highlight this review, emerging evidence shows that signal transduction molecular events involved processes such transcription, translation, synaptic transmission, epigenetics immunoinflammatory responses. This involvement important implications discovery precise targets Moreover, review recent insights into clinical autism from molecular, cellular, neural circuit, neurobehavioural aspects. Finally, challenges future perspectives discussed regard novel strategies predicated on biological features

Language: Английский

Citations

130

Innovations and advances in modelling and measuring pain in animals DOI
Katelyn E. Sadler, Jeffrey S. Mogil, Cheryl L. Stucky

et al.

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 23(2), P. 70 - 85

Published: Nov. 26, 2021

Language: Английский

Citations

118

Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain DOI Creative Commons
Mingming Zhang,

Anqi Geng,

Kun Chen

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(12), P. 1993 - 2008.e6

Published: April 19, 2022

Language: Английский

Citations

102

Emotional contagion and prosocial behavior in rodents DOI Creative Commons
Christian Keysers, Ewelina Knapska, Marta A. Moita

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(8), P. 688 - 706

Published: June 3, 2022

Empathy is critical to adjusting our behavior the state of others. The past decade dramatically deepened understanding biological origin this capacity. We now understand that rodents robustly show emotional contagion for distress others via neural structures homologous those involved in human empathy. Their propensity approach strengthens effect. Although can also learn favor behaviors benefit overlapping with contagion, they do so less reliably and more selectively. Together, suggests evolution selected mechanisms prepare animals dangers by using as sentinels. Such shared emotions additionally can, under certain circumstances, promote prosocial behavior.

Language: Английский

Citations

90

Sound induces analgesia through corticothalamic circuits DOI Open Access
Wenjie Zhou, Chonghuan Ye, Haitao Wang

et al.

Science, Journal Year: 2022, Volume and Issue: 377(6602), P. 198 - 204

Published: July 7, 2022

Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise mice. Viral tracing, microendoscopic calcium imaging, multitetrode recordings freely moving mice showed low-SNR sounds inhibited glutamatergic inputs from auditory cortex (ACxGlu) thalamic posterior (PO) ventral (VP) nuclei. Optogenetic or chemogenetic inhibition ACxGlu→PO ACxGlu→VP circuits mimicked sound-induced analgesia inflamed hindpaws forepaws, respectively. Artificial activation these two abolished analgesia. Our study reveals corticothalamic sound-promoted by deciphering role system processing.

Language: Английский

Citations

73

Hippocampal-amygdala memory circuits govern experience-dependent observational fear DOI Creative Commons
Joseph I. Terranova, Jun Yokose, Hisayuki Osanai

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(8), P. 1416 - 1431.e13

Published: Feb. 8, 2022

The empathic ability to vicariously experience the other's fearful situation, a process called observational fear (OF), is critical survive in nature and function society. OF can be facilitated by both prior similar observer social familiarity with demonstrator. However, neural circuit mechanisms of experience-dependent (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits mice without involving anterior cingulate cortex, considered center OF, mediate Exp OF. Dorsal HPC neurons generate memory engram cells BLA encoding experiences, which are essential for On other hand, ventral respond familiar demonstrator's aversive situation during reactivates elicit Our study provides new insights into engram-dependent perception-action coupling underlies behaviors like

Language: Английский

Citations

71

Social circuits and their dysfunction in autism spectrum disorder DOI Creative Commons
Masaaki Sato, Nobuhiro Nakai,

Shuhei Fujima

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(8), P. 3194 - 3206

Published: Aug. 1, 2023

Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social many different behavioral paradigms have been used for investigating their neural circuit bases. behavior is highly vulnerable to brain network dysfunction caused by neurological neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms abnormal potential therapeutic targets treatment. In this review, we outline recent progress key findings on underlying behavior, particular emphasis rodent studies that monitor manipulate the activity specific circuits using modern systems neuroscience approaches. mediated distributed brain-wide among major cortical (e.g., medial prefrontal cortex (mPFC), anterior cingulate cortex, insular (IC)) subcortical nucleus accumbens, basolateral amygdala (BLA), ventral tegmental area) structures, influenced multiple neuromodulatory oxytocin, dopamine, serotonin). We particularly draw special attention IC unique area mediates multisensory integration, encoding ongoing interaction, decision-making, emotion, empathy. Additionally, synthesis demonstrates dysfunctions in mPFC-BLA circuitry neuromodulation prominent. Pharmacological rescues local or systemic oral) administration drugs provided valuable clues developing new agents ASD. Future efforts technological advances will push forward next frontiers field, elucidation inter-brain dynamics during real virtual interactions, establishment circuit-based therapy affecting functions.

Language: Английский

Citations

50

An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences DOI
Qian Song, Anqi Wei, Hua‐Dong Xu

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(2), P. 272 - 285

Published: Jan. 3, 2024

Language: Английский

Citations

38

Cortical regulation of helping behaviour towards others in pain DOI
Mingmin Zhang, Ye Wu,

Mengping Jiang

et al.

Nature, Journal Year: 2024, Volume and Issue: 626(7997), P. 136 - 144

Published: Jan. 24, 2024

Language: Английский

Citations

31