An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials

Advanced Science, Journal Year: 2020, Volume and Issue: 7(21)

Published: Sept. 24, 2020

Abstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used make hydrogels by conventional methods such as freeze–thaw chemical crosslinking, but formidable produce strong materials adjustable properties. Herein, a method induce crystallinity physically crosslinked PVA via applying high‐concentration sodium hydroxide into dense polymer introduced. Such strategy enables the production of biomaterial high mechanical properties, low water content, resistance injury, It also found that developed hydrogel recover 90% plastic deformation due extension upon supplying water, providing contraction force sufficiently lift objects 1100 times more than their weight. Cytocompatibility, antifouling property, hemocompatibility, biocompatibility are demonstrated vitro vivo. The fabrication PVA‐based catheters, injectable electronics, microfluidic devices demonstrated. This gelation approach both layer‐by‐layer 3D printing fabrications.

Language: Английский

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Nanowired Bioelectric Interfaces

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(15), P. 9136 - 9152

Published: April 17, 2019

Biological systems have evolved biochemical, electrical, mechanical, and genetic networks to perform essential functions across various length time scales. High-aspect-ratio biological nanowires, such as bacterial pili neurites, mediate many of the interactions homeostasis in between these networks. Synthetic materials designed mimic structure nanowires could also incorporate similar functional properties, exploiting this structure–function relationship has already proved fruitful designing biointerfaces. Semiconductor are a particularly promising class synthetic for biointerfaces, given (1) their unique optical electronic properties (2) high degree control versatility. These characteristics enable fabrication variety photonic nanowire devices, allowing formation well-defined, bioelectric interfaces at biomolecular level whole-organ level. In Focus Review, we first discuss history with semiconductor nanowires. We next highlight several important, endogenous use framework categorize nanowire-based Within then review fundamentals comment on both material choice device design form biointerfaces spanning multiple conclude discussion areas potential greatest impact using nanowire-enabled future.

Language: Английский

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Injectable biomaterials for translational medicine

Materials Today, Journal Year: 2019, Volume and Issue: 28, P. 81 - 97

Published: May 21, 2019

Injectable therapeutics enabled by engineered biomaterials are becoming increasingly popular, transforming traditional clinical practice to become a minimally invasive and regenerative regime. Compared preformed biomaterials, injectable allow for more precise implantation into deeply enclosed anatomical locations the repair of irregularly shaped lesions, demonstrating great translational potential. Continuously emerging needs advances in materials science have driven an evolution from structural fillers multifunctional platforms. Integrating disparate functions design translation remains considerable challenge, as does selection appropriate considerations specific applications. This article aims review fabrication context medical translation, engineering strategies used new meet growing demands intelligent medicine, progress their development selected Specifically, three exemplary areas, bone cements, hydrogels, electronics, all which demonstrate significant promise terms commercialization, reviewed detail. In addition, status future challenges discussed. It is also envisioned that mutual collaboration between researchers, clinicians, entrepreneurs, engineers, patients will inspire catalyze innovation biomaterials.

Language: Английский

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Recent Advances in Electrical Neural Interface Engineering: Minimal Invasiveness, Longevity, and Scalability

Neuron, Journal Year: 2020, Volume and Issue: 108(2), P. 302 - 321

Published: Oct. 1, 2020

Language: Английский

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Flexible Electrodes for In Vivo and In Vitro Electrophysiological Signal Recording

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(17)

Published: May 29, 2021

Abstract A variety of electrophysiological signals (electrocardiography, electromyography, electroencephalography, etc.) are generated during the physiological activities human bodies, which can be collected by electrodes and thus provide critical insights into health status or facilitate fundamental scientific research. The long‐term stable high‐quality recording is premise for their further applications, leading to demands flexible with similar mechanical modulus minimized irritation bodies. This review summarizes latest advances in acquisition various signals. First, concept characteristics different subcategory introduced. Second, invasive noninvasive methods reviewed signal a highlight on design electrodes, followed discussion material selection. Subsequently, applications pathological diagnosis restoration body functions discussed, showing advantages electrodes. Finally, main challenges opportunities this field discussed. It believed that exploration materials combination multidisciplinary technologies will boost medical human–machine interface.

Language: Английский

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