Molecular mechanisms and physiological importance of circadian rhythms

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 21(2), P. 67 - 84

Published: Nov. 25, 2019

Language: Английский

---

Circadian control of brain glymphatic and lymphatic fluid flow

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 2, 2020

The glymphatic system is a network of perivascular spaces that promotes movement cerebrospinal fluid (CSF) into the brain and clearance metabolic waste. This transport supported by water channel aquaporin-4 (AQP4) localized to vascular endfeet astrocytes. more effective during sleep, but whether sleep timing function remains unknown. We here show influx exhibit endogenous, circadian rhythms peaking mid-rest phase mice. Drainage CSF from cisterna magna lymph nodes exhibits daily variation opposite influx, suggesting distribution throughout animal depends on time-of-day. polarization AQP4 highest rest loss eliminates day-night difference in both drainage nodes. conclude under control supports this rhythm.

Language: Английский

---

Genomics of circadian rhythms in health and disease

Genome Medicine, Journal Year: 2019, Volume and Issue: 11(1)

Published: Dec. 1, 2019

Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts over myriad aspects of mammalian physiology, including the regulation sleep, metabolism, immune system. Here, we review advances in understanding genetic sleep through system, as well impact dysregulated gene expression on metabolic function. We also recent studies have begun to unravel clock’s role controlling cardiovascular nervous systems, gut microbiota, cancer, aging. Such these systems relies, part, transcriptional regulation, with evidence for genome-wide chromosome organization. These novel insights into genomic human physiology provide opportunities discovery improved treatment strategies new biological underpinnings disease.

Language: Английский

---

Circadian clock genes and the transcriptional architecture of the clock mechanism

Journal of Molecular Endocrinology, Journal Year: 2019, Volume and Issue: 63(4), P. R93 - R102

Published: Sept. 26, 2019

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with of organism (such eating and sleeping) helps different tissue organ systems coordinate optimize their performance. full extent mechanisms by which cells maintain are still under investigation, but involve a core set genes that regulate large networks gene transcription both direct transcriptional activation/repression well recruitment proteins modify chromatin states more broadly.

Language: Английский

---

Astrocyte morphology: Diversity, plasticity, and role in neurological diseases

CNS Neuroscience & Therapeutics, Journal Year: 2019, Volume and Issue: 25(6), P. 665 - 673

Published: March 30, 2019

Summary Astrocytes are the most abundant glial cells in central nervous system (CNS) and participate synaptic, circuit, behavioral functions. The well‐developed protoplasmic astrocytes contain numerous processes forming well‐delineated bushy territories that overlap by as little 5% at their boundaries. This highly complex morphology, with up to approximately 80% of cell's membrane constituted fine dimensions on tens nanometer scale high surface area volume ratios, comes contact synapses, blood vessels, other cells. Recent progress is challenging conventional view morphologically homogeneous throughout brain; instead, they display circuit‐ region‐specific morphological diversity may contribute heterogeneous astrocyte‐neuron spatiotemporal interplay different brain areas. Further, structure found be plastic activity‐dependent. We beginning understand how astrocyte structural plasticity contributes change/loss traditionally known a hallmark for reactive astrogliosis, common pathological feature many neurological disorders. However, recent data suggest deficits preceding astrogliosis drive disease progression. review summarizes advances diversity, plasticity, disease‐related deficits.

Language: Английский

---

Medicine in the Fourth Dimension

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(2), P. 238 - 250

Published: Aug. 1, 2019

Language: Английский

---

Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(3), P. 456 - 467

Published: Feb. 17, 2020

Language: Английский

---

Behaviorally consequential astrocytic regulation of neural circuits

Neuron, Journal Year: 2020, Volume and Issue: 109(4), P. 576 - 596

Published: Dec. 31, 2020

Language: Английский

---

Communicating clocks shape circadian homeostasis

Science, Journal Year: 2021, Volume and Issue: 371(6530)

Published: Feb. 11, 2021

Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951

Language: Английский

---

Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease

Trends in Cell Biology, Journal Year: 2019, Volume and Issue: 30(2), P. 133 - 143

Published: Dec. 23, 2019

Language: Английский

---