Locus coeruleus: a new look at the blue spot

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(11), P. 644 - 659

Published: Sept. 17, 2020

Language: Английский

---

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Nature Methods, Journal Year: 2020, Volume and Issue: 17(11), P. 1156 - 1166

Published: Oct. 21, 2020

Language: Английский

---

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Nature Methods, Journal Year: 2020, Volume and Issue: 17(11), P. 1139 - 1146

Published: Sept. 28, 2020

Language: Английский

---

Improved tools to study astrocytes

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 121 - 138

Published: Feb. 10, 2020

Language: Английский

---

A genetically encoded sensor for measuring serotonin dynamics

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(5), P. 746 - 752

Published: April 5, 2021

Language: Английский

---

Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 206, P. 115 - 147

Published: Feb. 26, 2022

Thanks to their unique attributes, such as good sensitivity, selectivity, high surface-to-volume ratio, and versatile optical electronic properties, fluorescent-based bioprobes have been used create highly sensitive nanobiosensors detect various biological chemical agents. These sensors are superior other analytical instrumentation techniques like gas chromatography, high-performance liquid capillary electrophoresis for being biodegradable, eco-friendly, more economical, operational, cost-effective. Moreover, several reports also highlighted application in the early detection of biomarkers associated with drug-induced organ damage liver, kidney, or lungs. In present work, we comprehensively overviewed electrochemical that employ nanomaterials (nanoparticles/colloids quantum dots, carbon nanoscaled metal-organic frameworks, etc.) a variety macromolecules based on fluorescent emission spectra. addition, most important mechanisms methods sense amino acids, protein, peptides, enzymes, carbohydrates, neurotransmitters, nucleic vitamins, ions, metals, electrolytes, blood gases, drugs (i.e., anti-inflammatory agents antibiotics), toxins, alkaloids, antioxidants, cancer biomarkers, urinary metabolites urea, uric acid, creatinine), pathogenic microorganisms were outlined compared terms selectivity sensitivity. Altogether, small dimensions capability these nanosensors sensitive, label-free, real-time sensing chemical, biological, pharmaceutical could be array-based screening in-vitro in-vivo diagnostics. Although nanoprobes widely applied determining macromolecules, unfortunately, they many challenges limitations. Efforts must made minimize limitations utilizing an emphasis commercial developments. We believe current review can foster wider incorporation nanomedicine will particular interest researchers working fluorescence technology, material chemistry, coordination polymers, related research areas.

Language: Английский

---

Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons

Science, Journal Year: 2020, Volume and Issue: 369(6508)

Published: Sept. 3, 2020

Sleep and wakefulness are homeostatically regulated by a variety of factors, including adenosine. However, how neural activity underlying the sleep-wake cycle controls adenosine release in brain remains unclear. Using newly developed genetically encoded sensor, we found an activity-dependent rapid increase concentration extracellular mouse basal forebrain (BF), critical region controlling sleep wakefulness. Although both BF cholinergic glutamatergic neurons correlated with changes adenosine, optogenetic activation these at physiological firing frequencies showed that contributed much more to increase. Mice selective ablation exhibited reduced impaired homeostasis regulation. Thus, cell type-specific dynamically homeostasis.

Language: Английский

---

Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture

Journal of Neuroscience, Journal Year: 2019, Volume and Issue: 39(42), P. 8239 - 8249

Published: Oct. 16, 2019

The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that prominent component of disparate theories brain function due to its broad noradrenergic projections throughout the CNS. As diffuse system, noradrenaline affects learning decision making, control sleep wakefulness, sensory salience including pain, physiology correlated forebrain activity (ensembles networks) hemodynamic responses. However, our understanding LC undergoing dramatic shift application state-of-the-art methods reveal many modules provide targeted neuromodulation. Here, we review evidence supporting modular based on multiple levels observation (developmental, genetic, molecular, anatomical, neurophysiological). We suggest concept as and, alongside it, role in diverse must be reconsidered.

Language: Английский

---

An expanded palette of dopamine sensors for multiplex imaging in vivo

Nature Methods, Journal Year: 2020, Volume and Issue: 17(11), P. 1147 - 1155

Published: Sept. 7, 2020

Language: Английский

---

Structure- and mechanism-guided design of single fluorescent protein-based biosensors

Nature Chemical Biology, Journal Year: 2021, Volume and Issue: 17(5), P. 509 - 518

Published: Feb. 8, 2021

Language: Английский

---