In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing DOI Creative Commons
Xiaocheng Wang, Chaoyu Yang, Yunru Yu

et al.

Research, Journal Year: 2022, Volume and Issue: 2022

Published: Jan. 1, 2022

Three-dimensional (3D) bioprinting has been extensively explored for tissue repair and regeneration, while the insufficient nutrient oxygen availability in printed constructs, as well lack of adaptive dimensions shapes, compromises overall therapeutic efficacy limits their further application. Herein, inspired by natural symbiotic relationship between salamanders algae, we present novel living photosynthetic scaffolds using an situ microfluidic-assisted 3D strategy adapting irregular-shaped wounds promoting healing. As oxygenic photosynthesis unicellular microalga (Chlorella pyrenoidosa) was incorporated during printing, generated could produce sustainable under light illumination, which facilitated cell proliferation, migration, differentiation even hypoxic conditions. Thus, when microalgae-laden were directly into diabetic wounds, they significantly accelerate chronic wound closure alleviating local hypoxia, increasing angiogenesis, extracellular matrix (ECM) synthesis. These results indicate that microalgae offers effective autotrophic biosystem healing, suggesting a promising diverse engineering applications.

Language: Английский

Chronic wounds DOI
Vincent Falanga, R. Rivkah Isseroff, Athena M. Soulika

et al.

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 8(1)

Published: July 21, 2022

Language: Английский

Citations

460
Interferon target-gene expression and epigenomic signatures in health and disease DOI
Franck J. Barrat, Mary K. Crow, Lionel B. Ivashkiv

et al.

Nature Immunology, Journal Year: 2019, Volume and Issue: 20(12), P. 1574 - 1583

Published: Nov. 19, 2019

Language: Английский

Citations

421
Helper T cell differentiation DOI Open Access
Jordy Saravia, Nicole M. Chapman, Hongbo Chi

et al.

Cellular and Molecular Immunology, Journal Year: 2019, Volume and Issue: 16(7), P. 634 - 643

Published: March 12, 2019

Citations

392
Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions DOI Creative Commons
Britta De Pessemier, Lynda Grine,

Melanie Debaere

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(2), P. 353 - 353

Published: Feb. 11, 2021

The microbiome plays an important role in a wide variety of skin disorders. Not only is the altered, but also surprisingly many diseases are accompanied by altered gut microbiome. key regulator for immune system, as it aims to maintain homeostasis communicating with tissues and organs bidirectional manner. Hence, dysbiosis and/or associated response, promoting development diseases, such atopic dermatitis, psoriasis, acne vulgaris, dandruff, even cancer. Here, we focus on associations between microbiome, diet, metabolites, responses pathologies. This review describes exhaustive list common conditions well current body evidence dysbiosis, dietary links, their interplay conditions. An enhanced understanding local including underlying mechanisms necessary shed light microbial involvement human develop new therapeutic approaches.

Language: Английский

Citations

385
Host–microbiota interactions in immune-mediated diseases DOI
William Ruff, Teri M. Greiling, Martin Kriegel

et al.

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 18(9), P. 521 - 538

Published: May 26, 2020

Language: Английский

Citations

370
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications DOI Creative Commons
Warren J. Leonard,

Jian‐Xin Lin,

John J. O’Shea

et al.

Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 832 - 850

Published: April 1, 2019

Language: Английский

Citations

303
Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease DOI Open Access
Kalil Alves de Lima, Justin Rustenhoven, Jonathan Kipnis

et al.

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 597 - 620

Published: April 26, 2020

Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous exciting findings on microglia, the resident macrophages of central nervous system (CNS). This review addresses meningeal immunity, less-studied aspect neuroimmune interactions. The meninges, triple layer membranes—the pia mater, arachnoid and dura mater—surround CNS, encompassing cerebrospinal fluid produced by choroid plexus epithelium. Unlike adjacent brain parenchyma, meninges contain wide repertoire immune cells. These constitute which is primarily concerned with surveillance and—according to recent evidence—also participates in postinjury CNS recovery, chronic neurodegenerative conditions, even higher function. Meningeal immunity come under spotlight owing characterization lymphatic vessels draining CNS. Here, we current state our understanding its effects healthy diseased brains.

Language: Английский

Citations

264
Microbial exposure during early human development primes fetal immune cells DOI Creative Commons
Archita Mishra, Ghee Chuan Lai, Jing Yao Leong

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(13), P. 3394 - 3409.e20

Published: June 1, 2021

The human fetal immune system begins to develop early during gestation; however, factors responsible for immune-priming remain elusive. We explored potential exposure microbial agents in utero and their contribution toward activation of memory T cells tissues. profiled microbes across organs using 16S rRNA gene sequencing detected low but consistent signal gut, skin, placenta, lungs the 2nd trimester gestation. identified several live bacterial strains including Staphylococcus Lactobacillus tissues, which induced vitro mesenteric lymph node, supporting role immune-priming. Finally, SEM RNA-ISH, we visualized discrete localization bacteria-like structures eubacterial-RNA within 14th weeks gut lumen. These findings indicate selective presence gestation have broader implications establishment competency priming before birth.

Language: Английский

Citations

228
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions DOI Creative Commons

Tianqi Leng,

Hossain Delowar Akther,

Carl-Philipp Hackstein

et al.

Cell Reports, Journal Year: 2019, Volume and Issue: 28(12), P. 3077 - 3091.e5

Published: Sept. 1, 2019

Language: Английский

Citations

216
Control of Immunity by the Microbiota DOI
Eduard Ansaldo, Taylor K. Farley, Yasmine Belkaid

et al.

Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 449 - 479

Published: April 26, 2021

The immune system has coevolved with extensive microbial communities living on barrier sites that are collectively known as the microbiota. It is increasingly clear antigens and metabolites engage in a constant dialogue system, leading to microbiota-specific responses occur absence of inflammation. This form homeostatic immunity encompasses many arms immunity, including B cell responses, innate-like T cells, conventional helper regulatory responses. In this review we summarize examples adaptive microbiota, focusing fundamental aspects commensal recognition across different sites. Furthermore, explore how cross talk established during development, emphasizing critical temporal windows establish long-term function. Finally, highlight dysregulation microbiota can lead inflammation disease, pinpoint outstanding questions controversies regarding system–microbiota interactions.

Language: Английский

Citations

212