Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Cell,
Journal Year:
2023,
Volume and Issue:
186(2), P. 287 - 304.e26
Published: Jan. 1, 2023
Whether
and
how
certain
transposable
elements
with
viral
origins,
such
as
endogenous
retroviruses
(ERVs)
dormant
in
our
genomes,
can
become
awakened
contribute
to
the
aging
process
is
largely
unknown.
In
human
senescent
cells,
we
found
that
HERVK
(HML-2),
most
recently
integrated
ERVs,
are
unlocked
transcribe
genes
produce
retrovirus-like
particles
(RVLPs).
These
RVLPs
constitute
a
transmissible
message
elicit
senescence
phenotypes
young
which
be
blocked
by
neutralizing
antibodies.
The
activation
of
ERVs
was
also
observed
organs
aged
primates
mice
well
tissues
serum
from
elderly.
Their
repression
alleviates
cellular
tissue
degeneration
and,
some
extent,
organismal
aging.
findings
indicate
resurrection
hallmark
driving
force
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
15(1), P. 1 - 30
Published: Dec. 14, 2023
Aging
is
a
dynamic,
time-dependent
process
that
characterized
by
gradual
accumulation
of
cell
damage.
Continual
functional
decline
in
the
intrinsic
ability
living
organisms
to
accurately
regulate
homeostasis
leads
increased
susceptibility
and
vulnerability
diseases.
Many
efforts
have
been
put
forth
understand
prevent
effects
aging.
Thus,
major
cellular
molecular
hallmarks
aging
identified,
their
relationships
age-related
diseases
malfunctions
explored.
Here,
we
use
data
from
CAS
Content
Collection
analyze
publication
landscape
recent
aging-related
research.
We
review
advances
knowledge
delineate
trends
research
advancements
on
factors
attributes
across
time
geography.
also
current
concepts
related
molecular,
cellular,
organismic
level,
age-associated
diseases,
with
attention
brain
health,
as
well
biochemical
processes
associated
Major
outlined,
correlations
features
are
hope
this
will
be
helpful
for
apprehending
field
mechanisms
progression,
an
effort
further
solve
remaining
challenges
fulfill
its
potential.
Ageing Research Reviews,
Journal Year:
2023,
Volume and Issue:
88, P. 101956 - 101956
Published: May 20, 2023
Epigenetic
aging
clocks
have
gained
significant
attention
as
a
tool
for
predicting
age-related
health
conditions
in
clinical
and
research
settings.
They
enabled
geroscientists
to
study
the
underlying
mechanisms
of
assess
effectiveness
anti-aging
therapies,
including
diet,
exercise
environmental
exposures.
This
review
explores
effects
modifiable
lifestyle
factors'
on
global
DNA
methylation
landscape,
seen
by
clocks.
We
also
discuss
through
which
these
factors
contribute
biological
provide
comments
what
findings
mean
people
willing
build
an
evidence-based
pro-longevity
lifestyle.
The Innovation,
Journal Year:
2023,
Volume and Issue:
4(1), P. 100380 - 100380
Published: Jan. 1, 2023
•An
atlas
of
age-,
tissue-,
and
cell-type-specific
benefits
long-term
exercise.•Exercise
protects
tissues
from
infectious
injury,
especially
in
younger
ones.•Exercise
promotes
rejuvenation
aged
tissues,
the
nervous
system.•Exercise
exerts
geroprotective
effects,
by
resetting
circadian
programs
via
clock
protein
BMAL1.
Exercise
whole
organism,
yet,
how
across
body
orchestrally
respond
to
exercise
remains
enigmatic.
Here,
young
old
mice,
with
or
without
exercise,
exposed
we
characterized
phenotypic
molecular
adaptations
a
12-month
14
tissues/organs
at
single-cell
resolution.
Overall,
although
more
effectively
animals,
individuals
terms
inflammaging
suppression
tissue
rejuvenation,
structural
improvement
central
system
systemic
vasculature
being
most
prominent.
In
vascular
endothelial
cells,
found
that
readjusting
rhythmic
machinery
core
BMAL1
delayed
senescence
facilitated
recovery
damage,
recapitulating
beneficial
effects
exercise.
Our
study
underscores
effect
reconstituting
youthful
network
provides
foundation
for
further
investigating
interplay
between
aging,
immune
challenges
organism.
European Heart Journal,
Journal Year:
2024,
Volume and Issue:
45(39), P. 4219 - 4235
Published: Aug. 1, 2024
Vascular
smooth
muscle
cell
(VSMC)
senescence
is
crucial
for
the
development
of
atherosclerosis,
characterized
by
metabolic
abnormalities.
Tumour
necrosis
factor
receptor-associated
protein
1
(TRAP1),
a
regulator
associated
with
ageing,
might
be
implicated
in
atherosclerosis.
As
role
TRAP1
atherosclerosis
remains
elusive,
this
study
aimed
to
examine
function
VSMC
and
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
95, P. 102204 - 102204
Published: Jan. 23, 2024
The
pursuit
for
the
fountain
of
youth
has
long
been
a
fascination
amongst
scientists
and
humanity.
Ageing
is
broadly
characterized
by
cellular
decline
with
increased
susceptibility
to
age-related
diseases,
being
intimately
associated
epigenetic
modifications.
Recently,
reprogramming-induced
rejuvenation
strategies
have
begun
greatly
alter
longevity
research
not
only
tackle
defects
but
also
possibly
reverse
ageing
process.
Hence,
in
this
review,
we
highlight
major
changes
during
state-of-art
current
emerging
reprogramming
leveraging
on
transcription
factors.
Notably,
partial
enables
resetting
clock
without
erasing
identity.
Promising
chemical-based
harnessing
small
molecules,
including
DNA
methyltransferase
histone
deacetylase
inhibitors
are
discussed.
Moreover,
parallel
interventions,
foundations
clocks
accurate
assessment
evaluation
approaches
briefly
presented.
Going
further,
such
scientific
breakthroughs,
witnessing
rise
biotech
industry
aiming
extend
health
span
ideally
achieve
human
one
day.
In
context,
overview
main
scenarios
proposed
future
socio-economic
ethical
challenges
an
field.
Ultimately,
review
aims
inspire
interventions
that
promote
healthy
all.
