Lipopolysaccharide and the gut microbiota: considering structural variation DOI Open Access
Alex E. Mohr, Meli’sa Crawford, Paniz Jasbi

et al.

FEBS Letters, Journal Year: 2022, Volume and Issue: 596(7), P. 849 - 875

Published: March 9, 2022

Systemic inflammation is associated with chronic disease and purported to be a main pathogenic mechanism underlying metabolic conditions. Microbes harbored in the host gastrointestinal tract release signaling byproducts from their cell wall, such as lipopolysaccharides (LPS), which can act locally and, after crossing gut barrier entering circulation, also systemically. Defined endotoxemia, elevated concentrations of LPS circulation are conditions disease. As such, measurement highly prevalent animal human research investigating these states. Indeed, potent stimulant immunity, but this response depends on microbial species’ origin, parameter often overlooked both preclinical clinical investigations. lipid A portion mutable comprises virulence endotoxic component, thus contributing structural functional diversity among LPSs species. In review, we discuss how differences induce differential immunological responses host.

Language: Английский

Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients DOI Creative Commons
Youenn Jouan, Antoine Guillon, Loïc Gonzalez

et al.

The Journal of Experimental Medicine, Journal Year: 2020, Volume and Issue: 217(12)

Published: Sept. 4, 2020

COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the is a key feature ARDS pathophysiology. However, cellular actors involved COVID-19–driven are poorly understood. Here, blood and airways of severe patients, we serially analyzed unconventional T cells, heterogeneous class lymphocytes (MAIT, γδT, iNKT cells) with potent antimicrobial regulatory functions. Circulating cells patients presented profound persistent phenotypic alteration. In airways, highly activated were detected, suggesting potential contribution regulation local inflammation. Finally, expression CD69 activation marker on MAIT admission was predictive clinical course disease severity. Thus, present an altered cell biology, further investigations will be required precisely assess their functions during SARS–CoV-2–driven ARDS.

Language: Английский

Citations

173
Staphylococcus epidermidis and its dual lifestyle in skin health and infection DOI

Morgan M. Severn,

Alexander R. Horswill

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 21(2), P. 97 - 111

Published: Aug. 30, 2022

Language: Английский

Citations

165
The wound microbiota: microbial mechanisms of impaired wound healing and infection DOI

Aayushi Uberoi,

Amelia R. McCready-Vangi,

Elizabeth A. Grice

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(8), P. 507 - 521

Published: April 4, 2024

Language: Английский

Citations

162
Bile acids drive the newborn’s gut microbiota maturation DOI Creative Commons
Niels van Best, Ulrike Rolle‐Kampczyk, Frank G. Schaap

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: July 23, 2020

Abstract Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense highly dynamic intestinal microbiota. Whereas effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, liver undergoes functional transition from hematopoietic organ central metabolic regulation immune surveillance. The aim present study was analyze influence developing hepatic function metabolism on early Here, we report characterization colonization dynamics in murine gastrointestinal tract ( n = 6–10 per age group) using metabolomic profiling combination multivariate analysis. We observed major age-dependent changes identified bile acids as potent drivers microbiota maturation. Consistently, oral administration tauro-cholic acid or β-tauro-murocholic newborn mice 7–14 accelerated postnatal

Language: Английский

Citations

154
An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint DOI Creative Commons
Deepshika Ramanan, Esen Sefik, Silvia Galván-Peña

et al.

Cell, Journal Year: 2020, Volume and Issue: 181(6), P. 1276 - 1290.e13

Published: May 12, 2020

Language: Английский

Citations

150
MAIT Cell Development and Functions: the Microbial Connection DOI Creative Commons
François Legoux, Marion Salou, Olivier Lantz

et al.

Immunity, Journal Year: 2020, Volume and Issue: 53(4), P. 710 - 723

Published: Oct. 1, 2020

Language: Английский

Citations

148
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease DOI
Katherine Donald, B. Brett Finlay

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(11), P. 735 - 748

Published: May 3, 2023

Language: Английский

Citations

145
Interleukin-17 governs hypoxic adaptation of injured epithelium DOI
Piotr Konieczny, Yue Xing, Ikjot Sidhu

et al.

Science, Journal Year: 2022, Volume and Issue: 377(6602)

Published: June 16, 2022

Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is insufficient trigger HIF1α damaged epithelium. Instead, multimodal single-cell and spatial transcriptomics analyses functional studies reveal retinoic acid-related orphan receptor γt

Language: Английский

Citations

143
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota DOI Creative Commons
Djalma S. Lima-Júnior, Siddharth R. Krishnamurthy, Nicolas Bouladoux

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(14), P. 3794 - 3811.e19

Published: June 23, 2021

The microbiota plays a fundamental role in regulating host immunity. However, the processes involved initiation and regulation of immunity to remain largely unknown. Here, we show that skin promotes discrete expression defined endogenous retroviruses (ERVs). Keratinocyte-intrinsic responses ERVs depended on cyclic GMP-AMP synthase (cGAS)/stimulator interferon genes protein (STING) signaling promoted induction commensal-specific T cells. Inhibition ERV reverse transcription significantly impacted these responses, resulting impaired its associated tissue repair function. Conversely, lipid-enriched diet primed for heightened ERV- response commensal colonization, leading increased immune inflammation. Together, our results support idea may have co-opted virome as means communicate with exogenous microbiota, multi-kingdom dialog controls both homeostasis

Language: Английский

Citations

142
Living in Your Skin: Microbes, Molecules, and Mechanisms DOI Creative Commons
Mary Hannah Swaney, Lindsay Kalan

Infection and Immunity, Journal Year: 2021, Volume and Issue: 89(4)

Published: March 16, 2021

Human skin functions as a physical, chemical, and immune barrier against the external environment while also providing protective niche for its resident microbiota, known microbiome. Cooperation between host cells, system is responsible maintenance of health, disruption to this delicate balance, such by pathogen invasion or breach in barrier, may lead impaired function.

Language: Английский

Citations

136