The plant immune system: From discovery to deployment DOI Creative Commons
Jonathan D. G. Jones, Brian J. Staskawicz, Jeffery L. Dangl

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(9), P. 2095 - 2116

Published: April 1, 2024

Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. breeders discovered Mendelian genetic loci conferring disease resistance specific isolates over 100 years ago. Subsequent breeding for underpins modern agriculture and, along with the emergence focus on model plants genetics genomics research, has provided rich resources molecular biological exploration last 50 years. These studies led identification of extracellular intracellular receptors that convert recognition microbe-encoded patterns or pathogen-delivered virulence effectors into defense activation. receptor systems, downstream responses, define plant immune systems have evolved since migration land ∼500 million Our current understanding provides platform development rational enhancement control many continue plague crop production.

Language: Английский

Mutual potentiation of plant immunity by cell-surface and intracellular receptors DOI
Bruno Pok Man Ngou, Heekyung Ahn, Pingtao Ding

et al.

Nature, Journal Year: 2021, Volume and Issue: 592(7852), P. 110 - 115

Published: March 10, 2021

Language: Английский

Citations

753
PTI-ETI crosstalk: an integrative view of plant immunity DOI
Minhang Yuan, Bruno Pok Man Ngou, Pingtao Ding

et al.

Current Opinion in Plant Biology, Journal Year: 2021, Volume and Issue: 62, P. 102030 - 102030

Published: March 7, 2021

Language: Английский

Citations

607
Thirty years of resistance: Zig-zag through the plant immune system DOI Creative Commons
Bruno Pok Man Ngou, Pingtao Ding, Jonathan D. G. Jones

et al.

The Plant Cell, Journal Year: 2022, Volume and Issue: 34(5), P. 1447 - 1478

Published: Feb. 10, 2022

Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate detection-and-response system. The first Resistance (R) gene was cloned in 1992 . Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat (NLRs) cloned. Here, we provide list of characterized PRRs NLRs. In addition receptors, components signaling networks were discovered over last 30 years. We review pathways, physiological responses, molecular regulation both PRR- NLR-mediated immunity. Recent studies reinforced importance interactions between two systems. an overview immunity, highlighting challenges perspectives future research.

Language: Английский

Citations

569
The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling DOI Creative Commons
Guozhi Bi, Min Su, Nan Li

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(13), P. 3528 - 3541.e12

Published: May 12, 2021

Language: Английский

Citations

434
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ DOI
Raoul Martin, Tiancong Qi, Haibo Zhang

et al.

Science, Journal Year: 2020, Volume and Issue: 370(6521)

Published: Dec. 4, 2020

Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) detect pathogen effectors and trigger a plant's response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (TIR) domains (TIR-NLRs) (see Perspective by Tian Li). Ma et al. studied Arabidopsis thaliana TIR-NLR RPP1 (recognition Peronospora parasitica 1) its response to from an oomycete pathogen. Martin Nicotiana benthamiana ROQ1 XopQ Xanthomonas effector. Both found these TIR-NLRs formed tetramers that, when activated binding effector, exposed active site nicotinamide adenine dinucleoside (NAD) hydrolase. Thus, recognition effector initiates NAD hydrolysis begins Science , this issue p. eabe3069 eabd9993 ; see also 1163

Language: Английский

Citations

391
Evasion of plant immunity by microbial pathogens DOI
Yan Wang, Rory N. Pruitt, Thorsten Nürnberger

et al.

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(8), P. 449 - 464

Published: March 16, 2022

Language: Английский

Citations

269
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration DOI Creative Commons
Matthew D. Figley, Weixi Gu, Jeffrey D. Nanson

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(7), P. 1118 - 1136.e11

Published: March 2, 2021

Language: Английский

Citations

258
Plant immune networks DOI
Bruno Pok Man Ngou, Jonathan D. G. Jones, Pingtao Ding

et al.

Trends in Plant Science, Journal Year: 2021, Volume and Issue: 27(3), P. 255 - 273

Published: Sept. 18, 2021

Language: Английский

Citations

228
A wheat resistosome defines common principles of immune receptor channels DOI Creative Commons
Alexander Förderer, Ertong Li, Aaron W. Lawson

et al.

Nature, Journal Year: 2022, Volume and Issue: 610(7932), P. 532 - 539

Published: Sept. 26, 2022

Abstract Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses 1 . Indirect recognition of a effector by the dicotyledonous Arabidopsis thaliana coiled-coil domain containing NLR (CNL) ZAR1 induces formation large hetero-oligomeric protein complex, termed resistosome, which functions as calcium channel required for ZAR1-mediated immunity 2–4 Whether resistosome and activities are conserved among plant CNLs remains unknown. Here we report cryo-electron microscopy structure wheat CNL Sr35 5 in complex with AvrSr35 6 stem rust pathogen. Direct binding repeats results pentameric Sr35–AvrSr35 term resistosome. Wheat resistosomes bear striking structural similarities, including an arginine cluster not previously recognized conserved, co-occurs forms intramolecular interactions 'EDVID' motif domain. Electrophysiological measurements show that exhibits non-selective cation activity. These insights allowed us generate new variants closely related barley orphan NLRs recognize AvrSr35. Our data support evolutionary conservation plants demonstrate proof principle structure-based engineering crop improvement.

Language: Английский

Citations

193
Prokaryotic innate immunity through pattern recognition of conserved viral proteins DOI
Linyi Gao, Max E. Wilkinson, Jonathan Strecker

et al.

Science, Journal Year: 2022, Volume and Issue: 377(6607)

Published: Aug. 11, 2022

Many organisms have evolved specialized immune pattern-recognition receptors, including nucleotide-binding oligomerization domain-like receptors (NLRs) of the STAND superfamily that are ubiquitous in plants, animals, and fungi. Although roles NLRs eukaryotic immunity well established, it is unknown whether prokaryotes use similar defense mechanisms. Here, we show antiviral (Avs) homologs bacteria archaea detect hallmark viral proteins, triggering Avs tetramerization activation diverse N-terminal effector domains, DNA endonucleases, to abrogate infection. Cryo-electron microscopy reveals sensor domains recognize conserved folds, active-site residues, enzyme ligands, allowing a single receptor wide variety viruses. These findings extend paradigm pattern recognition pathogen-specific proteins across all three life.

Language: Английский

Citations

176