Inflammation and aging: signaling pathways and intervention therapies

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 8, 2023

Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical

Language: Английский

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Sex Differences in Immunity

Annual Review of Immunology, Journal Year: 2022, Volume and Issue: 40(1), P. 75 - 94

Published: Jan. 5, 2022

Strong epidemiological evidence now exists that sex is an important biologic variable in immunity. Recent studies, for example, have revealed differences are associated with the severity of symptoms and mortality due to coronavirus disease 2019 (COVID-19). Despite this evidence, much remains be learned about mechanisms underlying associations between immune-mediated conditions. A growing body experimental data has made significant inroads into understanding sex-influenced immune responses. As physicians seek provide more targeted patient care, it critical understand how sex-defining factors (e.g., chromosomes, gonadal hormones) alter responses health disease. In review, we highlight recent insights autoimmunity; virus infection, specifically severe acute respiratory syndrome 2 (SARS-CoV-2) infection; cancer immunotherapy. deeper will allow development a sex-based approach screening treatment.

Language: Английский

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Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)

Cardiovascular Research, Journal Year: 2021, Volume and Issue: 117(14), P. 2705 - 2729

Published: Sept. 11, 2021

The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory immune responses are characteristic features of severe COVID-19. Pre-existing disease load linked myocardial injury worse outcomes. vascular response cytokine production interaction between acute respiratory syndrome coronavirus-2 (SARS-CoV-2) angiotensin-converting enzyme 2 receptor may lead a significant reduction cardiac contractility subsequent dysfunction. In addition, considerable proportion patients who have been infected with SARS-CoV-2 do not fully recover continue experience large number symptoms post-acute complications absence detectable infection. This conditions often referred as 'post-acute COVID-19' multiple causes. Viral reservoirs lingering fragments RNA proteins contribute condition. Systemic COVID-19 has potential increase fibrosis which turn impair remodelling. Here, we summarize current knowledge sequelae As pandemic continues new variants emerge, can advance our underlying mechanisms only by integrating understanding pathophysiology corresponding clinical findings. Identification biomarkers complications, development effective treatments for crucial importance.

Language: Английский

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Lack of consideration of sex and gender in COVID-19 clinical studies

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: July 6, 2021

Abstract Sex and gender differences impact the incidence of SARS-CoV-2 infection COVID-19 mortality. Furthermore, sex influence frequency severity pharmacological side effects. A large number clinical trials to develop new therapeutic approaches vaccines for are ongoing. We investigated inclusion and/or in studies on ClinicalTrials.gov, collecting data period January 1, 2020 26, 2021. Here, we show that 4,420 registered SARS-CoV-2/COVID-19 studies, 935 (21.2%) address sex/gender solely context recruitment, 237 (5.4%) plan sex-matched or representative samples emphasized reporting, only 178 (4%) explicitly report a include as an analytical variable. Just eight (17.8%) 45 related published scientific journals until December 15, sex-disaggregated results subgroup analyses.

Language: Английский

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Sexual dimorphism in COVID-19: potential clinical and public health implications

The Lancet Diabetes & Endocrinology, Journal Year: 2022, Volume and Issue: 10(3), P. 221 - 230

Published: Feb. 1, 2022

Language: Английский

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COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 27, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated symptoms, named disease 2019 (COVID-19), have rapidly spread worldwide, resulting in the declaration of a pandemic. When several countries began enacting quarantine lockdown policies, pandemic as it is now known truly began. While most patients minimal approximately 20% verified subjects are suffering from serious medical consequences. Co-existing diseases, such cardiovascular disease, cancer, diabetes, others, been shown to make more vulnerable severe outcomes COVID-19 by modulating host–viral interactions immune responses, causing infection mortality. In this review, we outline putative signaling pathways at interface emphasizing clinical molecular implications concurring diseases outcomes. As evidence limited on co-existing COVID-19, findings preliminary, further research required for optimal management with comorbidities.

Language: Английский

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Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies

Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(5), P. 288 - 306

Published: March 13, 2023

Language: Английский

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The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(5), P. 780 - 791

Published: March 16, 2023

Language: Английский

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Gender Differences in COVID-19 Related Attitudes and Behavior: Evidence from a Panel Survey in Eight OECD Countries

Published: June 1, 2020

Using original data from two waves of a survey conducted in March and April 2020 eight OECD countries (N = 21,649), we show that women are more likely to see COVID-19 as very serious health problem, agree with restraining public policy measures adopted response it, comply them.Gender differences attitudes behavior substantial all countries, robust controlling for large set sociodemographic, employment, psychological, behavioral factors, only partially mitigated individuals who cohabit or have direct exposure COVID-19.The results not driven by differential social desirability bias.They carry important implications the spread pandemic may contribute explain gender vulnerability it.

Language: Английский

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Sex and gender differences in COVID-19: More to be learned!

American Heart Journal Plus Cardiology Research and Practice, Journal Year: 2021, Volume and Issue: 3, P. 100011 - 100011

Published: March 1, 2021

The COVID-19 pandemic has affected millions of patients across the globe. Multiple studies, national and international governmental data have shown important sex gender differences in incidence outcomes with COVID-19. These are not only attributed to age comorbid conditions but likely a combination factors, including hormonal differences, immune response, inflammatory markers behavioral attitudes, among others. In this review, we discuss studies addressing sex- gender-specific infections focus on potential pathophysiological mechanisms these differences.

Language: Английский

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