Nervous system in colorectal cancer DOI
Chunjie Xu, Chunhui Jiang, Yuan Tian

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217431 - 217431

Published: Dec. 1, 2024

Language: Английский

Hyperexcitation of ovBNST CRF neurons during stress contributes to female-biased expression of anxiety-like avoidance behaviors DOI Creative Commons
N. Zhang, Sha Zhao, Yanqiao Ma

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(19)

Published: May 10, 2024

Corticotropin releasing factor (CRF) network in the oval nucleus of bed nuclei stria terminalis (ovBNST) is generally indicated stress, but its role female-biased susceptibility to anxiety unknown. Here, we established a stress paradigm. We found that CRF release ovBNST during showed pattern, and neurons were more prone be hyperexcited female mice both vitro vivo studies. Moreover, optogenetic modulation exchange activation pattern between male could reverse their anxiety. Last, receptor type 1 (CRFR1) mediated CRF-induced excitation expression. Specific knockdown CRFR1 level or overexpression Therefore, identify CRFR1-mediated hyperexcitation encode

Language: Английский

Citations

9
Comparative perspectives on neuropeptide function and social isolation DOI
Kenta Asahina, Moriel Zelikowsky

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function DOI Creative Commons
Ceren Incedal Nilsson, Özge Dumral, Gonzalo M. Sánchez

et al.

The EMBO Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Somatostatin, released from δ-cells within pancreatic islets of Langerhans, is one the most important negative regulators islet hormone secretion. We find that are positioned near, and release somatostatin onto, primary cilia other cell types, including insulin-secreting β-cells. Somatostatin activates ciliary receptors, resulting in rapid lowering cAMP concentration which turn promotes more sustained nuclear translocation cilia-dependent transcription factor GLI2 through a mechanism operates parallel with canonical Hedgehog pathway depends on Ca 2+ signaling. also length reduced human donors type-2 diabetes, associated reduction interactions between cilia. Our findings show constitute an target action, endows ability to regulate function beyond acute suppression release.

Language: Английский

Citations

1
Using synthetic biology to understand the gut-brain axis DOI Creative Commons
Angela Cesaro, Esther Broset, Gregory J. Salimando

et al.

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102458 - 102458

Published: Feb. 1, 2025

Language: Английский

Citations

1
Adolescent binge drinking leads to long-lasting changes in cortical microcircuits in mice DOI Creative Commons
Avery R. Sicher,

William D. Starnes,

Keith R. Griffith

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 234, P. 109561 - 109561

Published: May 1, 2023

Adolescent drug consumption has increased risks to the individual compared in adulthood, due likelihood of long-term and permanent behavioral neurological adaptations. However, little is known about how adolescent alcohol influences maturation trajectory cortical circuit development. Here, we explore consequences binge drinking on somatostatin (SST) neuronal function superficial layers prelimbic (PL) cortex male female SST-Ai9 mice. We find that drinking-in-the-dark (DID) produces sex-dependent increases intrinsic excitability SST neurons, with no change overall cell number, persisting well into adulthood. While did not evidence altered GABA release from neurons onto other within circuit, found a complementary reduction layer II/III pyramidal neuron immediately after drinking; however, this hypoexcitability rebounded towards activity adulthood females, suggesting homeostatic adaptations circuit. Together, suggests during key developmental timepoints leads changes PL microcircuitry function, which may have broad implications.

Language: Английский

Citations

21
Distinct circuits and molecular targets of the paraventricular hypothalamus decode visceral and somatic pain DOI Creative Commons
Yongchang Li,

Fu‐Chao Zhang,

Di Li

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

8
Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals DOI Creative Commons
Anneliese M. M. Gest, Ayse Z. Sahan, Yanghao Zhong

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(22), P. 12573 - 12660

Published: Nov. 13, 2024

Cellular function is controlled through intricate networks of signals, which lead to the myriad pathways governing cell fate. Fluorescent biosensors have enabled study these signaling in living systems across temporal and spatial scales. Over years there has been an explosion number fluorescent biosensors, as they become available for numerous targets, utilized spectral space, suited various imaging techniques. To guide users this extensive biosensor landscape, we discuss critical aspects proteins consideration development, smart tagging strategies, historical recent types, grouped by target, with a focus on design applications sensors systems.

Language: Английский

Citations

8
Heterosynaptic plasticity of the visuo-auditory projection requires cholecystokinin released from entorhinal cortex afferents DOI Creative Commons
Wenjian Sun, Haohao Wu, Yujie Peng

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: March 4, 2024

The entorhinal cortex is involved in establishing enduring visuo-auditory associative memory the neocortex. Here we explored mechanisms underlying this synaptic plasticity related to projections from visual and cortices auditory mice using optogenetics of dual pathways. High-frequency laser stimulation (HFS laser) projection did not induce long-term potentiation. However, after pairing with sound stimulus, inputs were potentiated following either infusion cholecystokinin (CCK) or HFS entorhino-auditory CCK-expressing projection. Combining retrograde tracing RNAscope situ hybridization, show that Cck expression higher neurons projecting than those originating cortex. In presence CCK, potentiation neocortex occurred when presynaptic input arrived 200 ms before postsynaptic firing, even just five trials pairing. Behaviorally, inactivation CCK+ blocked formation memory. Our results indicate neocortical association formed through heterosynaptic plasticity, which depends on release CCK mostly afferents.

Language: Английский

Citations

7
Microscale droplet assembly enables biocompatible multifunctional modular iontronics DOI
Yujia Zhang, Cheryl Tan, Christopher N. Toepfer

et al.

Science, Journal Year: 2024, Volume and Issue: 386(6725), P. 1024 - 1030

Published: Nov. 28, 2024

Hydrogel iontronic devices can emulate biological functions and communicate with living matter. But the fabrication of miniature, soft according to modular designs has not been achieved. In this work, we report use surfactant-supported assembly freestanding microscale hydrogel droplets construct various modules, circuits, biointerfaces. Chemical modifications silk fibroin produced a pair oppositely charged hydrogels. Microscale combinations diodes, npn- pnp-type transistors, diverse reconfigurable logic gates. Through incorporation poly(amino acid)s, have demonstrated droplet-based synthetic synapse ionic polymer-mediated long-term plasticity. Further, our transistor serve as biocompatible sensor record electrophysiological signals from sheets human cardiomyocytes, paving way building miniature bioiontronic systems.

Language: Английский

Citations

7
Synthetic GPCRs for programmable sensing and control of cell behaviour DOI Creative Commons
Nicholas A. Kalogriopoulos, Reika Tei,

Yuqi Yan

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

Citations

7