Tumor Microenvironment Modulation by Cancer-Derived Extracellular Vesicles DOI Creative Commons
Artem Ten, Vadim Kumeiko, Vladislav M. Farniev

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 682 - 682

Published: April 15, 2024

The tumor microenvironment (TME) plays an important role in the process of tumorigenesis, regulating growth, metabolism, proliferation, and invasion cancer cells, as well contributing to resistance conventional chemoradiotherapies. Several types cells with relatively stable phenotypes have been identified within TME, including cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), neutrophils, natural killer (NK) which shown modulate cell metastasis, interaction immune system, thus promoting heterogeneity. Growing evidence suggests that tumor-cell-derived extracellular vesicles (EVs), via transfer various molecules (e.g., RNA, proteins, peptides, lipids), play a pivotal transformation normal TME into their protumorigenic counterparts. This review article focuses on functions EVs modulation view how exosomes contribute importance for diagnosis therapy.

Language: Английский

Metastasis DOI Creative Commons

Stefanie Gerstberger,

Qingwen Jiang, Karuna Ganesh

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

Citations

369
Immune determinants of the pre-metastatic niche DOI Creative Commons
Laura Pătraș, Lee Shaashua, Irina Matei

et al.

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 546 - 572

Published: March 1, 2023

Language: Английский

Citations

90
Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth DOI Creative Commons
Jialu Xu, Qingle Ma, Yue Zhang

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 10, 2022

Abstract Microbe-based cancer immunotherapy has recently emerged as a hot topic for treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction anticancer immunity our formulations appears to inversely correlate with their size due the ability accumulate tumor-draining lymph node (TDLN). Moreover, use percolation model explain distribution behavior toward TDLN. abundance functional orientation each effector component are significantly improved not only microenvironment tumor but also TDLN following small YCW NPs In combination programmed death-ligand 1 (PD-L1) blockade, demonstrate efficiency melanoma-challenged mice. We delineate potential strategy target immunosuppressive microbe-based nanoparticles highlight role effect immune therapeutics.

Language: Английский

Citations

87
The advent of immune stimulating CAFs in cancer DOI
Maria Tsoumakidou

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(4), P. 258 - 269

Published: Feb. 17, 2023

Language: Английский

Citations

80
Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions DOI Creative Commons

Haoran Ji,

Chuang Hu, Xuhui Yang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 27, 2023

Abstract Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, secondary dissemination to distant sites through a series of mechanisms, it has been proved that lymph node metastasis (LNM) is an essential prognostic indicator in many different types cancer. Therefore, oncologists understand the mechanisms tumor cells metastasize LNs, as well how LNM affects prognosis therapy patients with cancer order provide accurate disease assessment effective treatment strategies. In recent years, updates both basic clinical studies on application advanced medical technologies, much progress made understanding strategies diagnosis LNM. this review, current knowledge anatomical physiological characteristics molecular LNM, described. The significance summarized, including roles playing staging, prediction, selection various cancers. And novel exploration academic disputes recognition, diagnosis, therapeutic interventions LNs also discussed.

Language: Английский

Citations

74
Localization, tissue biology and T cell state — implications for cancer immunotherapy DOI
Jason M. Schenkel, Kristen E. Pauken

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(12), P. 807 - 823

Published: May 30, 2023

Language: Английский

Citations

66
Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy DOI Creative Commons

Yiming Xia,

Shunli Fu,

Qingping Ma

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: June 3, 2023

Abstract Immunotherapy has become a promising research “hotspot” in cancer treatment. “Soldier” immune cells are not uniform throughout the body; they accumulate mostly organs such as spleen and lymph nodes (LNs), etc. The unique structure of LNs provides microenvironment suitable for survival, activation, proliferation multiple types cells. play an important role both initiation adaptive immunity generation durable anti-tumor responses. Antigens taken up by antigen-presenting peripheral tissues need to migrate with lymphatic fluid activate lymphocytes therein. Meanwhile, accumulation retaining many functional compounds enhance their efficacy significantly. Therefore, have key target tumor immunotherapy. Unfortunately, nonspecific distribution drugs vivo greatly limits activation cells, which leads unsatisfactory effects. efficient nano-delivery system is effective strategy maximize drugs. Nano-delivery systems shown beneficial improving biodistribution enhancing lymphoid tissues, exhibiting powerful prospects achieving delivery LNs. Herein, physiological barriers were summarized factors affecting discussed thoroughly. Moreover, developments reviewed transformation targeting nanocarriers discussed.

Language: Английский

Citations

61
New insights into the correlations between circulating tumor cells and target organ metastasis DOI Creative Commons

Qinru Zhan,

Bixia Liu,

Xiaohua Situ

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 21, 2023

Organ-specific metastasis is the primary cause of cancer patient death. The distant tumor cells to specific organs depends on both intrinsic characteristics and extrinsic factors in their microenvironment. During an intermediate stage metastasis, circulating (CTCs) are released into bloodstream from metastatic tumors. CTCs harboring aggressive or features can extravasate remote sites for continuous colonizing growth, leading further lesions. In past decade, numerous studies demonstrated that exhibited huge clinical value including predicting assessing prognosis monitoring treatment response et al. Furthermore, increasingly experiments dedicated identifying key molecules inside exploring how they mediate CTC-related organ-specific metastasis. Based above molecules, more inhibitors being developed target utilized completely clean CTCs, which should provide promising prospects administer advanced tumor. Recently, application various nanomaterials microfluidic technologies enrichment technology has assisted improve our deep insights phenotypic biological functions as a potential therapy target, may pave way us make practical strategies. present review, we mainly focus role involved targeted organ especially latest molecular mechanism research intervention strategies related CTCs.

Language: Английский

Citations

59
Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity DOI

Siyuan You,

Shuqin Li,

Lingsu Zeng

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(8), P. 1415 - 1433.e12

Published: July 18, 2024

Language: Английский

Citations

23
Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor DOI Creative Commons
Ziyan Liao, Jie Jiang, Wei Wu

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(4)

Published: Jan. 11, 2024

ABSTRACT The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process T-cell proliferation lymph nodes. This scaffold gathers function loading, delivery, activation expansion CAR-T to enhance therapeutic effects on porous device made from poly(lactic-co-glycolic acid) microfluidic technique with modification stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well cytokines. fosters 50-fold cell vitro 15-fold vivo. Particularly, it maintains long-lasting up 30 days cervical tumor model significantly inhibits growth. biomimetic delivery strategy provides versatile platform treating

Language: Английский

Citations

20