Seminars in Immunology, Journal Year: 2017, Volume and Issue: 31, P. 20 - 29
Published: June 1, 2017
Language: Английский
Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 20(2), P. 69 - 84
Published: Nov. 20, 2018
Language: Английский
Citations
3125
Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 924 - 940
Published: April 1, 2019
Language: Английский
Citations
1805
Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)
Published: Oct. 11, 2021
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote growth, angiogenesis, invasion metastasis, along extracellular matrix (ECM) remodeling even chemoresistance. Numerous previous studies have confirmed critical role interaction between cells in tumorigenesis development. However, recently, mutual effects immune (TIME) been identified as another key factor promoting progression. The TIME mainly consists distinct populations islets is highly associated antitumor immunological state TME. interact tumor-infiltrating well other within via secretion various cytokines, growth factors, chemokines, exosomes effector molecules, consequently shaping an immunosuppressive TME that enables cancer to evade surveillance system. In-depth interactions, particularly complicated mechanisms connecting cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding direct indirect crosstalk infiltrating further summarize possible immunoinhibitory induced by In addition, present current related CAF-targeting immunotherapies briefly describe some future perspectives CAF research end.
Language: Английский
Citations
1458
Nature Immunology, Journal Year: 2016, Volume and Issue: 17(9), P. 1025 - 1036
Published: Aug. 19, 2016
Language: Английский
Citations
988
Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(3), P. 200 - 218
Published: Jan. 6, 2020
Language: Английский
Citations
981
Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 18(2), P. 85 - 100
Published: Sept. 15, 2020
Language: Английский
Citations
948
Nature, Journal Year: 2019, Volume and Issue: 574(7776), P. 45 - 56
Published: Oct. 2, 2019
Language: Английский
Citations
770
Gastroenterology, Journal Year: 2017, Volume and Issue: 153(3), P. 812 - 826
Published: June 16, 2017
Language: Английский
Citations
766
Cancer Cell, Journal Year: 2017, Volume and Issue: 32(2), P. 135 - 154
Published: Aug. 1, 2017
Language: Английский
Citations
654
Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)
Published: Aug. 6, 2020
Abstract The tumor microenvironment is highly complex, and immune escape currently considered an important hallmark of cancer, largely contributing to progression metastasis. Named for their capability killing target cells autonomously, natural killer (NK) serve as the main effector toward cancer in innate immunity are heterogeneous microenvironment. Most current treatment options harnessing focus on T cell-immunity, either by promoting activating signals or suppressing inhibitory ones. limited success achieved cell immunotherapy highlights importance developing new-generation immunotherapeutics, example utilizing previously ignored NK cells. Although tumors also evolve resist cell-induced cytotoxicity, cytokine supplement, blockade suppressive molecules genetic engineering may overcome such resistance with great promise both solid hematological malignancies. In this review, we summarized fundamental characteristics recent advances within immunometabolic microenvironment, discussed potential application limitations emerging cell-based therapeutic strategies era presicion medicine.
Language: Английский
Citations
644