A TrkB-mTOR Peptidomimetic Promotes Axon Regeneration and Restores Walking After Adult Spinal Cord Injury DOI

Chao‐wen Bai,

Chang She,

Huajian Shan

et al.

Published: Jan. 1, 2024

Language: Английский

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders DOI Creative Commons
Xin Yang, Yu‐Wen Alvin Huang, John Marshall

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(3), P. 715 - 724

Published: May 10, 2024

Tropomyosin receptor kinase B (TrkB) signaling plays a pivotal role in dendritic growth and spine formation to promote learning memory. The activity-dependent release of brain-derived neurotrophic factor at synapses binds pre- or postsynaptic TrkB resulting the strengthening synapses, reflected by long-term potentiation. Postsynaptically, association density protein-95 with enhances phospholipase Cγ-Ca2+/calmodulin-dependent protein II phosphatidylinositol 3-kinase-mechanistic target rapamycin required for In this review, we discuss TrkB-postsynaptic coupling as promising strategy magnify towards development novel therapeutics specific neurological disorders. A reduction has been observed neurodegenerative disorders, such Alzheimer's disease Huntington's disease, enhancement could mitigate deficiency neuronal connectivity schizophrenia depression. Treatment is problematic, due poor pharmacokinetics, low brain penetration, side effects from activation p75 neurotrophin truncated TrkB.T1 isoform. Although agonists antibodies that activate are being intensively investigated, they cannot distinguish multiple human splicing isoforms cell type-specific functions. Targeting provides an alternative approach specifically boost localized synaptic sites versus global stimulation risks many adverse effects.

Language: Английский

Citations

7
Ferroptosis: a novel mechanism of cell death in ophthalmic conditions DOI Creative Commons
Yaqi Yang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

Citations

5
Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats DOI
Xiaodi Chen,

Brynn Kroke,

Jun Ni

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115151 - 115151

Published: Jan. 19, 2025

Language: Английский

Citations

0
Exposure to malathion impairs learning and memory of zebrafish by disrupting cholinergic signal transmission, undermining synaptic plasticity, and aggravating neuronal apoptosis DOI
Yang Shu,

Weishang Zhou,

Weixia Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137391 - 137391

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Molecular Basis of Love DOI Open Access
Jaroslava Durdiaková, Gabriela Repiská

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1533 - 1533

Published: Feb. 12, 2025

Love as a complex interplay of emotions and behaviors is underpinned by an intricate network neurobiological mechanisms. This review provides insight into the molecular basis love, focusing on role key hormones neuromodulators. The aim paper to report how these biochemical messengers influence various aspects including attraction, attachment, long-term bonding. By examining effects such dopamine, oxytocin, vasopressin, serotonin, we elucidate relationship between biology behavior. Additionally, potential impact modern lifestyle factors hormonal balance their subsequent love social interactions are outlined. useful overview underpinnings offering insights biological mechanisms that shape human relationships.

Language: Английский

Citations

0
Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy DOI

Cong‐Yuan Xia,

Guo-Yan Zuo,

Manni Wang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Xanthouhumol relieves stress-induced depressive-like behaviors through the Sirt1/NF-κB/NLRP3 pathway DOI

Gangqiang Lin,

Yi Zhang, Jing Qin

et al.

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Language: Английский

Citations

0
Stress molecular signaling in interaction with cognition DOI Creative Commons

Justina F. Lugenbühl,

Eva M. G. Viho, Elisabeth B. Binder

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

3
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model DOI
Emily Z. Huie, Xin Yang,

Mengia S. Rioult-Pedotti

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Language: Английский

Citations

2
Alleviation of Antarctic krill oil on dextran sulfate sodium exposure induced chronic ulcerative colitis and depressive-like behavior DOI Creative Commons

Shu-Sen He,

Xiaoran Li, Miaomiao Zhou

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 121, P. 106418 - 106418

Published: Aug. 23, 2024

Language: Английский

Citations

1